HitPredict

Interactor 1: PDIA1 (P07237)
Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55)
Gene: P4HB

Interactor 2: DNJC3 (Q13217)
DnaJ homolog subfamily C member 3 (Endoplasmic reticulum DNA J domain-containing protein 6) (ER-resident protein ERdj6) (ERdj6) (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor of 58 kDa) (Protein kinase inhibitor p58)
Gene: DNAJC3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	33957083
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DnaJ~Thioredoxin
Common GO terms	GO:0005576 - extracellular region GO:0005783 - endoplasmic reticulum GO:0005788 - endoplasmic reticulum lumen GO:0005829 - cytosol GO:0034975 - protein folding in endoplasmic reticulum and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 508 Hs			1 504
+	Hs
		671805 PDIA3_HUMAN (2-495): 1.97e-121: 367: 31.57		DNJC3_HUMAN (1-504): 1.15e-88: 282: 100.00
+	Dm
		870464 PDI_DROME (2-477): 3.62e-130: 389: 54.93		Q9VHA8_DROME (33-504): 1.83e-64: 219: 43.86
+	Hs
		423372 PDIA1_HUMAN (1-508): 6.42e-154: 450: 100.00		DJB12_HUMAN (381-495): 7.69e-35: 136: 36.98
+	Hs
		423379 PDIA1_HUMAN (1-508): 6.42e-154: 450: 100.00		DNJB9_HUMAN (391-503): 1.35e-35: 134: 35.77
+	Hs
		174553 PDIA1_HUMAN (1-508): 6.42e-154: 450: 100.00		OGT1_HUMAN (13-134): 3.34e-16: 84: 18.03
+	Hs
		423156 PDIA1_HUMAN (1-508): 6.42e-154: 450: 100.00		STIP1_HUMAN (24-460): 7.31e-16: 82: 10.91
+	Hs
		423380 PDIA1_HUMAN (1-508): 6.42e-154: 450: 100.00		DJB11_HUMAN (393-474): 8.51e-14: 74.7: 51.81
+	Hs
		671939 PDIA3_HUMAN (2-495): 1.97e-121: 367: 31.57		DJB12_HUMAN (381-495): 7.69e-35: 136: 36.98
+	Hs
		671947 PDIA3_HUMAN (2-495): 1.97e-121: 367: 31.57		DNJB9_HUMAN (391-503): 1.35e-35: 134: 35.77
+	Dm
		870469 PDI_DROME (2-477): 3.62e-130: 389: 54.93		Q9VPN5_DROME (18-164): 4.46e-22: 100: 17.69
+	Hs
		174647 PDIA3_HUMAN (2-495): 1.97e-121: 367: 31.57		OGT1_HUMAN (13-134): 3.34e-16: 84: 18.03
+	Hs
		671948 PDIA3_HUMAN (2-495): 1.97e-121: 367: 31.57		DJB11_HUMAN (393-474): 8.51e-14: 74.7: 51.81
+	Hs
		531816 PDIA4_HUMAN (330-505): 3.94e-23: 104: 22.22		DNJC3_HUMAN (1-504): 1.15e-88: 282: 100.00
+	Hs
		531908 PDIA4_HUMAN (330-505): 3.94e-23: 104: 22.22		TTC13_HUMAN (34-337): 1.83e-49: 183: 21.36
+	Hs
		532000 PDIA4_HUMAN (330-505): 3.94e-23: 104: 22.22		DJB12_HUMAN (381-495): 7.69e-35: 136: 36.98
+	Hs
		532010 PDIA4_HUMAN (330-505): 3.94e-23: 104: 22.22		DNJB9_HUMAN (391-503): 1.35e-35: 134: 35.77
+	Rn
		956846 DJC10_RAT (265-491): 9.68e-22: 101: 17.62		DNJB9_RAT (391-504): 2.74e-35: 132: 36.67
+	Hs
		531878 PDIA4_HUMAN (330-505): 3.94e-23: 104: 22.22		TMTC3_HUMAN (9-308): 2.55e-27: 118: 11.59
+	Hs
		532011 PDIA4_HUMAN (330-505): 3.94e-23: 104: 22.22		DJB11_HUMAN (393-474): 8.51e-14: 74.7: 51.81
+	Rn
		1115513 DJC10_RAT (265-491): 9.68e-22: 101: 17.62		DJB11_RAT (393-474): 1.1e-13: 74.3: 51.81