HitPredict

Interactor 1: NFM (P07197)
Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein)
Gene: NEFM

Interactor 2: IDE (P14735)
Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin)
Gene: IDE

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 916 Hs			1 1019
+	Hs
		539799 AINX_HUMAN (8-494): 2.98e-91: 300: 47.69		IDE_HUMAN (1-1019): 0: 1084: 100.00
+	Hs
		443298 VIME_HUMAN (8-413): 1.85e-77: 261: 44.61		IDE_HUMAN (1-1019): 0: 1084: 100.00
+	Hs
		422141 NFL_HUMAN (74-420): 2.2e-73: 253: 53.16		IDE_HUMAN (1-1019): 0: 1084: 100.00
+	Hs
		535317 GFAP_HUMAN (94-413): 1.96e-67: 233: 48.44		IDE_HUMAN (1-1019): 0: 1084: 100.00
+	Hs
		1055207 KRT81_HUMAN (1-414): 1.61e-72: 249: 27.45		PREP_HUMAN (91-965): 1.14e-133: 431: 13.57
+	Hs
		213957 KRT86_HUMAN (1-414): 1.18e-70: 243: 27.45		PREP_HUMAN (91-965): 1.14e-133: 431: 13.57
+	Hs
		213916 KRT86_HUMAN (1-414): 1.18e-70: 243: 27.45		MPPB_HUMAN (49-493): 2.22e-113: 360: 16.81
+	Hs
		213941 KRT86_HUMAN (1-414): 1.18e-70: 243: 27.45		MPPA_HUMAN (6-482): 9.37e-106: 341: 14.54
+	Hs
		264832 DESM_HUMAN (93-413): 5.49e-63: 222: 45.79		MPPB_HUMAN (49-493): 2.22e-113: 360: 16.81
+	Hs
		264804 K2C75_HUMAN (2-415): 2.25e-57: 208: 29.74		MPPB_HUMAN (49-493): 2.22e-113: 360: 16.81
+	Hs
		569074 DESM_HUMAN (93-413): 5.49e-63: 222: 45.79		MPPA_HUMAN (6-482): 9.37e-106: 341: 14.54
+	Hs
		264858 MYH9_HUMAN (52-696): 1.41e-23: 109: 11.28		MPPB_HUMAN (49-493): 2.22e-113: 360: 16.81