Protein: SPIT1
Kunitz-type protease inhibitor 1 (Hepatocyte growth factor activator inhibitor type 1) (HAI-1)

Gene: SPIT1, SPINT1
Organism: Homo sapiens
Interactions: 64
UniProt ID: O43278

Gene Ontology (top 5):
GO:0001843 - neural tube closure
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

211917

HGFA
Hepatocyte growth factor activator serine protease

4

16

Small-scale

0.890

High

211910

GRAH
Granzyme H

1

15

High-throughput

0.691

High

211922

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

15

High-throughput

0.691

High

211950

KLK15
Kallikrein-15

1

15

High-throughput

0.691

High

211959

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

6

High-throughput

0.691

High

211961

ST14
Suppressor of tumorigenicity 14 protein

1

18

Small-scale

0.618

High

211908

ZN250
Zinc finger protein 250

3

6

High-throughput

0.609

High

211899

CLD11
Claudin-11

2

3

High-throughput

0.606

High

211900

UPK1B
Uroplakin-1b

2

3

High-throughput

0.606

High

211901

VAMP5
Vesicle-associated membrane protein 5

2

3

High-throughput

0.606

High

211903

TRFE
Serotransferrin

2

1

High-throughput

0.606

High

211911

MAL
Myelin and lymphocyte protein

2

1

High-throughput

0.606

High

211921

SGMR2
Sigma intracellular receptor 2

2

1

High-throughput

0.606

High

211929

TSN33
Tetraspanin-33

2

2

High-throughput

0.606

High

211936

FAM3C
Protein FAM3C

2

2

High-throughput

0.606

High

211945

TM109
Voltage-gated monoatomic cation channel TMEM109

2

1

High-throughput

0.606

High

211946

CLC7A
C-type lectin domain family 7 member A

2

15

High-throughput

0.606

High

211954

S38A7
Sodium-coupled neutral amino acid transporter 7

2

2

High-throughput

0.606

High

211957

UBQL2
Ubiquilin-2

2

8

High-throughput

0.606

High

211913

FOXK1
Forkhead box protein K1

2

3

High-throughput

0.601

High

211952

SMCO4
Single-pass membrane and coiled-coil domain-containing protein 4

2

0

High-throughput

0.580

High

211907

CBPM
Carboxypeptidase M

1

2

High-throughput

0.575

High

211930

KRA13
Keratin-associated protein 1-3

2

4

High-throughput

0.553

High

211931

AGR3
Anterior gradient protein 3

2

1

High-throughput

0.553

High

211914

FOXK2
Forkhead box protein K2

2

2

High-throughput

0.549

High

211953

UBQL4
Ubiquilin-4

1

9

High-throughput

0.541

High

211902

LY86
Lymphocyte antigen 86

1

2

High-throughput

0.536

High

211905

CFC1
Cryptic protein

1

3

High-throughput

0.536

High

211906

PRG2
Bone marrow proteoglycan

1

10

High-throughput

0.536

High

211915

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

1

High-throughput

0.536

High

211916

NRG1
Pro-neuregulin-1, membrane-bound isoform

1

3

High-throughput

0.536

High

211920

GXLT1
Glucoside xylosyltransferase 1

1

2

High-throughput

0.536

High

211925

BRID5
BRICHOS domain-containing protein 5

1

2

High-throughput

0.536

High

211926

LYPD4
Ly6/PLAUR domain-containing protein 4

1

2

High-throughput

0.536

High

211934

CLC2B
C-type lectin domain family 2 member B

1

13

High-throughput

0.536

High

211938

T106A
Transmembrane protein 106A

1

2

High-throughput

0.536

High

211939

ESPB1
Epididymal sperm-binding protein 1

1

8

High-throughput

0.536

High

211944

TM2D3
TM2 domain-containing protein 3

1

2

High-throughput

0.536

High

211949

CST11
Cystatin-11

1

6

High-throughput

0.536

High

211951

SDF2L
Stromal cell-derived factor 2-like protein 1

1

2

High-throughput

0.536

High

211958

FBX2
F-box only protein 2

1

1

High-throughput

0.536

High

211919

Q08AM2
ADAM33 protein

1

10

High-throughput

0.515

High

211909

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

0

High-throughput

0.513

High

211935

AQP3
Aquaporin-3

1

0

High-throughput

0.513

High

211904

HMGB1
High mobility group protein B1

1

7

High-throughput

0.508

High

211955

NLGN3
Neuroligin-3

1

3

Small-scale

0.508

High

191425

SIA8E
Alpha-2,8-sialyltransferase 8E

1

3

High-throughput

0.489

High

211940

TET5A
Terminal nucleotidyltransferase 5A

1

1

High-throughput

0.481

High

211948

ADA33
Disintegrin and metalloproteinase domain-containing protein 33

1

9

High-throughput

0.481

High

211912

DGKE
Diacylglycerol kinase epsilon

1

3

High-throughput

0.445

High

211918

VMAT2
Synaptic vesicular amine transporter

1

8

High-throughput

0.445

High

211927

OLFM4
Olfactomedin-4

1

4

High-throughput

0.445

High

211941

MF14A
Hippocampus abundant transcript 1 protein

1

13

High-throughput

0.445

High

211960

MAN1
Inner nuclear membrane protein Man1

1

3

High-throughput

0.445

High

211932

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.437

High

211937

ESR2
Estrogen receptor beta

1

7

High-throughput

0.437

High

211956

ZN212
Zinc finger protein 212

1

17

High-throughput

0.437

High

211924

GP107
Protein GPR107

1

0

High-throughput

0.426

High

211928

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.426

High

211923

Q5TF85
polynucleotide adenylyltransferase

1

1

High-throughput

0.417

High

211947

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

1

7

High-throughput

0.407

High

211933

TM190
Transmembrane protein 190

2

0

High-throughput

0.316

High

211942

MUS81
Structure-specific endonuclease subunit MUS81

1

0

High-throughput

0.232

Low

211943

PIGQ
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025