HitPredict

Interactor 1: ADRB2 (P07550)
Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor)
Gene: ADRB2

Interactor 2: GNAS2 (P63092)
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Adenylate cyclase-stimulating G alpha protein)
Gene: GNAS

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.878

Property	Details
Experiments	12036966, 28388416, 15782186, 23798571
Identification Methods	affinity chromatography technology, proximity labelling technology, fluorescent resonance energy transfer
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	7tm_1~G-alpha
Common GO terms	GO:0005886 - plasma membrane GO:0007190 - activation of adenylate cyclase activity GO:0016020 - membrane GO:0071880 - adenylate cyclase-activating adrenergic receptor signaling pathway GO:0120162 - positive regulation of cold-induced thermogenesis
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 413 Hs			1 394
+	Hs
		391305 ADRB2_HUMAN (1-413): 1.07e-122: 363: 100.00		GNAI2_HUMAN (1-394): 1.99e-158: 451: 38.83
+	Hs
		429011 ADRB2_HUMAN (1-413): 1.07e-122: 363: 100.00		GNAI1_HUMAN (1-394): 5.37e-158: 450: 39.09
+	Hs
		428884 ADRB2_HUMAN (1-413): 1.07e-122: 363: 100.00		GNAI3_HUMAN (1-394): 1.06e-155: 444: 38.58
+	Hs
		428911 ADRB2_HUMAN (1-413): 1.07e-122: 363: 100.00		GNAT2_HUMAN (9-394): 4.93e-149: 427: 39.38
+	Hs
		602211 DRD5_HUMAN (50-348): 3.24e-80: 256: 34.04		GNAS2_HUMAN (1-394): 1.94e-179: 506: 100.00
+	Hs
		580402 DRD5_HUMAN (50-348): 3.24e-80: 256: 34.04		GNAZ_HUMAN (1-393): 2.98e-142: 410: 37.15
+	Hs
		450979 OPRM_HUMAN (5-381): 1.32e-67: 221: 20.57		GNAO_HUMAN (1-394): 2.43e-153: 438: 40.66
+	Hs
		391310 ADA2A_HUMAN (3-229): 5.19e-38: 144: 36.36		GNAI2_HUMAN (1-394): 1.99e-158: 451: 38.83
+	Hs
		445801 ADA2A_HUMAN (3-229): 5.19e-38: 144: 36.36		GNAO_HUMAN (1-394): 2.43e-153: 438: 40.66