Protein: SENP1
Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1)

Gene: SENP1
Organism: Homo sapiens
Interactions: 139
UniProt ID: Q9P0U3

Gene Ontology (top 5):
GO:0004175 - endopeptidase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005925 - focal adhesion
GO:0010724 - regulation of definitive erythrocyte differentiation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

991444

SUMO1
Small ubiquitin-related modifier 1

9

20

Small-scale

0.978

High

854759

RAGP1
Ran GTPase-activating protein 1

8

3

Small-scale

0.970

High

964480

SUMO2
Small ubiquitin-related modifier 2

6

20

Small-scale

0.956

High

939234

SUMO3
Small ubiquitin-related modifier 3

3

20

Small-scale

0.862

High

1454037

SENP1
Sentrin-specific protease 1

1

3

Small-scale

0.724

High

386316

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

5

8

High-throughput

0.702

High

1339008

NUP43
Nucleoporin Nup43

4

10

High-throughput

0.676

High

714474

PML
Protein PML

2

7

Small-scale

0.629

High

366268

FA9
Coagulation factor IX

2

1

High-throughput

0.628

High

1101917

SKP2
S-phase kinase-associated protein 2

2

1

High-throughput

0.628

High

243167

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.618

High

425660

ISG15
Ubiquitin-like protein ISG15

1

3

High-throughput

0.618

High

423361

A4
Amyloid-beta precursor protein

2

2

High-throughput

0.602

High

1060926

LRP1
Prolow-density lipoprotein receptor-related protein 1

2

0

High-throughput

0.602

High

1454044

RUVB2
RuvB-like 2

2

2

Small-scale

0.584

High

653740

PROZ
Vitamin K-dependent protein Z

2

2

High-throughput

0.574

High

1380904

ARL11
ADP-ribosylation factor-like protein 11

2

1

High-throughput

0.574

High

1088594

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

2

Small-scale

0.573

High

1402019

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

6

Small-scale

0.561

High

1454049

MORC2
ATPase MORC2

1

2

Small-scale

0.561

High

1347584

ZN420
Zinc finger protein 420

1

0

Small-scale

0.537

High

1445865

GCM1
Chorion-specific transcription factor GCMa

1

0

Small-scale

0.537

High

210211

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

1

High-throughput

0.536

High

668735

APC
Adenomatous polyposis coli protein

1

1

High-throughput

0.536

High

890409

NU153
Nuclear pore complex protein Nup153

1

8

High-throughput

0.536

High

1134411

IMB1
Importin subunit beta-1

1

5

High-throughput

0.536

High

1292819

SKAP1
Src kinase-associated phosphoprotein 1

1

2

High-throughput

0.536

High

1324604

PIAS4
E3 SUMO-protein ligase PIAS4

1

2

High-throughput

0.536

High

1340824

COP1
E3 ubiquitin-protein ligase COP1

1

9

High-throughput

0.536

High

1454039

FBLN5
Fibulin-5

1

5

High-throughput

0.536

High

1329915

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.513

High

1452032

TRM1
tRNA

1

0

High-throughput

0.513

High

487836

PARP1
Poly [ADP-ribose] polymerase 1

1

4

Small-scale

0.501

High

541063

PIM1
Serine/threonine-protein kinase pim-1

1

1

Small-scale

0.501

High

659309

SP100
Nuclear autoantigen Sp-100

1

6

Small-scale

0.501

High

890604

RBP2
E3 SUMO-protein ligase RanBP2

1

5

Small-scale

0.501

High

985928

RL11
Large ribosomal subunit protein uL5

1

1

Small-scale

0.501

High

1295748

HIPK1
Homeodomain-interacting protein kinase 1

1

2

Small-scale

0.501

High

1371747

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

1

High-throughput

0.501

High

1401288

NACC1
Nucleus accumbens-associated protein 1

1

7

Small-scale

0.501

High

1432274

HIPK2
Homeodomain-interacting protein kinase 2

1

2

Small-scale

0.501

High

1454040

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

6

Small-scale

0.501

High

568002

PRG2
Bone marrow proteoglycan

1

1

High-throughput

0.489

High

1331614

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

1

High-throughput

0.489

High

1454038

DKK3
Dickkopf-related protein 3

1

1

High-throughput

0.489

High

1454050

COL10
Collectin-10

1

1

High-throughput

0.489

High

1454048

PIAS3
E3 SUMO-protein ligase PIAS3

1

2

Small-scale

0.481

High

957684

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

0

Small-scale

0.480

High

992659

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

Small-scale

0.480

High

129499

MEN1
Menin

1

1

High-throughput

0.479

High

174627

TRI66
Tripartite motif-containing protein 66

1

6

High-throughput

0.479

High

221813

SNAI2
Zinc finger protein SNAI2

1

3

Small-scale

0.479

High

289183

PRDM1
PR domain zinc finger protein 1

1

1

Small-scale

0.479

High

291574

NU155
Nuclear pore complex protein Nup155

1

2

High-throughput

0.479

High

343087

HERC2
E3 ubiquitin-protein ligase HERC2

1

4

High-throughput

0.479

High

376039

RASK
GTPase KRas

1

2

High-throughput

0.479

High

414749

P53
Cellular tumor antigen p53

1

5

Small-scale

0.479

High

528366

THIO
Thioredoxin

1

2

Small-scale

0.479

High

581343

RAC2
Ras-related C3 botulinum toxin substrate 2

1

10

High-throughput

0.479

High

611397

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

1

High-throughput

0.479

High

613209

EGR1
Early growth response protein 1

1

1

High-throughput

0.479

High

634674

LMNB1
Lamin-B1

1

8

High-throughput

0.479

High

696726

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

732726

ARRB2
Beta-arrestin-2

1

1

Small-scale

0.479

High

895122

EMD
Emerin

1

1

High-throughput

0.479

High

941073

HDAC4
Histone deacetylase 4

1

3

High-throughput

0.479

High

945321

NU107
Nuclear pore complex protein Nup107

1

1

High-throughput

0.479

High

953723

RAC3
Ras-related C3 botulinum toxin substrate 3

1

11

High-throughput

0.479

High

955695

CDC42
Cell division control protein 42 homolog

1

11

High-throughput

0.479

High

962578

RHOA
Transforming protein RhoA

1

13

High-throughput

0.479

High

965291

WDR5
WD repeat-containing protein 5

1

6

High-throughput

0.479

High

988778

RAC1
Ras-related C3 botulinum toxin substrate 1

1

12

High-throughput

0.479

High

1015869

RHOG
Rho-related GTP-binding protein RhoG

1

11

High-throughput

0.479

High

1110132

HDAC1
Histone deacetylase 1

1

3

Small-scale

0.479

High

1138127

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

1140963

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

1252266

SYNE3
Nesprin-3

1

1

High-throughput

0.479

High

1276892

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

1281630

SLN11
Schlafen family member 11

1

1

High-throughput

0.479

High

1368163

HDAC2
Histone deacetylase 2

1

3

Small-scale

0.479

High

1387608

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

6

High-throughput

0.479

High

1395974

DNJC1
DnaJ homolog subfamily C member 1

1

2

High-throughput

0.479

High

1401054

PHF12
PHD finger protein 12

1

3

High-throughput

0.479

High

1414487

DERL1
Derlin-1

1

1

High-throughput

0.479

High

1449656

RN146
E3 ubiquitin-protein ligase RNF146

1

2

Small-scale

0.479

High

1450941

NLE1
Notchless protein homolog 1

1

5

High-throughput

0.479

High

1454041

XPO7
Exportin-7

1

1

High-throughput

0.479

High

1454042

NUP50
Nuclear pore complex protein Nup50

1

3

High-throughput

0.479

High

347968

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

590504

GATA1
Erythroid transcription factor

1

0

Small-scale

0.458

High

1005194

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1121545

KEAP1
Kelch-like ECH-associated protein 1

1

0

Small-scale

0.458

High

1289323

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

0

High-throughput

0.458

High

1326366

NIN
Ninein

1

0

High-throughput

0.458

High

1346965

SNIP1
Smad nuclear-interacting protein 1

1

0

Small-scale

0.458

High

1385644

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1387343

OTUB2
Ubiquitin thioesterase OTUB2

1

0

Small-scale

0.458

High

1405570

TBX5
T-box transcription factor TBX5

1

0

High-throughput

0.458

High

1435389

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1454047

RBGP1
Rab GTPase-activating protein 1

1

1

Small-scale

0.457

High

538036

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.445

High

1311181

UBR2
E3 ubiquitin-protein ligase UBR2

1

1

High-throughput

0.445

High

1358872

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

1

High-throughput

0.445

High

1406753

ZNT3
Probable proton-coupled zinc antiporter SLC30A3

1

1

High-throughput

0.445

High

1454043

TRAK1
Trafficking kinesin-binding protein 1

1

1

High-throughput

0.445

High

126845

RHOD
Rho-related GTP-binding protein RhoD

1

15

High-throughput

0.437

High

847729

SSRA
Translocon-associated protein subunit alpha

1

1

High-throughput

0.437

High

898148

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

1

5

High-throughput

0.437

High

910233

RND2
Rho-related GTP-binding protein RhoN

1

14

High-throughput

0.437

High

951484

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.437

High

1382969

S2546
Mitochondrial outer membrane protein SLC25A46

1

1

High-throughput

0.437

High

1404253

SEC62
Translocation protein SEC62

1

1

High-throughput

0.437

High

1411350

LZTS2
Leucine zipper putative tumor suppressor 2

1

3

High-throughput

0.437

High

1433459

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.437

High

1433551

RHOJ
Rho-related GTP-binding protein RhoJ

1

11

High-throughput

0.437

High

1436346

TMT1A
Thiol S-methyltransferase TMT1A

1

1

High-throughput

0.437

High

1438208

RHOF
Rho-related GTP-binding protein RhoF

1

14

High-throughput

0.437

High

1448163

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.437

High

1450120

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.437

High

50041

F170A
Protein FAM170A

1

0

High-throughput

0.426

High

1361872

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

0

High-throughput

0.426

High

944089

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.407

High

1310972

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

1

High-throughput

0.407

High

1128964

I13R2
Interleukin-13 receptor subunit alpha-2

2

0

High-throughput

0.328

High

1231153

SCAR3
Scavenger receptor class A member 3

2

0

High-throughput

0.318

High

1178904

CF184
Cilia- and flagella-associated protein 184

2

0

High-throughput

0.313

High

341369

ECEL1
Endothelin-converting enzyme-like 1

1

0

High-throughput

0.279

Low

880211

PTH2R
Parathyroid hormone 2 receptor

1

0

High-throughput

0.279

Low

1235344

STYK1
Tyrosine-protein kinase STYK1

1

0

High-throughput

0.279

Low

1260499

BRNP3
BMP/retinoic acid-inducible neural-specific protein 3

1

0

High-throughput

0.279

Low

1336956

LY65B
Lymphocyte antigen 6 complex locus protein G5b

1

0

High-throughput

0.279

Low

1454046

TDRKH
Tudor and KH domain-containing protein

1

0

High-throughput

0.279

Low

902901

BLK
Tyrosine-protein kinase Blk

1

0

High-throughput

0.269

Low

941377

CAV3
Caveolin-3

1

0

Small-scale

0.261

Low

1332907

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

1155107

UT2
Urea transporter 2

1

0

High-throughput

0.232

Low

1419164

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

1

0

High-throughput

0.232

Low

1454045

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025