HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: CD11B (P21127)
Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1)
Gene: CDK11B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	15344906, 35271311, 22939624
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0003723 - RNA binding GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0042981 - regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 795
+	Hs
		432370 HS90A_HUMAN (1-732): 0: 1087: 100.00		CD11A_HUMAN (1-795): 0: 561: 96.86
+	Hs
		438628 HS90B_HUMAN (19-732): 0: 1059: 86.13		CD11A_HUMAN (1-795): 0: 561: 96.86
+	Hs
		431549 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK2_HUMAN (435-731): 1.45e-154: 454: 43.96
+	Hs
		431741 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK3_HUMAN (435-731): 8.54e-148: 436: 45.64
+	Hs
		437908 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK2_HUMAN (435-731): 1.45e-154: 454: 43.96
+	Hs
		414683 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK1_HUMAN (435-726): 7.24e-138: 411: 41.84
+	Hs
		431743 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK5_HUMAN (435-729): 1.29e-137: 410: 41.55
+	Hs
		438075 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK3_HUMAN (435-731): 8.54e-148: 436: 45.64
+	Hs
		431867 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK10_HUMAN (429-760): 3.17e-133: 401: 52.41
+	Hs
		438077 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK5_HUMAN (435-729): 1.29e-137: 410: 41.55
+	Hs
		438185 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK10_HUMAN (429-760): 3.17e-133: 401: 52.41
+	Hs
		538107 ENPL_HUMAN (14-701): 0: 898: 46.78		CDK2_HUMAN (435-731): 1.45e-154: 454: 43.96
+	Hs
		431662 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK7_HUMAN (436-760): 1.13e-72: 243: 38.69
+	Hs
		438004 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK7_HUMAN (436-760): 1.13e-72: 243: 38.69
+	Hs
		1123462 H90B3_HUMAN (19-732): 0: 728: 65.41		CD11A_HUMAN (1-795): 0: 561: 96.86
+	Ca
		793050 HSP90_CANAL (12-732): 0: 914: 60.50		CDK1_CANAL (435-723): 2.17e-81: 265: 48.63
+	Sc
		339312 HSP82_YEAST (16-732): 0: 907: 60.08		CDK1_YEAST (438-726): 1.02e-78: 257: 47.28
+	Sc
		339406 HSC82_YEAST (16-732): 0: 902: 59.39		CDK1_YEAST (438-726): 1.02e-78: 257: 47.28
+	Hs
		841224 H90B3_HUMAN (19-732): 0: 728: 65.41		CDK7_HUMAN (436-760): 1.13e-72: 243: 38.69
+	Hs
		841223 H90B4_HUMAN (30-604): 0: 571: 62.61		CDK7_HUMAN (436-760): 1.13e-72: 243: 38.69