Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: TEBP (Q15185)
Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23)
Gene: PTGES3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 0.60 0.770

The method score is based on:

Property Details
Experiments 18172314, 16565516, 19996313, 19740745, 20048054, 16289154, 26804907, 27353360, 11812147, 20159553, 15916966, 20039095, 22315411, 20661446, 22729780, 19875381, 9817749, 21988832, 10811660, 22806877 and 14 others

more...

Identification Methods affinity chromatography technology, pull down, two hybrid, protein complementation assay, coimmunoprecipitation, tandem affinity purification, anti tag coimmunoprecipitation, luminescence based mammalian interactome mapping
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006457 - protein folding
GO:0007004 - telomere maintenance via telomerase
and 7 others

more...

Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 732
Hs

1 160
+ Mm
+ Hs
+ Hs
+ Sc
+ Sc
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024