Protein: SIR2
NAD-dependent histone deacetylase SIR2 (EC 2.3.1.286) (Regulatory protein SIR2) (Silent information regulator 2)

Gene: SIR2
Organism: Saccharomyces cerevisiae S288C
Interactions: 104
UniProt ID: P06700

Gene Ontology (top 5):
GO:0000183 - rDNA heterochromatin formation
GO:0000781 - chromosome, telomeric region
GO:0000792 - heterochromatin
GO:0003688 - DNA replication origin binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

444732

SIR4
Regulatory protein SIR4

30

1

Small-scale

0.993

High

444788

H3
Histone H3

5

10

Small-scale

0.915

High

444722

SIR2
NAD-dependent histone deacetylase SIR2

5

13

Small-scale

0.902

High

380914

H2B1
Histone H2B.1

3

9

Small-scale

0.817

High

444778

NET1
Nucleolar protein NET1

20

1

Small-scale

0.766

High

444723

SIR3
Regulatory protein SIR3

8

1

Small-scale

0.749

High

444789

CDC14
Tyrosine-protein phosphatase CDC14

8

6

Small-scale

0.745

High

381783

H4
Histone H4

6

5

Small-scale

0.726

High

149183

FOB1
DNA replication fork-blocking protein FOB1

7

0

Small-scale

0.706

High

444791

TOF2
Topoisomerase 1-associated factor 2

3

1

Small-scale

0.667

High

359111

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

3

3

Small-scale

0.665

High

444750

MCM10
Minichromosome maintenance protein 10

3

0

Small-scale

0.636

High

381355

H2B2
Histone H2B.2

1

9

Small-scale

0.618

High

419318

H2A1
Histone H2A.1

1

10

Small-scale

0.618

High

444800

ESC2
Protein ESC2

3

0

Small-scale

0.617

High

444737

CSK22
Casein kinase II subunit alpha'

2

11

Small-scale

0.611

High

391994

HSP82
ATP-dependent molecular chaperone HSP82

2

3

High-throughput

0.608

High

444802

ESC8
Protein ESC8

2

0

Small-scale

0.593

High

444730

RPA1
DNA-directed RNA polymerase I subunit RPA190

2

5

Small-scale

0.584

High

444739

RPA2
DNA-directed RNA polymerase I subunit RPA135

2

2

Small-scale

0.584

High

419543

H2A2
Histone H2A.2

1

10

High-throughput

0.575

High

444806

NSI1
RNA polymerase I termination factor

1

1

Small-scale

0.561

High

444743

MCM3
DNA replication licensing factor MCM3

1

12

Small-scale

0.552

High

444728

HSP72
Heat shock protein SSA2

2

13

High-throughput

0.552

High

444731

SSB1
Ribosome-associated molecular chaperone SSB1

2

14

High-throughput

0.552

High

444755

HSP7F
Heat shock protein homolog SSE1

2

20

High-throughput

0.552

High

444804

RFM1
Repression factor of MSEs protein 1

2

1

Small-scale

0.549

High

444782

SGF73
SAGA complex subunit SGF73

1

0

Small-scale

0.537

High

444736

EF3A
Elongation factor 3A

2

5

High-throughput

0.537

High

444724

ADR1
Regulatory protein ADR1

1

6

High-throughput

0.536

High

444735

CSK21
Casein kinase II subunit alpha

1

13

High-throughput

0.536

High

444796

ERB1
Ribosome biogenesis protein ERB1

1

7

High-throughput

0.536

High

444741

GAS1
1,3-beta-glucanosyltransferase GAS1

1

0

Small-scale

0.529

High

402171

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

5

High-throughput

0.515

High

444745

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

1

High-throughput

0.515

High

444798

IMB1
Importin subunit beta-1

1

7

Small-scale

0.515

High

365783

KTHY
Thymidylate kinase

1

0

High-throughput

0.513

High

444747

RIF1
Telomere length regulator protein RIF1

1

0

High-throughput

0.513

High

444768

CHK1
Serine/threonine-protein kinase CHK1

1

0

High-throughput

0.513

High

444794

VHS1
Serine/threonine-protein kinase VHS1

1

0

High-throughput

0.513

High

444786

ZDS2
Protein ZDS2

1

3

Small-scale

0.508

High

444758

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

1

0

Small-scale

0.504

High

444772

IFH1
Protein IFH1

1

7

Small-scale

0.501

High

444738

SIR1
Regulatory protein SIR1

1

0

Small-scale

0.493

High

444740

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.493

High

444770

SAK1
SNF1-activating kinase 1

1

1

High-throughput

0.489

High

444783

FMP48
Probable serine/threonine-protein kinase FMP48

1

3

High-throughput

0.489

High

444787

DNM1
Dynamin-related protein DNM1

1

2

High-throughput

0.489

High

444746

MCM5
Minichromosome maintenance protein 5

1

13

Small-scale

0.481

High

444759

MRE11
Double-strand break repair protein MRE11

1

2

Small-scale

0.481

High

444767

MCM7
DNA replication licensing factor MCM7

1

11

Small-scale

0.481

High

444780

ZDS1
Protein ZDS1

1

4

Small-scale

0.481

High

444781

MCM6
DNA replication licensing factor MCM6

1

14

Small-scale

0.481

High

415189

TOP1
DNA topoisomerase 1

1

1

Small-scale

0.479

High

444726

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

1

High-throughput

0.479

High

444742

RAD53
Serine/threonine-protein kinase RAD53

1

2

High-throughput

0.479

High

444744

HCM1
Forkhead transcription factor HCM1

1

2

Small-scale

0.479

High

444748

XPO1
Exportin-1

1

8

Small-scale

0.479

High

444752

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

1

High-throughput

0.479

High

444753

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

1

High-throughput

0.479

High

444754

SRP40
Suppressor protein SRP40

1

2

High-throughput

0.479

High

444757

GLRX4
Monothiol glutaredoxin-4

1

3

Small-scale

0.479

High

444762

URB1
Nucleolar pre-ribosomal-associated protein 1

1

1

High-throughput

0.479

High

444763

SPT10
Protein SPT10

1

1

High-throughput

0.479

High

444766

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.479

High

444777

SUM1
Suppressor of mar1-1 protein

1

1

Small-scale

0.479

High

444785

APJ1
J domain-containing protein APJ1

1

3

High-throughput

0.479

High

444790

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

2

High-throughput

0.479

High

444792

ADA2
SAGA complex subunit ADA2

1

5

Small-scale

0.479

High

444793

IMA1
Importin subunit alpha

1

7

Small-scale

0.479

High

444795

GLRX3
Monothiol glutaredoxin-3

1

2

Small-scale

0.479

High

444805

RIO1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

444808

SMC6
Structural maintenance of chromosomes protein 6

1

8

Small-scale

0.479

High

444775

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

444779

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

444799

NHEJ1
Non-homologous end-joining protein 1

1

0

Small-scale

0.458

High

444803

SGO1
Shugoshin

1

0

High-throughput

0.458

High

444784

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

1

High-throughput

0.457

High

444725

PYR1
Multifunctional protein URA2

1

9

High-throughput

0.445

High

444727

HSP71
Heat shock protein SSA1

1

13

High-throughput

0.445

High

444756

HSP79
Heat shock protein homolog SSE2

1

20

High-throughput

0.445

High

444765

SET3
SET domain-containing protein 3

1

11

High-throughput

0.445

High

444771

CAJ1
Protein CAJ1

1

5

High-throughput

0.445

High

444774

SSB2
Ribosome-associated molecular chaperone SSB2

1

14

High-throughput

0.445

High

444807

CAF1A
Chromatin assembly factor 1 subunit A

1

2

High-throughput

0.445

High

444733

RL3
Large ribosomal subunit protein uL3

1

2

High-throughput

0.437

High

444769

ATG8
Autophagy-related protein 8

1

5

Small-scale

0.437

High

444773

BEM2
GTPase-activating protein BEM2/IPL2

1

2

High-throughput

0.437

High

444797

RTN1
Reticulon-like protein 1

1

1

Small-scale

0.437

High

444751

ASF1
Histone chaperone ASF1

1

0

High-throughput

0.426

High

444809

YN12B
Transposon Ty1-NL2 Gag-Pol polyprotein

1

0

High-throughput

0.426

High

394102

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.407

High

427067

RLA0
Large ribosomal subunit protein uL10

1

3

High-throughput

0.407

High

444749

EF2
Elongation factor 2

1

2

High-throughput

0.407

High

444760

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.407

High

444761

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.407

High

444776

STU2
Protein STU2

1

2

High-throughput

0.407

High

358082

ADH1
Alcohol dehydrogenase 1

2

0

High-throughput

0.307

High

444734

BGL2
Glucan 1,3-beta-glucosidase

2

0

High-throughput

0.307

High

444764

YKC3
Uncharacterized protein YKL023W

1

0

High-throughput

0.279

Low

444729

PCKA
Phosphoenolpyruvate carboxykinase

1

0

Small-scale

0.261

Low

444801

NCS1
Calcium-binding protein NCS-1

1

0

High-throughput

0.238

Low

364865

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025