HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: UB2R1 (P49427)
Ubiquitin-conjugating enzyme E2 R1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme R1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme R1) (Ubiquitin-conjugating enzyme E2-32 kDa complementing) (Ubiquitin-conjugating enzyme E2-CDC34) (Ubiquitin-protein ligase R1)
Gene: CDC34

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29564676
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 236
+	Hs
		437988 HS90B_HUMAN (19-732): 0: 1059: 86.13		UB2R1_HUMAN (1-236): 1.98e-95: 280: 100.00
+	Hs
		438042 HS90B_HUMAN (19-732): 0: 1059: 86.13		UB2D3_HUMAN (9-167): 3.52e-69: 210: 29.38
+	Sc
		539436 HSC82_YEAST (16-732): 0: 902: 59.39		UBC3_YEAST (7-232): 1.2e-70: 219: 34.35
+	Sc
		365722 HSP82_YEAST (16-732): 0: 907: 60.08		UBC4_YEAST (8-166): 8.82e-68: 207: 31.88
+	Sc
		543118 HSC82_YEAST (16-732): 0: 902: 59.39		UBC4_YEAST (8-166): 8.82e-68: 207: 31.88
+	Sc
		366754 HSP82_YEAST (16-732): 0: 907: 60.08		UBC7_YEAST (5-157): 3.8e-65: 201: 45.75
+	Sc
		544266 HSC82_YEAST (16-732): 0: 902: 59.39		UBC7_YEAST (5-157): 3.8e-65: 201: 45.75
+	Sc
		544084 HSC82_YEAST (16-732): 0: 902: 59.39		UBC11_YEAST (11-148): 3.83e-26: 100: 41.30