Protein: SPIT2
Kunitz-type protease inhibitor 2 (Hepatocyte growth factor activator inhibitor type 2) (HAI-2) (Placental bikunin)

Gene: SPIT2, SPINT2
Organism: Homo sapiens
Interactions: 165
UniProt ID: O43291

Gene Ontology (top 5):
GO:0001843 - neural tube closure
GO:0004866 - endopeptidase inhibitor activity
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005576 - extracellular region
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

212392

HGFA
Hepatocyte growth factor activator serine protease

3

15

High-throughput

0.855

High

212408

PRSS8
Prostasin

1

12

High-throughput

0.691

High

212499

KLK11
Kallikrein-11

1

13

High-throughput

0.691

High

212513

ST14
Suppressor of tumorigenicity 14 protein

1

15

High-throughput

0.691

High

212425

ASPH2
Aspartate beta-hydroxylase domain-containing protein 2

4

1

High-throughput

0.691

High

212433

UBR3
E3 ubiquitin-protein ligase UBR3

4

1

High-throughput

0.691

High

212439

FRMD5
FERM domain-containing protein 5

4

7

High-throughput

0.691

High

212456

TBC15
TBC1 domain family member 15

4

7

High-throughput

0.691

High

212381

AT12A
Potassium-transporting ATPase alpha chain 2

3

4

High-throughput

0.667

High

212385

CNTP1
Contactin-associated protein 1

3

4

High-throughput

0.667

High

212387

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

3

1

High-throughput

0.667

High

212388

AT8B2
Phospholipid-transporting ATPase ID

3

1

High-throughput

0.667

High

212396

S39A6
Zinc transporter ZIP6

3

9

High-throughput

0.667

High

212399

CKAP5
Cytoskeleton-associated protein 5

3

1

High-throughput

0.667

High

212404

KIF14
Kinesin-like protein KIF14

3

8

High-throughput

0.667

High

212413

FND3B
Fibronectin type III domain-containing protein 3B

3

7

High-throughput

0.667

High

212423

TBC9B
TBC1 domain family member 9B

3

5

High-throughput

0.667

High

212428

RETST
All-trans-retinol 13,14-reductase

3

1

High-throughput

0.667

High

212438

LRP10
Low-density lipoprotein receptor-related protein 10

3

18

High-throughput

0.667

High

212443

VRK2
Serine/threonine-protein kinase VRK2

3

9

High-throughput

0.667

High

212444

ZDH13
Palmitoyltransferase ZDHHC13

3

4

High-throughput

0.667

High

212452

MSPD2
Motile sperm domain-containing protein 2

3

3

High-throughput

0.667

High

212455

GOGA5
Golgin subfamily A member 5

3

3

High-throughput

0.667

High

212458

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

3

7

High-throughput

0.667

High

212463

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

3

3

High-throughput

0.667

High

212465

GTPB3
5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial

3

4

High-throughput

0.667

High

212473

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

3

9

High-throughput

0.667

High

212495

ZDH18
Palmitoyltransferase ZDHHC18

3

1

High-throughput

0.667

High

212500

EGFL7
Epidermal growth factor-like protein 7

3

5

High-throughput

0.667

High

212503

S39AA
Zinc transporter ZIP10

3

9

High-throughput

0.667

High

212508

FND3A
Fibronectin type-III domain-containing protein 3A

3

9

High-throughput

0.667

High

212509

MAN1
Inner nuclear membrane protein Man1

3

3

High-throughput

0.667

High

212510

DHRS7
Dehydrogenase/reductase SDR family member 7

3

2

High-throughput

0.667

High

212512

LRP12
Low-density lipoprotein receptor-related protein 12

3

17

High-throughput

0.667

High

212411

CP51A
Lanosterol 14-alpha demethylase

4

0

High-throughput

0.661

High

212451

ZNT7
Zinc transporter 7

3

3

High-throughput

0.650

High

212367

A4
Amyloid-beta precursor protein

1

17

High-throughput

0.647

High

72647

UPK3L
Uroplakin-3b-like protein 1

3

0

High-throughput

0.638

High

212363

BAG3
BAG family molecular chaperone regulator 3

3

0

High-throughput

0.638

High

212386

EREP3
Protein ENTREP3

3

0

High-throughput

0.638

High

212418

S27A3
Long-chain fatty acid transport protein 3

3

0

High-throughput

0.638

High

212424

IPIL1
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1

3

0

High-throughput

0.638

High

212442

LSR
Lipolysis-stimulated lipoprotein receptor

3

0

High-throughput

0.638

High

212449

DGLB
Diacylglycerol lipase-beta

3

0

High-throughput

0.638

High

212460

S35F5
Solute carrier family 35 member F5

3

0

High-throughput

0.638

High

212478

GCP2
Gamma-tubulin complex component 2

3

0

High-throughput

0.638

High

212504

VANG2
Vang-like protein 2

3

0

High-throughput

0.638

High

212468

SREC2
Scavenger receptor class F member 2

2

5

High-throughput

0.628

High

188733

TMPS2
Transmembrane protease serine 2

1

17

High-throughput

0.618

High

212378

ACV1B
Activin receptor type-1B

2

3

High-throughput

0.611

High

212445

MA7D3
MAP7 domain-containing protein 3

2

4

High-throughput

0.611

High

212457

P4K2B
Phosphatidylinositol 4-kinase type 2-beta

2

1

High-throughput

0.611

High

212494

SAC1
Phosphatidylinositol-3-phosphatase SAC1

2

1

High-throughput

0.611

High

212407

ELF2
ETS-related transcription factor Elf-2

3

12

High-throughput

0.609

High

212414

TIGD5
Tigger transposable element-derived protein 5

3

5

High-throughput

0.609

High

212430

MZT2B
Mitotic-spindle organizing protein 2B

3

1

High-throughput

0.609

High

212431

NFRKB
Nuclear factor related to kappa-B-binding protein

3

1

High-throughput

0.609

High

212469

P121A
Nuclear envelope pore membrane protein POM 121

3

5

High-throughput

0.609

High

212482

PRR14
Proline-rich protein 14

3

1

High-throughput

0.609

High

212493

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

3

1

High-throughput

0.609

High

212496

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

3

1

High-throughput

0.609

High

212518

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

3

1

High-throughput

0.609

High

212415

KLH22
Kelch-like protein 22

2

6

High-throughput

0.601

High

212507

DJC16
DnaJ homolog subfamily C member 16

3

11

High-throughput

0.593

High

212517

TX264
Testis-expressed protein 264

2

0

High-throughput

0.585

High

212361

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.575

High

212398

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

3

High-throughput

0.575

High

212516

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

2

3

High-throughput

0.571

High

212490

ZN696
Zinc finger protein 696

2

11

High-throughput

0.558

High

212492

CHD8
Chromodomain-helicase-DNA-binding protein 8

2

1

High-throughput

0.558

High

212511

TBL2
Transducin beta-like protein 2

2

3

High-throughput

0.558

High

212359

RNF13
E3 ubiquitin-protein ligase RNF13

1

4

High-throughput

0.536

High

212395

ILK
Scaffold protein ILK

1

1

High-throughput

0.536

High

212434

SND1
Staphylococcal nuclease domain-containing protein 1

1

2

High-throughput

0.536

High

212477

S39A3
Zinc transporter ZIP3

1

9

High-throughput

0.536

High

212372

IFM1
Interferon-induced transmembrane protein 1

1

3

High-throughput

0.515

High

212377

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.515

High

212462

CLC4D
C-type lectin domain family 4 member D

1

10

High-throughput

0.515

High

212505

CLC4E
C-type lectin domain family 4 member E

1

9

High-throughput

0.515

High

212373

CY24A
Cytochrome b-245 light chain

1

0

High-throughput

0.513

High

212421

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

0

High-throughput

0.513

High

212375

ITIH2
Inter-alpha-trypsin inhibitor heavy chain H2

1

4

Small-scale

0.501

High

76080

B4DET5
cDNA FLJ59484, highly similar to Nuclear envelope pore membrane protein POM 121

1

4

High-throughput

0.489

High

212437

MON2
Protein MON2 homolog

1

2

High-throughput

0.489

High

212447

AR6P6
ADP-ribosylation factor-like protein 6-interacting protein 6

1

1

High-throughput

0.489

High

212501

GPN3
GPN-loop GTPase 3

1

1

High-throughput

0.489

High

212476

MXRA8
Matrix remodeling-associated protein 8

1

0

High-throughput

0.481

High

212370

CATL1
Procathepsin L

1

1

High-throughput

0.479

High

212371

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

11

High-throughput

0.479

High

212374

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

1

High-throughput

0.479

High

212376

TBG1
Tubulin gamma-1 chain

1

5

High-throughput

0.479

High

212383

SC61B
Protein transport protein Sec61 subunit beta

1

2

High-throughput

0.479

High

212389

IFM3
Interferon-induced transmembrane protein 3

1

3

High-throughput

0.479

High

212390

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

1

High-throughput

0.479

High

212393

SRBP2
Sterol regulatory element-binding protein 2

1

5

High-throughput

0.479

High

212397

CUL3
Cullin-3

1

7

High-throughput

0.479

High

212400

DIP2A
Disco-interacting protein 2 homolog A

1

2

High-throughput

0.479

High

212402

CUL7
Cullin-7

1

1

High-throughput

0.479

High

212406

RHOH
Rho-related GTP-binding protein RhoH

1

2

High-throughput

0.479

High

212409

CAH9
Carbonic anhydrase 9

1

2

High-throughput

0.479

High

212417

WDR44
WD repeat-containing protein 44

1

3

High-throughput

0.479

High

212432

LMBRL
Protein LMBR1L

1

2

High-throughput

0.479

High

212435

RHOU
Rho-related GTP-binding protein RhoU

1

7

High-throughput

0.479

High

212485

OSBL8
Oxysterol-binding protein-related protein 8

1

2

High-throughput

0.479

High

212489

RHOJ
Rho-related GTP-binding protein RhoJ

1

2

High-throughput

0.479

High

212498

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

1

1

High-throughput

0.479

High

212502

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

1

Small-scale

0.479

High

212514

ALG5
Dolichyl-phosphate beta-glucosyltransferase

1

1

High-throughput

0.479

High

212362

SMC2
Structural maintenance of chromosomes protein 2

1

0

High-throughput

0.458

High

212379

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.458

High

212380

TSC2
Tuberin

1

0

High-throughput

0.458

High

212382

DPOE2
DNA polymerase epsilon subunit 2

1

0

High-throughput

0.458

High

212384

RS7
Small ribosomal subunit protein eS7

1

0

High-throughput

0.458

High

212429

TM214
Transmembrane protein 214

1

0

High-throughput

0.458

High

212475

ABCA3
Phospholipid-transporting ATPase ABCA3

1

0

High-throughput

0.458

High

212479

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.458

High

212410

MEP1B
Meprin A subunit beta

1

5

Small-scale

0.457

High

212360

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

2

High-throughput

0.445

High

212364

B3AT
Band 3 anion transport protein

1

1

High-throughput

0.445

High

212366

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

16

High-throughput

0.445

High

212391

ATP7A
Copper-transporting ATPase 1

1

4

High-throughput

0.445

High

212401

MFS10
Major facilitator superfamily domain-containing protein 10

1

15

High-throughput

0.445

High

212436

NIPA1
Magnesium transporter NIPA1

1

2

High-throughput

0.445

High

212446

RDH10
Retinol dehydrogenase 10

1

3

High-throughput

0.445

High

212448

MFSD9
Major facilitator superfamily domain-containing protein 9

1

11

High-throughput

0.445

High

212454

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

3

High-throughput

0.445

High

212461

RUFY2
RUN and FYVE domain-containing protein 2

1

6

High-throughput

0.445

High

212474

OSMR
Oncostatin-M-specific receptor subunit beta

1

5

High-throughput

0.445

High

212486

RAB34
Ras-related protein Rab-34

1

9

High-throughput

0.445

High

212506

S35A3
UDP-N-acetylglucosamine transporter

1

1

High-throughput

0.445

High

212515

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

1

3

High-throughput

0.445

High

212365

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

1

High-throughput

0.437

High

212394

CDC20
Cell division cycle protein 20 homolog

1

4

High-throughput

0.437

High

212416

KLH26
Kelch-like protein 26

1

6

High-throughput

0.437

High

212459

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.437

High

212472

LMF1
Lipase maturation factor 1

1

1

High-throughput

0.437

High

212481

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

1

High-throughput

0.437

High

117213

SIM22
Small integral membrane protein 22

1

0

Small-scale

0.426

High

212368

RB
Retinoblastoma-associated protein

1

0

High-throughput

0.426

High

212412

TM241
UDP-N-acetylglucosamine transporter TMEM241

1

0

High-throughput

0.426

High

212422

RN213
E3 ubiquitin-protein ligase RNF213

1

0

High-throughput

0.426

High

212427

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

212450

CTL5
Choline transporter-like protein 5

1

0

High-throughput

0.426

High

212464

PMEPA
Protein TMEPAI

1

0

High-throughput

0.426

High

212483

TMM59
Transmembrane protein 59

1

0

High-throughput

0.426

High

212491

ANKH
Mineralization regulator ANKH

1

0

High-throughput

0.426

High

212405

UBE3C
Ubiquitin-protein ligase E3C

1

7

High-throughput

0.407

High

212453

MFSD8
Major facilitator superfamily domain-containing protein 8

1

10

High-throughput

0.407

High

212470

SGSM3
Small G protein signaling modulator 3

1

5

High-throughput

0.407

High

212484

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

1

8

High-throughput

0.407

High

184950

SPTC2
Serine palmitoyltransferase 2

3

0

High-throughput

0.347

High

212369

HYEP
Epoxide hydrolase 1

3

0

High-throughput

0.347

High

212403

IQCB1
IQ calmodulin-binding motif-containing protein 1

3

0

High-throughput

0.347

High

212419

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

3

0

High-throughput

0.347

High

212426

LIN54
Protein lin-54 homolog

3

0

High-throughput

0.347

High

212441

NOP9
Nucleolar protein 9

3

0

High-throughput

0.347

High

212466

NGBR
Dehydrodolichyl diphosphate synthase complex subunit NUS1

3

0

High-throughput

0.347

High

212487

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

3

0

High-throughput

0.347

High

212420

MARC1
Mitochondrial amidoxime-reducing component 1

2

0

High-throughput

0.328

High

212467

THA11
THAP domain-containing protein 11

2

0

High-throughput

0.318

High

212471

SC22A
Vesicle-trafficking protein SEC22a

2

0

High-throughput

0.318

High

212480

RCAF1
GEL complex subunit OPTI

2

0

High-throughput

0.318

High

212488

CENPH
Centromere protein H

1

0

High-throughput

0.279

Low

212440

CTU1
Cytoplasmic tRNA 2-thiolation protein 1

1

0

High-throughput

0.249

Low

212497

TM160
Transmembrane protein 160

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025