HitPredict

Interactor 1: PDIA1 (P07237)
Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55)
Gene: P4HB

Interactor 2: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.681

Property	Details
Experiments	32812023, 35063084, 24098548
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, isothermal titration calorimetry
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0003779 - actin binding GO:0005576 - extracellular region GO:0005829 - cytosol GO:0019899 - enzyme binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 508 Hs			1 758
+	Hs
		496390 PDIA3_HUMAN (2-495): 1.97e-121: 367: 31.57		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496945 PDIA2_HUMAN (380-507): 1.39e-25: 111: 26.52		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		497523 ERP44_HUMAN (363-494): 1.8e-23: 104: 17.39		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		110813 H7BZJ3_HUMAN (2-111): 6.17e-21: 90.9: 46.02		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		497046 PDIA6_HUMAN (372-462): 5.71e-09: 60.1: 36.26		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		1243836 ERP44_HUMAN (363-494): 1.8e-23: 104: 17.39		KMT2C_HUMAN (83-649): 6.28e-09: 61.8: 12.91