HitPredict

Interactor 1: TRY1 (P07477)
Serine protease 1 (EC 3.4.21.4) (Anionic trypsin I) (Anionic trypsin-I) (Beta-trypsin) (Cationic trypsinogen) (Pretrypsinogen I) (Trypsin I) (Trypsin-1) [Cleaved into: Alpha-trypsin chain 1; Alpha-trypsin chain 2]
Gene: PRSS1

Interactor 2: SPB8 (P50452)
Serpin B8 (Cytoplasmic antiproteinase 2) (CAP-2) (CAP2) (Peptidase inhibitor 8) (PI-8)
Gene: SERPINB8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9402754
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Serpin~Trypsin
Common GO terms	GO:0005615 - extracellular space GO:0062023 - collagen-containing extracellular matrix
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 247 Hs			1 374
+	Mm
		430527 Q9Z1R9_MOUSE (1-246): 3.05e-132: 374: 76.83		A1AT1_MOUSE (3-374): 1.07e-138: 402: 33.86
+	Hs
		714770 TRY3_HUMAN (10-247): 1.34e-123: 354: 85.29		SPB12_HUMAN (1-374): 8.9e-145: 417: 39.51
+	Hs
		589593 KLK2_HUMAN (3-246): 2e-104: 304: 42.41		SPB6_HUMAN (1-374): 9.35e-158: 449: 66.40
+	Hs
		719387 KLK13_HUMAN (3-245): 9.95e-103: 300: 40.77		SPB6_HUMAN (1-374): 9.35e-158: 449: 66.40
+	Mm
		1141519 KLK8_MOUSE (4-243): 2.67e-103: 301: 42.86		SPB6_MOUSE (1-374): 1.16e-155: 444: 65.00
+	Hs
		344097 KLK1_HUMAN (3-247): 3.42e-104: 304: 40.93		ANT3_HUMAN (3-374): 1.73e-143: 416: 37.34
+	Hs
		344274 KLK2_HUMAN (3-246): 2e-104: 304: 42.41		AACT_HUMAN (4-374): 7.5e-141: 408: 33.25
+	Hs
		344148 KLK1_HUMAN (3-247): 3.42e-104: 304: 40.93		A1AT_HUMAN (2-374): 1.43e-139: 404: 31.75
+	Hs
		344349 KLK13_HUMAN (3-245): 9.95e-103: 300: 40.77		AACT_HUMAN (4-374): 7.5e-141: 408: 33.25
+	Hs
		341268 FA9_HUMAN (12-242): 2.82e-96: 291: 40.82		ANT3_HUMAN (3-374): 1.73e-143: 416: 37.34
+	Hs
		344149 KLK3_HUMAN (3-246): 9.02e-102: 298: 40.86		A1AT_HUMAN (2-374): 1.43e-139: 404: 31.75
+	Hs
		397636 KLK2_HUMAN (3-246): 2e-104: 304: 42.41		IPSP_HUMAN (6-374): 9.52e-137: 397: 32.53
+	Hs
		371463 KLKB1_HUMAN (15-246): 4.98e-98: 300: 35.89		IPSP_HUMAN (6-374): 9.52e-137: 397: 32.53
+	Hs
		397629 KLK3_HUMAN (3-246): 9.02e-102: 298: 40.86		IPSP_HUMAN (6-374): 9.52e-137: 397: 32.53
+	Hs
		371455 FA11_HUMAN (16-245): 2.5e-95: 293: 34.96		IPSP_HUMAN (6-374): 9.52e-137: 397: 32.53
+	Hs
		421257 KLK2_HUMAN (3-246): 2e-104: 304: 42.41		GDN_HUMAN (3-374): 9.58e-130: 379: 29.82
+	Hs
		421277 KLK13_HUMAN (3-245): 9.95e-103: 300: 40.77		GDN_HUMAN (3-374): 9.58e-130: 379: 29.82
+	Hs
		198328 KLK10_HUMAN (3-246): 4.43e-54: 177: 37.35		A1AT_HUMAN (2-374): 1.43e-139: 404: 31.75
+	Hs
		198377 KLK10_HUMAN (3-246): 4.43e-54: 177: 37.35		CBG_HUMAN (4-374): 8.44e-133: 387: 32.45
+	Hs
		198373 KLK10_HUMAN (3-246): 4.43e-54: 177: 37.35		HEP2_HUMAN (8-374): 2.05e-52: 183: 31.48