Protein: HMGN4
High mobility group nucleosome-binding domain-containing protein 4 (Non-histone chromosomal protein HMG-17-like 3) (Non-histone chromosomal protein)

Gene: HMGN4
Organism: Homo sapiens
Interactions: 101
UniProt ID: O00479

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0006325 - chromatin organization
GO:0031492 - nucleosomal DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

137408

HMGN2
Non-histone chromosomal protein HMG-17

5

1

High-throughput

0.702

High

137399

H2B1K
Histone H2B type 1-K

2

20

High-throughput

0.611

High

137410

H2B1J
Histone H2B type 1-J

2

20

High-throughput

0.611

High

137427

H4
Histone H4

2

1

High-throughput

0.611

High

137460

H2A2B
Histone H2A type 2-B

2

10

High-throughput

0.611

High

137412

PARP1
Poly [ADP-ribose] polymerase 1

2

4

Small-scale

0.595

High

137481

RHG39
Rho GTPase-activating protein 39

2

1

High-throughput

0.571

High

137423

TERF1
Telomeric repeat-binding factor 1

1

2

High-throughput

0.552

High

137446

TERF2
Telomeric repeat-binding factor 2

1

2

High-throughput

0.552

High

137489

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.549

High

137434

EWS
RNA-binding protein EWS

1

1

High-throughput

0.541

High

137398

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

1

High-throughput

0.536

High

137402

H2AY
Core histone macro-H2A.1

1

14

High-throughput

0.536

High

137403

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

1

High-throughput

0.536

High

137407

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.536

High

137413

H2AZ
Histone H2A.Z

1

12

High-throughput

0.536

High

137414

H2A1
Histone H2A type 1

1

10

High-throughput

0.536

High

137417

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.536

High

137418

XRCC5
X-ray repair cross-complementing protein 5

1

1

High-throughput

0.536

High

137437

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

2

High-throughput

0.536

High

137450

H2A2C
Histone H2A type 2-C

1

10

High-throughput

0.536

High

137459

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

4

High-throughput

0.536

High

137471

RSF1
Remodeling and spacing factor 1

1

2

High-throughput

0.536

High

137490

H2AW
Core histone macro-H2A.2

1

14

High-throughput

0.536

High

137492

PARP2
Poly [ADP-ribose] polymerase 2

1

3

High-throughput

0.536

High

137400

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

0

High-throughput

0.513

High

137405

ATE1
Arginyl-tRNA--protein transferase 1

1

0

High-throughput

0.513

High

137411

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

0

High-throughput

0.513

High

137428

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.513

High

137433

XPC
DNA repair protein complementing XP-C cells

1

0

High-throughput

0.513

High

137435

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.513

High

137440

NOG2
Nucleolar GTP-binding protein 2

1

0

High-throughput

0.513

High

137452

GLYR1
Cytokine-like nuclear factor N-PAC

1

0

High-throughput

0.513

High

137455

RSBN1
Lysine-specific demethylase 9

1

0

High-throughput

0.513

High

137456

CC137
Coiled-coil domain-containing protein 137

1

0

High-throughput

0.513

High

137458

DHX30
ATP-dependent RNA helicase DHX30

1

0

High-throughput

0.513

High

137465

LEMD2
LEM domain-containing protein 2

1

0

High-throughput

0.513

High

137466

NOC3L
Nucleolar complex protein 3 homolog

1

0

High-throughput

0.513

High

137480

GTPB4
GTP-binding protein 4

1

0

High-throughput

0.513

High

137484

DDX31
ATP-dependent DNA helicase DDX31

1

0

High-throughput

0.513

High

137486

SSF1
Suppressor of SWI4 1 homolog

1

0

High-throughput

0.513

High

137494

SP16H
FACT complex subunit SPT16

1

0

High-throughput

0.513

High

137488

HPF1
Histone PARylation factor 1

1

1

Small-scale

0.501

High

137409

NPM
Nucleophosmin

1

0

High-throughput

0.493

High

137406

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.489

High

137464

KLH36
Kelch-like protein 36

1

1

High-throughput

0.489

High

137483

RPF2
Ribosome production factor 2 homolog

1

1

High-throughput

0.489

High

137396

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

137401

BRD4
Bromodomain-containing protein 4

1

5

High-throughput

0.479

High

137416

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

137419

H2B1O
Histone H2B type 1-O

1

20

High-throughput

0.479

High

137420

BRD2
Bromodomain-containing protein 2

1

7

High-throughput

0.479

High

137421

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.479

High

137425

H2BFS
Histone H2B type F-S

1

20

High-throughput

0.479

High

137426

H2B1D
Histone H2B type 1-D

1

20

High-throughput

0.479

High

137430

H31
Histone H3.1

1

7

High-throughput

0.479

High

137431

H33
Histone H3.3

1

7

High-throughput

0.479

High

137443

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

137444

BRD3
Bromodomain-containing protein 3

1

6

High-throughput

0.479

High

137447

HMGN3
High mobility group nucleosome-binding domain-containing protein 3

1

1

High-throughput

0.479

High

137448

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

137451

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.479

High

137453

H2B2F
Histone H2B type 2-F

1

20

High-throughput

0.479

High

137461

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

137463

H2B3B
Histone H2B type 3-B

1

20

High-throughput

0.479

High

137467

KAT6A
Histone acetyltransferase KAT6A

1

1

High-throughput

0.479

High

137468

H2B1H
Histone H2B type 1-H

1

20

High-throughput

0.479

High

137469

H2B1A
Histone H2B type 1-A

1

20

High-throughput

0.479

High

137474

H2B1N
Histone H2B type 1-N

1

20

High-throughput

0.479

High

137475

H2A1J
Histone H2A type 1-J

1

10

High-throughput

0.479

High

137476

H2B1M
Histone H2B type 1-M

1

20

High-throughput

0.479

High

137477

H2B1L
Histone H2B type 1-L

1

20

High-throughput

0.479

High

137478

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

137491

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

137432

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

High-throughput

0.458

High

137438

CUL4B
Cullin-4B

1

0

High-throughput

0.458

High

137439

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.458

High

137449

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

137472

TBX5
T-box transcription factor TBX5

1

0

High-throughput

0.458

High

137415

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

137454

H37
Histone H3-7

1

7

High-throughput

0.445

High

65462

PCARE
Photoreceptor cilium actin regulator

1

2

High-throughput

0.437

High

137424

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

1

High-throughput

0.437

High

137457

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

137422

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.408

High

137473

SMO
Protein smoothened

1

0

High-throughput

0.282

High

137395

RRP8
Ribosomal RNA-processing protein 8

1

0

High-throughput

0.279

Low

137404

SURF6
Surfeit locus protein 6

1

0

High-throughput

0.279

Low

137429

RL8
Large ribosomal subunit protein uL2

1

0

High-throughput

0.279

Low

137436

SRSF5
Serine/arginine-rich splicing factor 5

1

0

High-throughput

0.279

Low

137441

BOP1
Ribosome biogenesis protein BOP1

1

0

High-throughput

0.279

Low

137442

BMS1
Ribosome biogenesis protein BMS1 homolog

1

0

High-throughput

0.279

Low

137445

PUM3
Pumilio homolog 3

1

0

High-throughput

0.279

Low

137462

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

0

High-throughput

0.279

Low

137470

DDX27
Probable ATP-dependent RNA helicase DDX27

1

0

High-throughput

0.279

Low

137479

MAK16
Protein MAK16 homolog

1

0

High-throughput

0.279

Low

137482

DDX24
ATP-dependent RNA helicase DDX24

1

0

High-throughput

0.279

Low

137485

RPF1
Ribosome production factor 1

1

0

High-throughput

0.279

Low

137487

PK1IP
p21-activated protein kinase-interacting protein 1

1

0

High-throughput

0.279

Low

137493

RBM19
Probable RNA-binding protein 19

1

0

High-throughput

0.279

Low

137397

LIAS
Lipoyl synthase, mitochondrial

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025