HitPredict

Interactor 1: KLK3 (P07288)
Prostate-specific antigen (PSA) (EC 3.4.21.77) (Gamma-seminoprotein) (Seminin) (Kallikrein-3) (P-30 antigen) (Semenogelase)
Gene: KLK3

Interactor 2: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	26186194, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0032991 - protein-containing complex GO:0070062 - extracellular exosome
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 261 Hs			1 654
+	Hs
		420734 KLK1_HUMAN (1-260): 7.96e-116: 334: 60.54		BIP_HUMAN (19-654): 0: 914: 100.00
+	Hs
		428660 TRY1_HUMAN (4-260): 2.96e-114: 329: 40.47		BIP_HUMAN (19-654): 0: 914: 100.00
+	Hs
		428712 TRY2_HUMAN (4-260): 3.65e-108: 314: 39.69		BIP_HUMAN (19-654): 0: 914: 100.00
+	Hs
		502706 KLK5_HUMAN (8-260): 5.42e-94: 280: 40.00		BIP_HUMAN (19-654): 0: 914: 100.00
+	Hs
		504752 TMPS5_HUMAN (8-256): 1.96e-90: 276: 34.22		HSP7C_HUMAN (26-637): 0: 916: 66.02
+	Hs
		502554 TMPS5_HUMAN (8-256): 1.96e-90: 276: 34.22		BIP_HUMAN (19-654): 0: 914: 100.00
+	Hs
		871779 TMPS5_HUMAN (8-256): 1.96e-90: 276: 34.22		HSP72_HUMAN (25-636): 0: 905: 64.51
+	Hs
		501693 CMA1_HUMAN (25-260): 9.9e-40: 139: 38.12		BIP_HUMAN (19-654): 0: 914: 100.00
+	Mm
		371552 CFAD_MOUSE (24-260): 3.06e-37: 133: 35.37		BIP_MOUSE (1-654): 0: 917: 98.62
+	Mm
		371752 CFAD_MOUSE (24-260): 3.06e-37: 133: 35.37		HSP7C_MOUSE (26-637): 0: 916: 66.02