HitPredict

Interactor 1: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Interactor 2: ST38L (Q9Y2H1)
Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2)
Gene: STK38L

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 543 Hs			1 464
+	Hs
		325610 SRC_HUMAN (1-543): 0: 601: 74.22		LATS1_HUMAN (7-446): 3.03e-137: 424: 41.13
+	Hs
		523170 SRC_HUMAN (1-543): 0: 601: 74.22		LATS2_HUMAN (7-446): 1.52e-137: 423: 41.00
+	Hs
		411727 LCK_HUMAN (83-541): 0: 540: 60.78		STK38_HUMAN (1-463): 2.34e-164: 473: 86.91
+	Hs
		434089 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		ST38L_HUMAN (12-464): 1.79e-171: 491: 100.00
+	Hs
		522810 SRC_HUMAN (1-543): 0: 601: 74.22		AKT1_HUMAN (35-445): 1.48e-131: 390: 27.40
+	Mm
		403411 SRC_MOUSE (1-543): 0: 598: 73.67		KPCE_MOUSE (2-443): 5.31e-129: 392: 26.22
+	Mm
		403418 SRC_MOUSE (1-543): 0: 598: 73.67		AKT1_MOUSE (35-445): 1.43e-131: 390: 27.17
+	Hs
		412046 FYN_HUMAN (1-543): 0: 582: 72.16		AKT1_HUMAN (35-445): 1.48e-131: 390: 27.40
+	Hs
		411994 FYN_HUMAN (1-543): 0: 582: 72.16		KAPCA_HUMAN (52-433): 1.28e-126: 373: 32.31
+	Mm
		411915 LCK_MOUSE (83-541): 0: 542: 60.78		KPCE_MOUSE (2-443): 5.31e-129: 392: 26.22
+	Hs
		789133 FRK_HUMAN (71-535): 1.11e-172: 499: 48.25		LATS2_HUMAN (7-446): 1.52e-137: 423: 41.00
+	Hs
		337568 ABL1_HUMAN (41-543): 5.93e-161: 489: 39.10		LATS2_HUMAN (7-446): 1.52e-137: 423: 41.00
+	Hs
		433609 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		AKT2_HUMAN (35-445): 2.3e-130: 387: 25.94
+	Hs
		681838 PTK6_HUMAN (88-536): 9.35e-164: 474: 42.73		AKT1_HUMAN (35-445): 1.48e-131: 390: 27.40
+	Hs
		411908 LCK_HUMAN (83-541): 0: 540: 60.78		MRCKB_HUMAN (65-464): 4.59e-90: 301: 41.69
+	Hs
		411758 LCK_HUMAN (83-541): 0: 540: 60.78		MRCKA_HUMAN (79-455): 2.05e-89: 300: 43.15
+	Hs
		434101 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		MRCKB_HUMAN (65-464): 4.59e-90: 301: 41.69
+	Hs
		433818 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		MRCKA_HUMAN (79-455): 2.05e-89: 300: 43.15
+	Hs
		433749 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		ROCK1_HUMAN (71-416): 4.2e-82: 278: 43.18