Protein: ITAM
Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b)

Gene: ITAM, ITGAM
Organism: Homo sapiens
Interactions: 69
UniProt ID: P11215

Gene Ontology (top 5):
GO:0001540 - amyloid-beta binding
GO:0001774 - microglial cell activation
GO:0001851 - complement component C3b binding
GO:0002430 - complement receptor mediated signaling pathway
GO:0002931 - response to ischemia

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

424053

ITB2
Integrin beta-2

3

20

Small-scale

0.839

High

539500

SCN3B
Sodium channel regulatory subunit beta-3

2

1

High-throughput

0.783

High

539458

PTN
Pleiotrophin

1

1

Small-scale

0.716

High

539457

SPI1
Transcription factor PU.1

5

2

Small-scale

0.706

High

210694

KLK10
Kallikrein-10

1

13

High-throughput

0.691

High

427782

ICAM1
Intercellular adhesion molecule 1

1

7

Small-scale

0.647

High

539491

JAM3
Junctional adhesion molecule C

1

4

Small-scale

0.647

High

369819

CO3
Complement C3

1

5

Small-scale

0.618

High

539459

PRTN3
Myeloblastin

1

9

Small-scale

0.618

High

539460

CEAM8
Cell adhesion molecule CEACAM8

1

9

Small-scale

0.618

High

539495

CLC4M
C-type lectin domain family 4 member M

1

6

Small-scale

0.618

High

539455

MUC1
Mucin-1

2

1

High-throughput

0.606

High

539461

KI2L3
Killer cell immunoglobulin-like receptor 2DL3

2

6

High-throughput

0.606

High

539463

CXA8
Gap junction alpha-8 protein

2

3

High-throughput

0.606

High

539490

REEP2
Receptor expression-enhancing protein 2

2

1

High-throughput

0.606

High

539464

BAP31
B-cell receptor-associated protein 31

1

1

Small-scale

0.589

High

539453

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

0

High-throughput

0.580

High

539462

KCNJ6
G protein-activated inward rectifier potassium channel 2

2

0

High-throughput

0.580

High

539467

CLRN1
Clarin-1

2

0

High-throughput

0.580

High

539472

SOAT
Sodium-dependent organic anion transporter

2

0

High-throughput

0.580

High

539474

TM52B
Transmembrane protein 52B

2

0

High-throughput

0.580

High

539479

EMC5
ER membrane protein complex subunit 5

2

0

High-throughput

0.580

High

539482

SYT2
Synaptotagmin-2

2

0

High-throughput

0.580

High

539501

DKK4
Dickkopf-related protein 4

2

0

High-throughput

0.580

High

464669

CXB1
Gap junction beta-1 protein

2

3

High-throughput

0.553

High

539473

AR13B
ADP-ribosylation factor-like protein 13B

2

8

High-throughput

0.553

High

539478

DHB13
17-beta-hydroxysteroid dehydrogenase 13

2

1

High-throughput

0.553

High

539480

KASH5
Protein KASH5

2

3

High-throughput

0.553

High

539487

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

3

High-throughput

0.553

High

539496

REEP4
Receptor expression-enhancing protein 4

2

1

High-throughput

0.553

High

539504

TMX2
Thioredoxin-related transmembrane protein 2

2

1

High-throughput

0.553

High

539492

TX101
Testis-expressed protein 101

1

4

High-throughput

0.536

High

539502

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

1

High-throughput

0.536

High

539454

VAV
Proto-oncogene vav

1

2

Small-scale

0.515

High

193389

GPR42
G-protein coupled receptor 42

1

3

High-throughput

0.515

High

539465

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

Small-scale

0.493

High

539489

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

1

High-throughput

0.489

High

539505

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

5

Small-scale

0.481

High

539469

UPAR
Urokinase plasminogen activator surface receptor

1

0

Small-scale

0.480

High

240588

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

387370

APOE
Apolipoprotein E

1

1

Small-scale

0.479

High

421389

A4
Amyloid-beta precursor protein

1

5

Small-scale

0.479

High

471528

CD14
Monocyte differentiation antigen CD14

1

1

Small-scale

0.479

High

539456

LEG3
Galectin-3

1

20

Small-scale

0.479

High

539471

BGH3
Transforming growth factor-beta-induced protein ig-h3

1

0

Small-scale

0.458

High

539481

CD177
CD177 antigen

1

4

Small-scale

0.445

High

385396

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

6

High-throughput

0.439

High

464775

SP1
Transcription factor Sp1

1

3

Small-scale

0.437

High

539468

SP3
Transcription factor Sp3

1

3

Small-scale

0.437

High

539484

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.437

High

539494

SHRPN
Sharpin

1

7

Small-scale

0.373

High

166853

MGST3
Glutathione S-transferase 3, mitochondrial

2

0

High-throughput

0.316

High

181240

PGRC2
Membrane-associated progesterone receptor component 2

2

0

High-throughput

0.316

High

350345

ABHGA
Phosphatidylserine lipase ABHD16A

2

0

High-throughput

0.316

High

539466

PIGP
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P

2

0

High-throughput

0.316

High

539470

AQP6
Aquaporin-6

2

0

High-throughput

0.316

High

539476

GORAB
RAB6-interacting golgin

2

0

High-throughput

0.316

High

539477

MRM1
rRNA methyltransferase 1, mitochondrial

2

0

High-throughput

0.316

High

539483

T229B
Transmembrane protein 229B

2

0

High-throughput

0.316

High

539488

RUSF1
RUS family member 1

2

0

High-throughput

0.316

High

539493

ELOV4
Very long chain fatty acid elongase 4

2

0

High-throughput

0.316

High

539497

CERS4
Ceramide synthase 4

2

0

High-throughput

0.316

High

539498

S35C2
Solute carrier family 35 member C2

2

0

High-throughput

0.316

High

539499

TM14B
Transmembrane protein 14B

2

0

High-throughput

0.316

High

539503

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

0

High-throughput

0.316

High

539485

RHBL4
Rhomboid-related protein 4

1

0

High-throughput

0.279

Low

539475

TMM31
Transmembrane protein 31

1

0

High-throughput

0.251

Low

539486

GPX8
Probable glutathione peroxidase 8

1

0

High-throughput

0.251

Low

238365

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025