Protein: CD14
Monocyte differentiation antigen CD14 (My23 antigen) (Myeloid cell-specific leucine-rich glycoprotein) (CD antigen CD14) [Cleaved into: Monocyte differentiation antigen CD14, urinary form; Monocyte differentiation antigen CD14, membrane-bound form]

Gene: CD14
Organism: Homo sapiens
Interactions: 59
UniProt ID: P08571

Gene Ontology (top 5):
GO:0001530 - lipopolysaccharide binding
GO:0001819 - positive regulation of cytokine production
GO:0001847 - opsonin receptor activity
GO:0001875 - lipopolysaccharide immune receptor activity
GO:0002752 - cell surface pattern recognition receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

252313

TLR2
Toll-like receptor 2

3

10

Small-scale

0.834

High

380399

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

0

High-throughput

0.656

High

471530

LBP
Lipopolysaccharide-binding protein

3

0

Small-scale

0.632

High

126283

TLR4
Toll-like receptor 4

1

10

Small-scale

0.618

High

191198

TLR3
Toll-like receptor 3

1

10

Small-scale

0.618

High

471561

TLR9
Toll-like receptor 9

1

10

Small-scale

0.618

High

471562

TLR8
Toll-like receptor 8

1

10

Small-scale

0.618

High

471564

TLR7
Toll-like receptor 7

1

10

Small-scale

0.618

High

471542

FSTL1
Follistatin-related protein 1

2

0

Small-scale

0.593

High

471571

IRAK3
Interleukin-1 receptor-associated kinase 3

1

0

High-throughput

0.589

High

390982

TRFL
Lactotransferrin

1

0

Small-scale

0.537

High

471533

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

0

High-throughput

0.518

High

471537

CXB2
Gap junction beta-2 protein

1

0

High-throughput

0.518

High

471560

ARFG3
ADP-ribosylation factor GTPase-activating protein 3

1

0

High-throughput

0.518

High

144036

MA2B1
Lysosomal alpha-mannosidase

1

0

High-throughput

0.513

High

251696

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

0

High-throughput

0.513

High

336322

SVIL
Supervillin

1

0

High-throughput

0.513

High

424575

PAI1
Plasminogen activator inhibitor 1

1

0

High-throughput

0.513

High

441405

CHLE
Cholinesterase

1

0

High-throughput

0.513

High

462829

LAMB1
Laminin subunit beta-1

1

0

High-throughput

0.513

High

471538

GALNS
N-acetylgalactosamine-6-sulfatase

1

0

High-throughput

0.513

High

471548

GT253
Inactive glycosyltransferase 25 family member 3

1

0

High-throughput

0.513

High

471549

ARID2
AT-rich interactive domain-containing protein 2

1

0

High-throughput

0.513

High

471552

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.513

High

471553

RN133
E3 ubiquitin-protein ligase RNF133

1

0

High-throughput

0.513

High

471554

AP3S1
AP-3 complex subunit sigma-1

1

0

High-throughput

0.513

High

471565

ERAP1
Endoplasmic reticulum aminopeptidase 1

1

0

High-throughput

0.513

High

471567

ICAM5
Intercellular adhesion molecule 5

1

0

High-throughput

0.513

High

471569

EXO1
Exonuclease 1

1

0

High-throughput

0.513

High

471541

NAL12
NACHT, LRR and PYD domains-containing protein 12

1

0

Small-scale

0.494

High

471528

ITAM
Integrin alpha-M

1

1

Small-scale

0.479

High

471532

ANXA7
Annexin A7

1

1

High-throughput

0.479

High

471531

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

Small-scale

0.458

High

471535

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

0

Small-scale

0.458

High

471539

PHB1
Prohibitin 1

1

0

Small-scale

0.458

High

471543

SKP2
S-phase kinase-associated protein 2

1

0

Small-scale

0.458

High

471544

DIP2A
Disco-interacting protein 2 homolog A

1

0

Small-scale

0.458

High

471546

LY6E
Lymphocyte antigen 6E

1

0

Small-scale

0.458

High

471534

TAF1
Transcription initiation factor TFIID subunit 1

1

1

High-throughput

0.437

High

471551

CD177
CD177 antigen

1

0

Small-scale

0.426

High

76390

B4DT77
Annexin

1

1

High-throughput

0.407

High

114470

H0Y9L7
TATA-box binding protein associated factor 1

1

1

High-throughput

0.407

High

471540

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

0

High-throughput

0.282

High

471556

CANB2
Calcineurin subunit B type 2

1

0

High-throughput

0.282

High

71425

P20L1
PHD finger protein 20-like protein 1

1

0

High-throughput

0.279

Low

239294

MYPT2
Protein phosphatase 1 regulatory subunit 12B

1

0

High-throughput

0.279

Low

471545

OASL
2'-5'-oligoadenylate synthase-like protein

1

0

High-throughput

0.279

Low

471547

TAF9
Transcription initiation factor TFIID subunit 9

1

0

High-throughput

0.279

Low

471550

TXD11
Thioredoxin domain-containing protein 11

1

0

High-throughput

0.279

Low

471555

PF21A
PHD finger protein 21A

1

0

High-throughput

0.279

Low

471557

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.279

Low

471558

WDCP
WD repeat and coiled-coil-containing protein

1

0

High-throughput

0.279

Low

471559

BCAS3
BCAS3 microtubule associated cell migration factor

1

0

High-throughput

0.279

Low

471563

INT7
Integrator complex subunit 7

1

0

High-throughput

0.279

Low

471566

FBX2
F-box only protein 2

1

0

High-throughput

0.279

Low

471568

HPS5
BLOC-2 complex member HPS5

1

0

High-throughput

0.279

Low

471570

RRP44
Exosome complex exonuclease RRP44

1

0

High-throughput

0.279

Low

471529

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

Small-scale

0.249

Low

471536

MZF1
Myeloid zinc finger 1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025