Protein: ANM8
Protein arginine N-methyltransferase 8 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4)

Gene: ANM8, PRMT8
Organism: Homo sapiens
Interactions: 91
UniProt ID: Q9NR22

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0006338 - chromatin remodeling
GO:0006355 - regulation of DNA-templated transcription
GO:0006479 - protein methylation
GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1407898

ANM1
Protein arginine N-methyltransferase 1

11

16

Small-scale

0.980

High

1447755

ANM8
Protein arginine N-methyltransferase 8

9

15

Small-scale

0.976

High

1033254

EWS
RNA-binding protein EWS

5

11

Small-scale

0.722

High

250854

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

10

9

High-throughput

0.693

High

1447764

CHTOP
Chromatin target of PRMT1 protein

4

3

High-throughput

0.691

High

475016

VIME
Vimentin

3

9

High-throughput

0.667

High

1447760

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

3

3

High-throughput

0.667

High

1027783

HNRPU
Heterogeneous nuclear ribonucleoprotein U

5

13

Small-scale

0.650

High

938137

ANM2
Protein arginine N-methyltransferase 2

1

17

Small-scale

0.647

High

1293422

CARM1
Histone-arginine methyltransferase CARM1

1

16

Small-scale

0.647

High

485443

ROA1
Heterogeneous nuclear ribonucleoprotein A1

4

19

High-throughput

0.633

High

1217805

ANGE2
Protein angel homolog 2

4

2

High-throughput

0.633

High

1168902

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

4

13

High-throughput

0.630

High

1336307

LS14A
Protein LSM14 homolog A

4

8

High-throughput

0.630

High

1405501

SCAFB
Protein SCAF11

4

3

High-throughput

0.630

High

1447759

BCLF1
Bcl-2-associated transcription factor 1

4

4

High-throughput

0.630

High

1447763

TR150
Thyroid hormone receptor-associated protein 3

4

4

High-throughput

0.630

High

214955

HNRPR
Heterogeneous nuclear ribonucleoprotein R

3

9

High-throughput

0.609

High

965905

HNRPK
Heterogeneous nuclear ribonucleoprotein K

3

14

Small-scale

0.609

High

1062666

DHX9
ATP-dependent RNA helicase A

3

7

High-throughput

0.609

High

1157259

AINX
Alpha-internexin

3

9

High-throughput

0.609

High

1290166

THOC4
THO complex subunit 4

3

11

High-throughput

0.609

High

1447762

FBW1B
F-box/WD repeat-containing protein 11

3

5

High-throughput

0.609

High

1386118

LRC45
Leucine-rich repeat-containing protein 45

2

1

High-throughput

0.601

High

331526

SPDEF
SAM pointed domain-containing Ets transcription factor

2

1

High-throughput

0.574

High

1238055

TIGD7
Tigger transposable element-derived protein 7

2

2

High-throughput

0.574

High

1333250

ZSCA1
Zinc finger and SCAN domain-containing protein 1

2

5

High-throughput

0.574

High

909712

ROA3
Heterogeneous nuclear ribonucleoprotein A3

2

18

Small-scale

0.558

High

164651

TNPO2
Transportin-2

2

1

High-throughput

0.553

High

1334961

SERB1
SERPINE1 mRNA-binding protein 1

2

6

High-throughput

0.548

High

1368896

RBP56
TATA-binding protein-associated factor 2N

2

10

Small-scale

0.543

High

714447

PML
Protein PML

1

8

High-throughput

0.536

High

1227522

A16L1
Autophagy-related protein 16-1

2

8

Small-scale

0.521

High

1416644

SUCR1
Succinate receptor 1

1

2

High-throughput

0.515

High

822876

VHL
von Hippel-Lindau disease tumor suppressor

1

3

High-throughput

0.508

High

440746

FYN
Tyrosine-protein kinase Fyn

1

2

Small-scale

0.501

High

699868

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

6

Small-scale

0.501

High

289031

ERAL1
GTPase Era, mitochondrial

1

3

High-throughput

0.489

High

1015316

ERH
Enhancer of rudimentary homolog

1

1

High-throughput

0.489

High

1023292

RBM3
RNA-binding protein 3

1

15

High-throughput

0.489

High

1120002

CIRBP
Cold-inducible RNA-binding protein

1

15

High-throughput

0.489

High

1417851

RNF26
E3 ubiquitin-protein ligase RNF26

1

2

High-throughput

0.489

High

619114

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

0

Small-scale

0.480

High

141671

DDX3X
ATP-dependent RNA helicase DDX3X

1

6

Small-scale

0.479

High

214526

RASL2
Ras GTPase-activating protein 4

1

1

Small-scale

0.479

High

409095

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

2

High-throughput

0.479

High

725662

CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial

1

2

Small-scale

0.479

High

775329

FUS
RNA-binding protein FUS

1

14

Small-scale

0.479

High

861303

MAP1B
Microtubule-associated protein 1B

1

4

High-throughput

0.479

High

953127

ACTB
Actin, cytoplasmic 1

1

3

Small-scale

0.479

High

996354

EF1A1
Elongation factor 1-alpha 1

1

1

Small-scale

0.479

High

1198089

FA98B
Protein FAM98B

1

2

High-throughput

0.479

High

1433982

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.479

High

851050

AFAM
Afamin

1

1

High-throughput

0.470

High

895661

SERPH
Serpin H1

1

1

High-throughput

0.470

High

1102265

ATM
Serine-protein kinase ATM

1

4

High-throughput

0.470

High

1334261

ATAD1
Outer mitochondrial transmembrane helix translocase

1

7

High-throughput

0.470

High

800117

COIL
Coilin

1

1

High-throughput

0.464

High

1060637

PPARA
Peroxisome proliferator-activated receptor alpha

1

20

High-throughput

0.464

High

1215371

DCAF8
DDB1- and CUL4-associated factor 8

1

9

High-throughput

0.464

High

1215517

CE162
Centrosomal protein of 162 kDa

1

7

High-throughput

0.464

High

1447756

GPT2L
G patch domain-containing protein 2-like

1

1

High-throughput

0.464

High

1447765

ZN451
E3 SUMO-protein ligase ZNF451

1

2

High-throughput

0.464

High

1437801

GRPE1
GrpE protein homolog 1, mitochondrial

1

0

Small-scale

0.458

High

644083

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

8

Small-scale

0.457

High

980391

H4
Histone H4

1

8

Small-scale

0.457

High

256998

H2B1K
Histone H2B type 1-K

1

9

High-throughput

0.437

High

451452

NFM
Neurofilament medium polypeptide

1

11

High-throughput

0.437

High

457727

TBB5
Tubulin beta chain

1

3

Small-scale

0.437

High

547701

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

4

Small-scale

0.437

High

729131

HNRH3
Heterogeneous nuclear ribonucleoprotein H3

1

15

Small-scale

0.437

High

801546

HSPA9
Stress-70 protein, mitochondrial

1

6

Small-scale

0.437

High

946890

H2B1D
Histone H2B type 1-D

1

9

High-throughput

0.437

High

981123

H2B1C
Histone H2B type 1-C/E/F/G/I

1

9

High-throughput

0.437

High

996867

TBA1B
Tubulin alpha-1B chain

1

7

Small-scale

0.437

High

1360674

SYNE2
Nesprin-2

1

6

Small-scale

0.437

High

1363335

DDX1
ATP-dependent RNA helicase DDX1

1

9

Small-scale

0.437

High

1447757

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

4

High-throughput

0.437

High

1447758

TBA8
Tubulin alpha-8 chain

1

7

Small-scale

0.437

High

1447766

PRC2C
Protein PRRC2C

1

6

High-throughput

0.437

High

1316832

OFCC1
Orofacial cleft 1 candidate gene 1 protein

1

1

High-throughput

0.417

High

1032426

OTUD4
OTU domain-containing protein 4

1

3

High-throughput

0.407

High

1180205

TUSC1
Tumor suppressor candidate gene 1 protein

1

1

High-throughput

0.407

High

1404986

GA2L1
GAS2-like protein 1

1

2

High-throughput

0.407

High

1447761

GIMA2
GTPase IMAP family member 2

2

0

High-throughput

0.328

High

1420020

UBL5
Ubiquitin-like protein 5

2

0

High-throughput

0.316

High

1394561

RSRC1
Serine/Arginine-related protein 53

1

0

High-throughput

0.279

Low

1409669

CND3
Condensin complex subunit 3

1

0

High-throughput

0.279

Low

1410677

APOL2
Apolipoprotein L2

1

0

High-throughput

0.279

Low

1186808

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025