HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: GBRL1 (Q9H0R8)
Gamma-aminobutyric acid receptor-associated protein-like 1 (Early estrogen-regulated protein) (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1)
Gene: GABARAPL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.641

Property	Details
Experiments	22120110, 29149599, 20562859
Identification Methods	pull down, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 117
+	Hs
		431708 HS90A_HUMAN (1-732): 0: 1087: 100.00		GBRL2_HUMAN (1-116): 1.39e-57: 175: 61.21
+	Hs
		305906 HS90A_HUMAN (1-732): 0: 1087: 100.00		GBRAP_HUMAN (1-116): 2.96e-56: 171: 87.07
+	Rn
		948935 HS90A_RAT (1-732): 0: 1085: 97.95		GBRL1_RAT (1-117): 4.54e-56: 171: 100.00
+	Hs
		438039 HS90B_HUMAN (19-732): 0: 1059: 86.13		GBRL2_HUMAN (1-116): 1.39e-57: 175: 61.21
+	Rn
		709236 HS90B_RAT (19-732): 0: 1063: 86.98		GBRL1_RAT (1-117): 4.54e-56: 171: 100.00
+	Hs
		305908 HS90B_HUMAN (19-732): 0: 1059: 86.13		GBRAP_HUMAN (1-116): 2.96e-56: 171: 87.07
+	Hs
		438517 HS90B_HUMAN (19-732): 0: 1059: 86.13		GBRL1_HUMAN (1-117): 4.54e-56: 171: 100.00
+	Hs
		432262 HS90A_HUMAN (1-732): 0: 1087: 100.00		MLP3A_HUMAN (5-116): 1.09e-44: 142: 34.21
+	Hs
		432242 HS90A_HUMAN (1-732): 0: 1087: 100.00		MLP3B_HUMAN (2-116): 1.06e-43: 140: 31.62
+	Hs
		438528 HS90B_HUMAN (19-732): 0: 1059: 86.13		MLP3A_HUMAN (5-116): 1.09e-44: 142: 34.21
+	Hs
		438507 HS90B_HUMAN (19-732): 0: 1059: 86.13		MLP3B_HUMAN (2-116): 1.06e-43: 140: 31.62
+	Hs
		538179 ENPL_HUMAN (14-701): 0: 898: 46.78		GBRL2_HUMAN (1-116): 1.39e-57: 175: 61.21
+	Hs
		305943 ENPL_HUMAN (14-701): 0: 898: 46.78		GBRAP_HUMAN (1-116): 2.96e-56: 171: 87.07
+	Hs
		538395 ENPL_HUMAN (14-701): 0: 898: 46.78		GBRL1_HUMAN (1-117): 4.54e-56: 171: 100.00
+	Hs
		891146 HS902_HUMAN (1-344): 0: 561: 96.22		GBRL2_HUMAN (1-116): 1.39e-57: 175: 61.21
+	Hs
		1055675 HS902_HUMAN (1-344): 0: 561: 96.22		GBRL1_HUMAN (1-117): 4.54e-56: 171: 100.00
+	Hs
		306174 HS902_HUMAN (1-344): 0: 561: 96.22		GBRAP_HUMAN (1-116): 2.96e-56: 171: 87.07