HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: PLCH1 (Q4KWH8)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3)
Gene: PLCH1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C2~SH2
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 512 Hs			1 1693
+	Hs
		411745 LCK_HUMAN (1-512): 0: 582: 63.62		PLCH1_HUMAN (1-1693): 0: 2265: 100.00
+	Hs
		434024 LYN_HUMAN (1-512): 0: 611: 100.00		PLCB1_HUMAN (21-1008): 0: 603: 16.71
+	Hs
		846042 SRMS_HUMAN (36-505): 3.31e-159: 463: 38.03		PLCD1_HUMAN (1-857): 0: 666: 28.06
+	Mm
		639456 LYN_MOUSE (1-512): 0: 612: 96.09		PLCG2_MOUSE (546-858): 5.33e-77: 283: 31.10
+	Hs
		433564 LYN_HUMAN (1-512): 0: 611: 100.00		PLCG2_HUMAN (592-858): 1.91e-75: 278: 35.38
+	Hs
		522758 SRC_HUMAN (1-510): 0: 580: 51.97		PLCG1_HUMAN (547-921): 9.5e-78: 286: 29.82
+	Hs
		412000 FYN_HUMAN (1-510): 0: 576: 54.12		PLCG1_HUMAN (547-921): 9.5e-78: 286: 29.82
+	Mm
		763400 FYN_MOUSE (1-510): 0: 576: 53.93		PLCG2_MOUSE (546-858): 5.33e-77: 283: 31.10
+	Hs
		411992 FYN_HUMAN (1-510): 0: 576: 54.12		PLCG2_HUMAN (592-858): 1.91e-75: 278: 35.38
+	Mm
		557351 BLK_MOUSE (1-512): 0: 545: 61.40		PLCG2_MOUSE (546-858): 5.33e-77: 283: 31.10
+	Hs
		562634 BLK_HUMAN (1-512): 0: 544: 60.00		PLCG2_HUMAN (592-858): 1.91e-75: 278: 35.38
+	Hs
		580953 ABL2_HUMAN (14-509): 1.38e-171: 517: 36.61		PLCG1_HUMAN (547-921): 9.5e-78: 286: 29.82
+	Hs
		337341 ABL1_HUMAN (32-509): 9.04e-172: 516: 37.88		PLCG1_HUMAN (547-921): 9.5e-78: 286: 29.82
+	Mm
		623690 TEC_MOUSE (35-505): 3.35e-159: 468: 35.76		PLCG1_MOUSE (430-941): 1.03e-81: 298: 24.76
+	Hs
		580990 ITK_HUMAN (35-503): 3.09e-162: 475: 35.83		PLCG1_HUMAN (547-921): 9.5e-78: 286: 29.82
+	Mm
		729760 BTK_MOUSE (30-505): 1.49e-157: 465: 35.03		PLCG2_MOUSE (546-858): 5.33e-77: 283: 31.10
+	Hs
		562642 BTK_HUMAN (2-505): 1.48e-156: 462: 33.86		PLCG2_HUMAN (592-858): 1.91e-75: 278: 35.38