HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: EPAS1 (Q99814)
Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2)
Gene: EPAS1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	34931765, 15319539
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 870
+	Hs
		431903 HS90A_HUMAN (1-732): 0: 1087: 100.00		HIF1A_HUMAN (3-868): 0: 553: 42.32
+	Mm
		432431 HS90A_MOUSE (1-732): 0: 1083: 97.82		HIF1A_MOUSE (3-787): 0: 549: 43.60
+	Hs
		438217 HS90B_HUMAN (19-732): 0: 1059: 86.13		HIF1A_HUMAN (3-868): 0: 553: 42.32
+	Hs
		431737 HS90A_HUMAN (1-732): 0: 1087: 100.00		SIM1_HUMAN (16-672): 1.27e-148: 458: 24.04
+	Mm
		432429 HS90A_MOUSE (1-732): 0: 1083: 97.82		SIM1_MOUSE (16-672): 6.29e-149: 459: 24.22
+	Hs
		431844 HS90A_HUMAN (1-732): 0: 1087: 100.00		SIM2_HUMAN (16-646): 3.33e-146: 448: 24.25
+	Hs
		438165 HS90B_HUMAN (19-732): 0: 1059: 86.13		SIM2_HUMAN (16-646): 3.33e-146: 448: 24.25
+	Hs
		431556 HS90A_HUMAN (1-732): 0: 1087: 100.00		ARNT_HUMAN (2-644): 5.31e-129: 407: 19.24
+	Hs
		126097 HS90A_HUMAN (1-732): 0: 1087: 100.00		BMAL1_HUMAN (1-524): 1.58e-129: 403: 20.70
+	Hs
		432385 HS90A_HUMAN (1-732): 0: 1087: 100.00		HIF3A_HUMAN (1-690): 1.89e-126: 397: 35.42
+	Hs
		431594 HS90A_HUMAN (1-732): 0: 1087: 100.00		AHR_HUMAN (5-706): 9.13e-121: 387: 16.46
+	Mm
		432410 HS90A_MOUSE (1-732): 0: 1083: 97.82		AHR_MOUSE (5-792): 9.67e-122: 390: 16.96
+	Rn
		783943 HS90A_RAT (1-732): 0: 1085: 97.95		AHR_RAT (5-787): 2.73e-115: 373: 16.94
+	Mm
		513659 HS90B_MOUSE (19-732): 0: 1063: 86.98		AHR_MOUSE (5-792): 9.67e-122: 390: 16.96
+	Hs
		432199 HS90A_HUMAN (1-732): 0: 1087: 100.00		NPAS2_HUMAN (1-770): 5.24e-96: 321: 17.18
+	Hs
		438468 HS90B_HUMAN (19-732): 0: 1059: 86.13		NPAS1_HUMAN (1-522): 8.79e-103: 332: 23.12
+	Dm
		1096504 Q9VAY2_DROME (15-700): 0: 537: 46.13		SIMA_DROME (2-492): 3.66e-94: 326: 31.18