HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: CDKL4 (Q5MAI5)
Cyclin-dependent kinase-like 4 (EC 2.7.11.22)
Gene: CDKL4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 379
+	Hs
		431549 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK2_HUMAN (1-292): 3.58e-140: 402: 37.76
+	Hs
		431741 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK3_HUMAN (1-297): 3.87e-138: 397: 39.47
+	Hs
		431807 HS90A_HUMAN (1-732): 0: 1087: 100.00		MK07_HUMAN (2-365): 5.34e-131: 396: 24.80
+	Hs
		432124 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDKL2_HUMAN (1-334): 1e-134: 395: 49.57
+	Hs
		414683 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK1_HUMAN (1-291): 4.58e-132: 381: 37.42
+	Hs
		431743 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK5_HUMAN (1-292): 1.51e-130: 377: 37.76
+	Hs
		437908 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK2_HUMAN (1-292): 3.58e-140: 402: 37.76
+	Hs
		438250 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDKL4_HUMAN (1-379): 2.28e-137: 398: 100.00
+	Mm
		513710 HS90B_MOUSE (19-732): 0: 1063: 86.98		MK07_MOUSE (2-365): 1.9e-130: 394: 25.33
+	Rn
		92848 HS90B_RAT (19-732): 0: 1063: 86.98		E9PTH2_RAT (2-365): 1.88e-130: 394: 25.33
+	Hs
		438075 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK3_HUMAN (1-297): 3.87e-138: 397: 39.47
+	Hs
		438129 HS90B_HUMAN (19-732): 0: 1059: 86.13		MK07_HUMAN (2-365): 5.34e-131: 396: 24.80
+	Hs
		438077 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK5_HUMAN (1-292): 1.51e-130: 377: 37.76
+	Mm
		513676 HS90B_MOUSE (19-732): 0: 1063: 86.98		CDKL5_MOUSE (1-288): 5.7e-86: 281: 46.74
+	Hs
		431662 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK7_HUMAN (2-288): 1.63e-62: 205: 38.87
+	Hs
		432045 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK20_HUMAN (1-286): 1.24e-59: 198: 38.41
+	Hs
		438004 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK7_HUMAN (2-288): 1.63e-62: 205: 38.87
+	Hs
		438342 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK20_HUMAN (1-286): 1.24e-59: 198: 38.41
+	Sc
		365744 HSP82_YEAST (16-732): 0: 907: 60.08		PHO85_YEAST (3-289): 2.76e-63: 206: 37.00
+	Sp
		383458 HSP90_SCHPO (15-732): 0: 914: 62.08		CDK1_SCHPO (1-290): 6.66e-60: 197: 33.99