HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: HECD3 (Q5T447)
E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3)
Gene: HECTD3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22939624
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 861
+	Hs
		438254 HS90B_HUMAN (19-732): 0: 1059: 86.13		HECD3_HUMAN (1-861): 0: 1137: 100.00
+	Hs
		125097 HS90A_HUMAN (1-732): 0: 1087: 100.00		WWP2_HUMAN (321-855): 1.45e-172: 523: 17.74
+	Hs
		432252 HS90A_HUMAN (1-732): 0: 1087: 100.00		WWP1_HUMAN (250-855): 1.18e-171: 522: 16.67
+	Hs
		432005 HS90A_HUMAN (1-732): 0: 1087: 100.00		HUWE1_HUMAN (329-854): 6.82e-152: 496: 19.78
+	Hs
		125101 HS90B_HUMAN (19-732): 0: 1059: 86.13		WWP2_HUMAN (321-855): 1.45e-172: 523: 17.74
+	Hs
		438516 HS90B_HUMAN (19-732): 0: 1059: 86.13		WWP1_HUMAN (250-855): 1.18e-171: 522: 16.67
+	Hs
		438309 HS90B_HUMAN (19-732): 0: 1059: 86.13		HUWE1_HUMAN (329-854): 6.82e-152: 496: 19.78
+	Hs
		538146 ENPL_HUMAN (14-701): 0: 898: 46.78		NEDD4_HUMAN (322-853): 5.8e-176: 545: 18.46
+	Sc
		366333 HSP82_YEAST (16-732): 0: 907: 60.08		RSP5_YEAST (371-855): 1.15e-164: 501: 18.53
+	Sc
		543785 HSC82_YEAST (16-732): 0: 902: 59.39		RSP5_YEAST (371-855): 1.15e-164: 501: 18.53
+	Hs
		538295 ENPL_HUMAN (14-701): 0: 898: 46.78		HUWE1_HUMAN (329-854): 6.82e-152: 496: 19.78
+	Sc
		366793 HSP82_YEAST (16-732): 0: 907: 60.08		TOM1_YEAST (436-849): 1.84e-118: 398: 23.61
+	Zm
		17433 A0A1D6GWE1_MAIZE (4-700): 0: 836: 46.14		A0A1D6MU59_MAIZE (425-853): 5.37e-142: 467: 21.45
+	Sc
		544310 HSC82_YEAST (16-732): 0: 902: 59.39		TOM1_YEAST (436-849): 1.84e-118: 398: 23.61
+	Hs
		438178 HS90B_HUMAN (19-732): 0: 1059: 86.13		CUL7_HUMAN (245-370): 1.55e-18: 93.6: 40.63
+	Hs
		319705 ENPL_HUMAN (14-701): 0: 898: 46.78		HERC2_HUMAN (237-372): 5.72e-44: 175: 35.77
+	Hs
		538246 ENPL_HUMAN (14-701): 0: 898: 46.78		UBE3C_HUMAN (495-845): 2.66e-20: 99: 27.64
+	Hs
		538235 ENPL_HUMAN (14-701): 0: 898: 46.78		CUL7_HUMAN (245-370): 1.55e-18: 93.6: 40.63