Protein: RTCA
RNA 3'-terminal phosphate cyclase (RNA cyclase) (RNA-3'-phosphate cyclase) (EC 6.5.1.4) (RNA terminal phosphate cyclase domain-containing protein 1) (RTC domain-containing protein 1)

Gene: RTCA
Organism: Homo sapiens
Interactions: 96
UniProt ID: O00442

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003963 - RNA-3'-phosphate cyclase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

135763

MYC
Myc proto-oncogene protein

2

3

High-throughput

0.584

High

135782

OTX2
Homeobox protein OTX2

2

0

High-throughput

0.580

High

135806

KPCD1
Serine/threonine-protein kinase D1

2

0

High-throughput

0.547

High

135755

FOXS1
Forkhead box protein S1

1

1

High-throughput

0.536

High

135780

SPB3
Serpin B3

1

2

High-throughput

0.536

High

135788

RS10
Small ribosomal subunit protein eS10

1

1

High-throughput

0.536

High

135828

FOXQ1
Forkhead box protein Q1

1

2

High-throughput

0.536

High

135775

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

2

High-throughput

0.515

High

135797

RL23A
Large ribosomal subunit protein uL23

1

1

High-throughput

0.515

High

135834

DDX21
Nucleolar RNA helicase 2

1

1

High-throughput

0.515

High

74388

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

0

High-throughput

0.513

High

135762

CYTA
Cystatin-A

1

0

High-throughput

0.513

High

135799

HXC5
Homeobox protein Hox-C5

1

0

High-throughput

0.513

High

135812

UBP45
Ubiquitin carboxyl-terminal hydrolase 45

1

0

High-throughput

0.513

High

135814

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

135816

ZN695
Zinc finger protein 695

1

0

High-throughput

0.513

High

135817

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

135818

ARI1B
AT-rich interactive domain-containing protein 1B

1

0

High-throughput

0.513

High

135820

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

135754

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

0

High-throughput

0.493

High

135802

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.493

High

135790

SPB4
Serpin B4

1

2

High-throughput

0.489

High

135804

SLAF1
Signaling lymphocytic activation molecule

1

1

High-throughput

0.489

High

135813

S1A7A
Protein S100-A7A

1

1

High-throughput

0.489

High

135836

CRNN
Cornulin

1

1

High-throughput

0.489

High

135761

SNAI1
Zinc finger protein SNAI1

1

1

High-throughput

0.479

High

135765

MYCN
N-myc proto-oncogene protein

1

3

High-throughput

0.479

High

135767

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.479

High

135770

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

135774

LMNB1
Lamin-B1

1

1

High-throughput

0.479

High

135779

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

135784

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

135792

FOXL2
Forkhead box protein L2

1

1

High-throughput

0.479

High

135793

RL26
Large ribosomal subunit protein uL24

1

1

High-throughput

0.479

High

135794

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

135795

RS11
Small ribosomal subunit protein uS17

1

1

High-throughput

0.479

High

135803

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

135827

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

1

High-throughput

0.479

High

135837

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

135844

MAFB
Transcription factor MafB

1

2

High-throughput

0.479

High

135757

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

135759

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

135773

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.458

High

135783

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

135786

RL21
Large ribosomal subunit protein eL21

1

0

High-throughput

0.458

High

135787

RL28
Large ribosomal subunit protein eL28

1

0

High-throughput

0.458

High

135789

RL29
Large ribosomal subunit protein eL29

1

0

High-throughput

0.458

High

135798

RL32
Large ribosomal subunit protein eL32

1

0

High-throughput

0.458

High

135805

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.458

High

135823

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.458

High

135826

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

135830

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

135833

MRM3
rRNA methyltransferase 3, mitochondrial

1

0

High-throughput

0.458

High

135838

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

135842

SF3B6
Splicing factor 3B subunit 6

1

0

High-throughput

0.458

High

135843

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.458

High

135766

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

135835

DDX28
Probable ATP-dependent RNA helicase DDX28

1

2

High-throughput

0.445

High

75632

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

1

High-throughput

0.437

High

135809

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.437

High

135810

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

135822

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.437

High

135831

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

135756

PRKY
Putative serine/threonine-protein kinase PRKY

1

0

High-throughput

0.426

High

135771

NCK1
SH2/SH3 adapter protein NCK1

1

0

High-throughput

0.426

High

135781

1433S
14-3-3 protein sigma

1

0

High-throughput

0.426

High

135829

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

135841

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.426

High

69452

A2ML1
Alpha-2-macroglobulin-like protein 1

1

1

High-throughput

0.407

High

135825

GORS1
Golgi reassembly-stacking protein 1

2

0

High-throughput

0.328

High

135832

RSAD1
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial

2

0

High-throughput

0.313

High

73745

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

0

High-throughput

0.279

Low

135753

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.279

Low

135760

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

0

High-throughput

0.279

Low

135768

PAEP
Glycodelin

1

0

High-throughput

0.279

Low

135769

PPBI
Intestinal-type alkaline phosphatase

1

0

High-throughput

0.279

Low

135772

SAP3
Ganglioside GM2 activator

1

0

High-throughput

0.279

Low

135776

IDS
Iduronate 2-sulfatase

1

0

High-throughput

0.279

Low

135777

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

0

High-throughput

0.279

Low

135778

CAH6
Carbonic anhydrase 6

1

0

High-throughput

0.279

Low

135801

CNTN2
Contactin-2

1

0

High-throughput

0.279

Low

135807

AMOT
Angiomotin

1

0

High-throughput

0.279

Low

135808

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.279

Low

135811

FBX50
F-box only protein 50

1

0

High-throughput

0.279

Low

135815

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

0

High-throughput

0.279

Low

135819

POF1B
Protein POF1B

1

0

High-throughput

0.279

Low

135821

ESPB1
Epididymal sperm-binding protein 1

1

0

High-throughput

0.279

Low

135824

LPAR4
Lysophosphatidic acid receptor 4

1

0

High-throughput

0.279

Low

135839

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

0

High-throughput

0.279

Low

135840

LAMP3
Lysosome-associated membrane glycoprotein 3

1

0

High-throughput

0.279

Low

135764

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.249

Low

135785

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.249

Low

135796

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.249

Low

135758

GSDME
Gasdermin-E

1

0

High-throughput

0.232

Low

135791

FNTA
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

1

0

High-throughput

0.232

Low

135800

TAGL
Transgelin

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025