HitPredict

Interactor 1: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Interactor 2: FLT3 (P36888)
Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135)
Gene: FLT3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	28086240
Identification Methods	protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0004713 - protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 543 Hs			1 993
+	Hs
		522826 SRC_HUMAN (1-543): 0: 601: 74.22		FLT3_HUMAN (1-993): 0: 844: 97.89
+	Hs
		433226 YES_HUMAN (1-543): 0: 617: 100.00		KIT_HUMAN (57-986): 0: 594: 30.44
+	Hs
		426975 YES_HUMAN (1-543): 0: 617: 100.00		CSF1R_HUMAN (66-949): 0: 588: 31.11
+	Hs
		499222 SRC_HUMAN (1-543): 0: 601: 74.22		KIT_HUMAN (57-986): 0: 594: 30.44
+	Hs
		426981 SRC_HUMAN (1-543): 0: 601: 74.22		CSF1R_HUMAN (66-949): 0: 588: 31.11
+	Mm
		403408 SRC_MOUSE (1-543): 0: 598: 73.67		CSF1R_MOUSE (55-948): 0: 586: 30.38
+	Hs
		411962 FYN_HUMAN (1-543): 0: 582: 72.16		KIT_HUMAN (57-986): 0: 594: 30.44
+	Hs
		411943 FYN_HUMAN (1-543): 0: 582: 72.16		CSF1R_HUMAN (66-949): 0: 588: 31.11
+	Mm
		404012 FYN_MOUSE (1-543): 0: 582: 71.98		PGFRB_MOUSE (52-990): 0: 586: 25.91
+	Mm
		452181 FYN_MOUSE (1-543): 0: 582: 71.98		CSF1R_MOUSE (55-948): 0: 586: 30.38
+	Hs
		433247 YES_HUMAN (1-543): 0: 617: 100.00		VGFR1_HUMAN (74-537): 1.47e-36: 152: 14.31
+	Hs
		522825 SRC_HUMAN (1-543): 0: 601: 74.22		VGFR2_HUMAN (55-536): 9.06e-33: 139: 14.02
+	Hs
		411995 FYN_HUMAN (1-543): 0: 582: 72.16		VGFR1_HUMAN (74-537): 1.47e-36: 152: 14.31
+	Hs
		433229 YES_HUMAN (1-543): 0: 617: 100.00		FGFR1_HUMAN (6-360): 2.83e-24: 111: 10.90
+	Hs
		522773 SRC_HUMAN (1-543): 0: 601: 74.22		FGFR2_HUMAN (8-273): 1.07e-26: 119: 11.69
+	Hs
		507818 SRC_HUMAN (1-543): 0: 601: 74.22		FGFR1_HUMAN (6-360): 2.83e-24: 111: 10.90
+	Hs
		412008 FYN_HUMAN (1-543): 0: 582: 72.16		FGFR2_HUMAN (8-273): 1.07e-26: 119: 11.69
+	Hs
		433221 YES_HUMAN (1-543): 0: 617: 100.00		PGFRB_HUMAN (16-230): 1.69e-09: 64: 15.04
+	Hs
		452338 SRC_HUMAN (1-543): 0: 601: 74.22		PGFRB_HUMAN (16-230): 1.69e-09: 64: 15.04
+	Hs
		411953 FYN_HUMAN (1-543): 0: 582: 72.16		PGFRB_HUMAN (16-230): 1.69e-09: 64: 15.04