HitPredict

Interactor 1: PDIA1 (P07237)
Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55)
Gene: P4HB

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31046837
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0070062 - extracellular exosome
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 508 Hs			1 2527
+	Hs
		160 A0A024R8S5_HUMAN (1-508): 6.42e-154: 450: 100.00		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		671835 PDIA3_HUMAN (2-495): 1.97e-121: 367: 31.57		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Mm
		447639 PDIA1_MOUSE (15-508): 4.41e-150: 440: 94.33		LRRK2_MOUSE (1-2527): 0: 2865: 86.09
+	Hs
		1130514 ERP44_HUMAN (363-494): 1.8e-23: 104: 17.39		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		531858 PDIA4_HUMAN (330-505): 3.94e-23: 104: 22.22		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		110814 H7BZJ3_HUMAN (2-111): 6.17e-21: 90.9: 46.02		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1067725 PDIA6_HUMAN (372-462): 5.71e-09: 60.1: 36.26		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		201178 PDIA1_HUMAN (1-508): 6.42e-154: 450: 100.00		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83
+	Hs
		201235 PDIA3_HUMAN (2-495): 1.97e-121: 367: 31.57		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83
+	At
		1278004 PDI52_ARATH (367-492): 1.81e-17: 86.7: 27.91		CEPR2_ARATH (921-1445): 3.86e-88: 313: 17.38
+	Hs
		201195 PDIA4_HUMAN (330-505): 3.94e-23: 104: 22.22		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83