Protein: RETST
All-trans-retinol 13,14-reductase (EC 1.3.99.23) (All-trans-13,14-dihydroretinol saturase) (RetSat) (PPAR-alpha-regulated and starvation-induced gene protein)

Gene: RETST, RETSAT
Organism: Homo sapiens
Interactions: 126
UniProt ID: Q6NUM9

Gene Ontology (top 5):
GO:0005640 - nuclear outer membrane
GO:0005789 - endoplasmic reticulum membrane
GO:0016020 - membrane
GO:0031965 - nuclear membrane
GO:0042572 - retinol metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

212428

SPIT2
Kunitz-type protease inhibitor 2

3

1

High-throughput

0.667

High

946561

EVA1C
Protein eva-1 homolog C

3

1

High-throughput

0.667

High

1238382

SCN3B
Sodium channel regulatory subunit beta-3

3

0

High-throughput

0.634

High

944917

TMPS3
Transmembrane protease serine 3

2

1

High-throughput

0.628

High

1238366

KCNS3
Delayed-rectifier potassium channel regulatory subunit KCNS3

2

1

High-throughput

0.628

High

1238379

PCDBG
Protocadherin beta-16

2

8

High-throughput

0.628

High

1238380

I17RB
Interleukin-17 receptor B

2

1

High-throughput

0.628

High

1238387

PCDGG
Protocadherin gamma-B4

2

8

High-throughput

0.628

High

1238365

KCNKG
Potassium channel subfamily K member 16

2

1

High-throughput

0.611

High

1029430

IL9R
Interleukin-9 receptor

3

1

High-throughput

0.609

High

1238357

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

3

1

High-throughput

0.604

High

829899

PMEL
Melanocyte protein PMEL

2

0

High-throughput

0.602

High

1238343

TPRA1
Transmembrane protein adipocyte-associated 1

2

0

High-throughput

0.602

High

1238341

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

2

2

High-throughput

0.574

High

1238374

CDHR5
Cadherin-related family member 5

2

7

High-throughput

0.574

High

1238394

PCDG5
Protocadherin gamma-A5

2

8

High-throughput

0.574

High

1238395

PCDA3
Protocadherin alpha-3

2

5

High-throughput

0.574

High

178296

NPC1
NPC intracellular cholesterol transporter 1

2

1

High-throughput

0.571

High

190394

COPT1
High affinity copper uptake protein 1

2

1

High-throughput

0.549

High

1238392

PCDGH
Protocadherin gamma-B5

2

8

High-throughput

0.549

High

182592

GP182
G-protein coupled receptor 182

1

3

High-throughput

0.536

High

271599

ICOSL
ICOS ligand

1

1

High-throughput

0.536

High

537353

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.536

High

540506

LAMP1
Lysosome-associated membrane glycoprotein 1

1

1

High-throughput

0.536

High

595062

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

1

High-throughput

0.536

High

930940

HSP72
Heat shock-related 70 kDa protein 2

1

4

High-throughput

0.536

High

1085328

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

4

High-throughput

0.536

High

1238378

CP26B
Cytochrome P450 26B1

1

2

High-throughput

0.536

High

1238381

EVA1B
Protein eva-1 homolog B

1

1

High-throughput

0.536

High

1238390

PCDB3
Protocadherin beta-3

1

8

High-throughput

0.536

High

1238396

SRPRB
Signal recognition particle receptor subunit beta

1

2

High-throughput

0.536

High

376614

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

0

High-throughput

0.513

High

821679

TPOR
Thrombopoietin receptor

1

0

High-throughput

0.513

High

1126307

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

1238353

TM116
Transmembrane protein 116

1

0

High-throughput

0.513

High

1238358

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

1238362

ZDH12
Palmitoyltransferase ZDHHC12

1

0

High-throughput

0.513

High

1238363

DIESL
DGAT1/2-independent enzyme synthesizing storage lipids

1

0

High-throughput

0.513

High

1238371

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

422339

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

142354

PEX7
Peroxisomal targeting signal 2 receptor

1

8

High-throughput

0.489

High

165960

FFAR1
Free fatty acid receptor 1

1

3

High-throughput

0.489

High

349446

TSN15
Tetraspanin-15

1

4

High-throughput

0.489

High

388130

ACHA
Acetylcholine receptor subunit alpha

1

3

High-throughput

0.489

High

718412

CD6
T-cell differentiation antigen CD6

1

1

High-throughput

0.489

High

761428

HS71L
Heat shock 70 kDa protein 1-like

1

4

High-throughput

0.489

High

956907

CXCR4
C-X-C chemokine receptor type 4

1

2

High-throughput

0.489

High

1057549

ACHD
Acetylcholine receptor subunit delta

1

3

High-throughput

0.489

High

1164043

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

1

High-throughput

0.489

High

1238345

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.489

High

1238360

I17RA
Interleukin-17 receptor A

1

1

High-throughput

0.489

High

1238368

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

1

High-throughput

0.489

High

1238375

RXFP1
Relaxin receptor 1

1

3

High-throughput

0.489

High

1238383

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

1

High-throughput

0.489

High

1238389

PCDB7
Protocadherin beta-7

1

7

High-throughput

0.489

High

1238391

PCDGL
Protocadherin gamma-C4

1

7

High-throughput

0.489

High

1238393

PCDGE
Protocadherin gamma-B2

1

8

High-throughput

0.489

High

385856

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

5

High-throughput

0.479

High

845437

PE2R3
Prostaglandin E2 receptor EP3 subtype

1

0

High-throughput

0.458

High

1128748

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

1163357

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.458

High

1238373

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

211139

CTR4
Cationic amino acid transporter 4

1

5

High-throughput

0.445

High

722492

CTR1
High affinity cationic amino acid transporter 1

1

5

High-throughput

0.445

High

870247

S6A12
Sodium- and chloride-dependent betaine transporter

1

1

High-throughput

0.445

High

933523

S12A3
Solute carrier family 12 member 3

1

4

High-throughput

0.445

High

1053011

VMAT2
Synaptic vesicular amine transporter

1

3

High-throughput

0.445

High

1133780

SL9A5
Sodium/hydrogen exchanger 5

1

2

High-throughput

0.445

High

1139457

S39AE
Metal cation symporter ZIP14

1

5

High-throughput

0.445

High

1238344

ANR46
Ankyrin repeat domain-containing protein 46

1

8

High-throughput

0.445

High

1238388

S12A4
Solute carrier family 12 member 4

1

9

High-throughput

0.445

High

123398

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

1

High-throughput

0.437

High

167915

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

3

High-throughput

0.437

High

177890

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

3

High-throughput

0.437

High

908886

NEK3
Serine/threonine-protein kinase Nek3

1

5

High-throughput

0.437

High

965027

WDR5
WD repeat-containing protein 5

1

4

High-throughput

0.437

High

1042752

PTH1R
Parathyroid hormone/parathyroid hormone-related peptide receptor

1

1

High-throughput

0.437

High

1094912

TRAF3
TNF receptor-associated factor 3

1

6

Small-scale

0.437

High

1238338

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.437

High

1238355

NEK9
Serine/threonine-protein kinase Nek9

1

4

High-throughput

0.437

High

1238359

OPTN
Optineurin

1

7

High-throughput

0.437

High

1238361

TSN17
Tetraspanin-17

1

3

High-throughput

0.437

High

1238367

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

1

High-throughput

0.437

High

1238372

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.437

High

1238376

MLXPL
Carbohydrate-responsive element-binding protein

1

3

Small-scale

0.437

High

1238386

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.437

High

1097252

S13A2
Solute carrier family 13 member 2

1

0

High-throughput

0.426

High

1238337

S23A3
Solute carrier family 23 member 3

1

0

High-throughput

0.426

High

1238340

NIPA1
Magnesium transporter NIPA1

1

0

High-throughput

0.426

High

1238348

CTL3
Choline transporter-like protein 3

1

0

High-throughput

0.426

High

877680

SL9A3
Sodium/hydrogen exchanger 3

1

2

High-throughput

0.407

High

1230818

SL9A4
Sodium/hydrogen exchanger 4

1

2

High-throughput

0.407

High

1238369

S39A8
Metal cation symporter ZIP8

1

5

High-throughput

0.407

High

1238385

CCG5
Voltage-dependent calcium channel gamma-5 subunit

1

1

High-throughput

0.407

High

1238397

S12A7
Solute carrier family 12 member 7

1

9

High-throughput

0.407

High

1238352

MINY2
Ubiquitin carboxyl-terminal hydrolase MINDY-2

3

0

High-throughput

0.347

High

1212104

TRML2
Trem-like transcript 2 protein

2

0

High-throughput

0.318

High

49786

CLRN2
Clarin-2

1

0

High-throughput

0.279

Low

700791

DMB
HLA class II histocompatibility antigen, DM beta chain

1

0

High-throughput

0.279

Low

1161842

AMHR2
Anti-Muellerian hormone type-2 receptor

1

0

High-throughput

0.279

Low

1195436

NKAI1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

1

0

High-throughput

0.279

Low

1203689

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.279

Low

1204514

XKR6
XK-related protein 6

1

0

High-throughput

0.279

Low

1219673

TM268
Transmembrane protein 268

1

0

High-throughput

0.279

Low

1238350

I22R1
Interleukin-22 receptor subunit alpha-1

1

0

High-throughput

0.279

Low

1238354

TLC3A
TLC domain-containing protein 3A

1

0

High-throughput

0.279

Low

1238364

TECTB
Beta-tectorin

1

0

High-throughput

0.279

Low

1238377

TMM9B
Transmembrane protein 9B

1

0

High-throughput

0.279

Low

1238384

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

293854

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

675059

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.249

Low

830924

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

901312

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.249

Low

914431

EFNB2
Ephrin-B2

1

0

High-throughput

0.249

Low

1144276

STK38
Serine/threonine-protein kinase 38

1

0

High-throughput

0.249

Low

1238342

PAQR2
Adiponectin receptor protein 2

1

0

Small-scale

0.249

Low

1238346

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.249

Low

1238349

IQCF1
IQ domain-containing protein F1

1

0

High-throughput

0.249

Low

1238351

MLKL
Mixed lineage kinase domain-like protein

1

0

High-throughput

0.249

Low

1238356

MCLN3
Mucolipin-3

1

0

High-throughput

0.249

Low

1238370

TOLIP
Toll-interacting protein

1

0

High-throughput

0.249

Low

65411

MFS2B
Sphingosine-1-phosphate transporter MFSD2B

1

0

High-throughput

0.232

Low

166324

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

0

High-throughput

0.232

Low

303241

S22A5
Organic cation/carnitine transporter 2

1

0

High-throughput

0.232

Low

1238339

NCKX5
Sodium/potassium/calcium exchanger 5

1

0

High-throughput

0.232

Low

1238347

S15A3
Solute carrier family 15 member 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025