HitPredict

Interactor 1: CRGC (P07315)
Gamma-crystallin C (Gamma-C-crystallin) (Gamma-crystallin 2-1) (Gamma-crystallin 3)
Gene: CRYGC

Interactor 2: CRBB2 (P43320)
Beta-crystallin B2 (Beta-B2 crystallin) (Beta-crystallin Bp)
Gene: CRYBB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.830

Property	Details
Experiments	11700327, 12601044
Identification Methods	two hybrid, affinity chromatography technology, coimmunoprecipitation, experimental interaction detection
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Crystall~Crystall
Common GO terms	GO:0002088 - lens development in camera-type eye GO:0005212 - structural constituent of eye lens GO:0007601 - visual perception
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 174 Hs			1 205
+	Hs
		409340 CRBA1_HUMAN (3-172): 6.68e-71: 215: 34.24		CRBB2_HUMAN (1-205): 1.16e-108: 311: 100.00
+	Hs
		795391 CRBA4_HUMAN (3-172): 2.14e-68: 207: 34.78		CRBB2_HUMAN (1-205): 1.16e-108: 311: 100.00
+	Hs
		409337 CRBA1_HUMAN (3-172): 6.68e-71: 215: 34.24		CRBA1_HUMAN (10-192): 1.9e-79: 237: 45.36
+	Hs
		863882 CRBA4_HUMAN (3-172): 2.14e-68: 207: 34.78		CRBA4_HUMAN (6-192): 4.81e-75: 225: 39.59
+	Hs
		795389 CRBB2_HUMAN (3-97): 4.88e-19: 81.8: 30.61		CRBB2_HUMAN (1-205): 1.16e-108: 311: 100.00
+	Hs
		426902 CRGC_HUMAN (1-174): 1e-95: 276: 100.00		CRGC_HUMAN (12-100): 1.5e-17: 78.1: 28.89
+	Hs
		426904 CRGC_HUMAN (1-174): 1e-95: 276: 100.00		CRGD_HUMAN (108-197): 5.5e-16: 74.2: 37.78
+	Hs
		426903 CRGC_HUMAN (1-174): 1e-95: 276: 100.00		CRGB_HUMAN (12-100): 6.57e-16: 73.8: 26.67
+	Hs
		426911 CRGD_HUMAN (1-173): 1.65e-88: 258: 71.68		CRGD_HUMAN (108-197): 5.5e-16: 74.2: 37.78
+	Hs
		409341 CRBA1_HUMAN (3-172): 6.68e-71: 215: 34.24		CRBB1_HUMAN (93-205): 1.2e-23: 96.2: 24.14
+	Hs
		863883 CRBA4_HUMAN (3-172): 2.14e-68: 207: 34.78		CRBB1_HUMAN (93-205): 1.2e-23: 96.2: 24.14
+	Hs
		795390 CRBB2_HUMAN (3-97): 4.88e-19: 81.8: 30.61		CRBA2_HUMAN (19-191): 3.55e-70: 213: 38.59
+	Hs
		863856 CRBB1_HUMAN (3-88): 1.59e-18: 81.4: 28.09		CRBA2_HUMAN (19-191): 3.55e-70: 213: 38.59
+	Hs
		409338 CRBA1_HUMAN (3-172): 6.68e-71: 215: 34.24		CRBB3_HUMAN (104-201): 2.51e-16: 75.7: 33.66