Interactor 1: SYEP (P07814)
Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)]
Gene: EPRS1

Interactor 2: SYK (Q15046)
Lysine--tRNA ligase (EC 2.7.7.-) (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS)
Gene: KARS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.85 0.60 0.716

The method score is based on:

Property Details
Experiments 28514442, 33961781, 22751010, 21220307, 22386318
Identification Methods affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0017101 - aminoacyl-tRNA synthetase multienzyme complex
GO:0042803 - protein homodimerization activity
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 1512
Hs

1 597
+ Hs
+ Sc
+ Hs
+ Sc
+ Sc
+ Sc
+ Sc
+ Sc
+ Dm
+ Sc
+ Sc
+ Hs
+ Dm
+ Sc
+ Sc
+ Sc
+ Sc
+ Cj

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Last updated: 15 Jul 2024