Protein: LYL1
Protein lyl-1 (Class A basic helix-loop-helix protein 18) (bHLHa18) (Lymphoblastic leukemia-derived sequence 1)

Gene: LYL1
Organism: Homo sapiens
Interactions: 88
UniProt ID: P12980

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001955 - blood vessel maturation
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

558951

TFE2
Transcription factor E2-alpha

1

20

Small-scale

0.740

High

558952

TAL1
T-cell acute lymphocytic leukemia protein 1

1

19

Small-scale

0.691

High

558950

ITF2
Transcription factor 4

1

20

Small-scale

0.621

High

558956

RBTN2
Rhombotin-2

1

20

Small-scale

0.621

High

558957

RBTN1
Rhombotin-1

1

20

Small-scale

0.621

High

193071

NKX28
Homeobox protein Nkx-2.8

1

13

High-throughput

0.618

High

478280

HXD4
Homeobox protein Hox-D4

1

18

High-throughput

0.618

High

558947

LYL1
Protein lyl-1

1

18

High-throughput

0.618

High

558960

HXD3
Homeobox protein Hox-D3

1

20

High-throughput

0.618

High

558963

HXD13
Homeobox protein Hox-D13

1

20

High-throughput

0.618

High

558966

ID1
DNA-binding protein inhibitor ID-1

1

20

High-throughput

0.618

High

558968

ID4
DNA-binding protein inhibitor ID-4

1

20

High-throughput

0.618

High

558976

ID3
DNA-binding protein inhibitor ID-3

1

20

High-throughput

0.618

High

559002

ATOH8
Transcription factor ATOH8

1

20

High-throughput

0.618

High

558954

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

13

Small-scale

0.573

High

559019

TRI33
E3 ubiquitin-protein ligase TRIM33

1

9

Small-scale

0.536

High

558958

IKBA
NF-kappa-B inhibitor alpha

1

7

Small-scale

0.501

High

137118

MEIS1
Homeobox protein Meis1

1

3

High-throughput

0.479

High

270228

MTG16
Protein CBFA2T3

1

15

Small-scale

0.479

High

421409

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.479

High

558953

EGR1
Early growth response protein 1

1

6

High-throughput

0.479

High

558959

CCND3
G1/S-specific cyclin-D3

1

4

High-throughput

0.479

High

558964

BRCA1
Breast cancer type 1 susceptibility protein

1

5

High-throughput

0.479

High

558972

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.479

High

558973

H4
Histone H4

1

2

High-throughput

0.479

High

558984

ZN793
Zinc finger protein 793

1

4

High-throughput

0.479

High

558993

ASCC3
Activating signal cointegrator 1 complex subunit 3

1

2

High-throughput

0.479

High

558997

MRTFA
Myocardin-related transcription factor A

1

10

High-throughput

0.479

High

558998

EME1
Structure-specific endonuclease subunit EME1

1

1

High-throughput

0.479

High

559006

KAT8
Histone acetyltransferase KAT8

1

1

High-throughput

0.479

High

559008

PLCB1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

1

2

High-throughput

0.479

High

559009

PRDM8
PR domain zinc finger protein 8

1

2

High-throughput

0.479

High

297431

PIAS1
E3 SUMO-protein ligase PIAS1

1

0

High-throughput

0.458

High

335422

SLU7
Pre-mRNA-splicing factor SLU7

1

0

High-throughput

0.458

High

558969

RFX2
DNA-binding protein RFX2

1

0

High-throughput

0.458

High

558974

RS25
Small ribosomal subunit protein eS25

1

0

High-throughput

0.458

High

558981

CENPW
Centromere protein W

1

0

High-throughput

0.458

High

558999

AKTS1
Proline-rich AKT1 substrate 1

1

0

High-throughput

0.458

High

559000

PHAR3
Phosphatase and actin regulator 3

1

0

High-throughput

0.458

High

559003

PNKP
Bifunctional polynucleotide phosphatase/kinase

1

0

High-throughput

0.458

High

559005

ZN665
Zinc finger protein 665

1

0

High-throughput

0.458

High

559017

DBR1
Lariat debranching enzyme

1

0

High-throughput

0.458

High

558987

RHOU
Rho-related GTP-binding protein RhoU

1

1

High-throughput

0.457

High

174213

ARHGA
Rho guanine nucleotide exchange factor 10

1

2

High-throughput

0.437

High

252746

AP180
Clathrin coat assembly protein AP180

1

3

High-throughput

0.437

High

253045

PLIN3
Perilipin-3

1

1

High-throughput

0.437

High

317760

KBTBB
Kelch repeat and BTB domain-containing protein 11

1

7

High-throughput

0.437

High

558949

CX7A2
Cytochrome c oxidase subunit 7A2, mitochondrial

1

1

High-throughput

0.437

High

558962

SPB6
Serpin B6

1

2

High-throughput

0.437

High

558971

GMFB
Glia maturation factor beta

1

1

High-throughput

0.437

High

558980

KI26B
Kinesin-like protein KIF26B

1

4

High-throughput

0.437

High

558983

CREL2
Protein disulfide isomerase CRELD2

1

4

High-throughput

0.437

High

558988

RASE
GTPase ERas

1

2

High-throughput

0.437

High

558994

PDC6I
Programmed cell death 6-interacting protein

1

8

High-throughput

0.437

High

559001

ALS2
Alsin

1

3

High-throughput

0.437

High

559007

TBC17
TBC1 domain family member 17

1

1

High-throughput

0.437

High

559010

MXRA5
Matrix-remodeling-associated protein 5

1

3

High-throughput

0.437

High

559015

DCDC2
Doublecortin domain-containing protein 2

1

1

High-throughput

0.437

High

166617

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

0

High-throughput

0.249

Low

226930

LIAS
Lipoyl synthase, mitochondrial

1

0

High-throughput

0.249

Low

353786

PTTG1
Securin

1

0

High-throughput

0.249

Low

558948

ADRB3
Beta-3 adrenergic receptor

1

0

High-throughput

0.249

Low

558955

TRH
Pro-thyrotropin-releasing hormone

1

0

High-throughput

0.249

Low

558961

RL9
Large ribosomal subunit protein uL6

1

0

High-throughput

0.249

Low

558965

ARL1
ADP-ribosylation factor-like protein 1

1

0

High-throughput

0.249

Low

558967

DCC
Netrin receptor DCC

1

0

High-throughput

0.249

Low

558970

EFNA5
Ephrin-A5

1

0

High-throughput

0.249

Low

558975

BTG2
Protein BTG2

1

0

High-throughput

0.249

Low

558977

DLG2
Disks large homolog 2

1

0

High-throughput

0.249

Low

558978

NTRK3
NT-3 growth factor receptor

1

0

High-throughput

0.249

Low

558979

MAON
NADP-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.249

Low

558982

ACER2
Alkaline ceramidase 2

1

0

High-throughput

0.249

Low

558985

CC149
Coiled-coil domain-containing protein 149

1

0

High-throughput

0.249

Low

558986

NKAP1
Uncharacterized protein NKAPD1

1

0

High-throughput

0.249

Low

558989

TAFA5
Chemokine-like protein TAFA-5

1

0

High-throughput

0.249

Low

558990

CATAC
Centrosomal AT-AC splicing factor

1

0

High-throughput

0.249

Low

558991

LAS2
Lung adenoma susceptibility protein 2

1

0

High-throughput

0.249

Low

558992

CA2D3
Voltage-dependent calcium channel subunit alpha-2/delta-3

1

0

High-throughput

0.249

Low

558995

PIHD2
PIH1 domain-containing protein 2

1

0

High-throughput

0.249

Low

558996

PIBF1
Progesterone-induced-blocking factor 1

1

0

High-throughput

0.249

Low

559004

CMS1
Protein CMSS1

1

0

High-throughput

0.249

Low

559011

CC50A
Cell cycle control protein 50A

1

0

High-throughput

0.249

Low

559012

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.249

Low

559013

RM27
Large ribosomal subunit protein bL27m

1

0

High-throughput

0.249

Low

559014

KAAG1
Kidney-associated antigen 1

1

0

High-throughput

0.249

Low

559016

PCS1N
ProSAAS

1

0

High-throughput

0.249

Low

559018

FBX4
F-box only protein 4

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025