HitPredict

Interactor 1: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Interactor 2: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway GO:0016310 - phosphorylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 543 Hs			1 1342
+	Hs
		522774 SRC_HUMAN (1-543): 0: 601: 74.22		ERBB3_HUMAN (1-1342): 0: 1388: 100.00
+	Hs
		433359 YES_HUMAN (1-543): 0: 617: 100.00		ERBB4_HUMAN (1-1162): 0: 1152: 50.94
+	Hs
		383538 YES_HUMAN (1-543): 0: 617: 100.00		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		383570 SRC_HUMAN (1-543): 0: 601: 74.22		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		337789 YES_HUMAN (1-543): 0: 617: 100.00		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		337850 SRC_HUMAN (1-543): 0: 601: 74.22		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		337329 SRC_HUMAN (1-543): 0: 601: 74.22		ABL1_HUMAN (696-1307): 5.97e-133: 439: 22.51
+	Hs
		522920 SRC_HUMAN (1-543): 0: 601: 74.22		ROR1_HUMAN (490-1147): 1.55e-126: 416: 17.37
+	Hs
		434125 SRC_HUMAN (1-543): 0: 601: 74.22		RET_HUMAN (518-1072): 1.47e-118: 399: 21.15
+	Hs
		433265 YES_HUMAN (1-543): 0: 617: 100.00		EPHB2_HUMAN (635-993): 1.41e-105: 362: 28.00
+	Hs
		435518 SRC_HUMAN (1-543): 0: 601: 74.22		IGF1R_HUMAN (577-1061): 4.71e-104: 363: 21.00
+	Hs
		522803 SRC_HUMAN (1-543): 0: 601: 74.22		EPHB2_HUMAN (635-993): 1.41e-105: 362: 28.00
+	Hs
		522871 SRC_HUMAN (1-543): 0: 601: 74.22		EPHA4_HUMAN (656-996): 2.83e-103: 354: 27.79
+	Hs
		433331 YES_HUMAN (1-543): 0: 617: 100.00		ACK1_HUMAN (683-961): 1.22e-46: 184: 38.73
+	Hs
		522936 SRC_HUMAN (1-543): 0: 601: 74.22		ACK1_HUMAN (683-961): 1.22e-46: 184: 38.73
+	Hs
		433329 YES_HUMAN (1-543): 0: 617: 100.00		FAK1_HUMAN (713-992): 4.43e-41: 167: 32.19
+	Hs
		111147 YES_HUMAN (1-543): 0: 617: 100.00		I6L996_HUMAN (713-992): 1.5e-41: 166: 32.19
+	Hs
		522840 SRC_HUMAN (1-543): 0: 601: 74.22		ABL2_HUMAN (705-971): 7.69e-43: 173: 36.06
+	Hs
		522802 SRC_HUMAN (1-543): 0: 601: 74.22		EPHA3_HUMAN (691-978): 1.41e-41: 168: 34.13
+	Hs
		522927 SRC_HUMAN (1-543): 0: 601: 74.22		FAK1_HUMAN (713-992): 4.43e-41: 167: 32.19