HitPredict

Interactor 1: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Interactor 2: BCAR1 (P56945)
Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas)
Gene: BCAR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1, SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 543 Hs			1 870
+	Hs
		522874 SRC_HUMAN (1-543): 0: 601: 74.22		BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00
+	Rn
		1144372 SRC_RAT (1-543): 0: 600: 73.67		BCAR1_RAT (2-870): 4.08e-103: 343: 89.12
+	Mm
		403441 SRC_MOUSE (1-543): 0: 598: 73.67		BCAR1_MOUSE (1-870): 1.73e-102: 339: 88.67
+	Hs
		412110 FYN_HUMAN (1-543): 0: 582: 72.16		BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00
+	Rn
		1144044 FYN_RAT (1-543): 0: 581: 71.80		BCAR1_RAT (2-870): 4.08e-103: 343: 89.12
+	Mm
		763397 FYN_MOUSE (1-543): 0: 582: 71.98		BCAR1_MOUSE (1-870): 1.73e-102: 339: 88.67
+	Hs
		442799 HCK_HUMAN (1-541): 0: 544: 57.49		BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00
+	Hs
		412193 FYN_HUMAN (1-543): 0: 582: 72.16		CASL_HUMAN (1-868): 1.02e-91: 309: 35.96
+	Hs
		433331 YES_HUMAN (1-543): 0: 617: 100.00		ACK1_HUMAN (9-499): 2.55e-30: 131: 15.35
+	Hs
		522749 SRC_HUMAN (1-543): 0: 601: 74.22		MUC1_HUMAN (84-764): 2.92e-34: 143: 8.84
+	Hs
		412366 FYN_HUMAN (1-543): 0: 582: 72.16		CASS4_HUMAN (4-865): 6.37e-38: 154: 19.91
+	Hs
		522936 SRC_HUMAN (1-543): 0: 601: 74.22		ACK1_HUMAN (9-499): 2.55e-30: 131: 15.35
+	Hs
		412152 FYN_HUMAN (1-543): 0: 582: 72.16		ACK1_HUMAN (9-499): 2.55e-30: 131: 15.35
+	Hs
		199498 YES_HUMAN (1-543): 0: 617: 100.00		EFS_HUMAN (4-429): 4.35e-14: 78: 22.56
+	Hs
		523104 SRC_HUMAN (1-543): 0: 601: 74.22		SH3K1_HUMAN (7-294): 1.08e-16: 86.7: 16.44
+	Mm
		403448 SRC_MOUSE (1-543): 0: 598: 73.67		EFS_MOUSE (5-378): 5.13e-15: 81.1: 22.61
+	Hs
		199500 SRC_HUMAN (1-543): 0: 601: 74.22		EFS_HUMAN (4-429): 4.35e-14: 78: 22.56
+	Hs
		412296 FYN_HUMAN (1-543): 0: 582: 72.16		SH3K1_HUMAN (7-294): 1.08e-16: 86.7: 16.44
+	Hs
		199497 FYN_HUMAN (1-543): 0: 582: 72.16		EFS_HUMAN (4-429): 4.35e-14: 78: 22.56
+	Hs
		454842 FGR_HUMAN (1-542): 0: 562: 67.10		SH3K1_HUMAN (7-294): 1.08e-16: 86.7: 16.44