HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: PTN1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Gene: PTPN1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	32062451, 35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005769 - early endosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 435
+	Hs
		434120 RET_HUMAN (1-1114): 0: 1295: 100.00		PTPRF_HUMAN (19-278): 2.99e-105: 344: 30.94
+	Hs
		434133 RET_HUMAN (1-1114): 0: 1295: 100.00		PTPRA_HUMAN (12-278): 9.1e-105: 330: 31.62
+	Hs
		434178 RET_HUMAN (1-1114): 0: 1295: 100.00		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Hs
		507839 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		PTN1_HUMAN (1-435): 0: 539: 100.00
+	Hs
		601500 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		PTN12_HUMAN (24-314): 1e-122: 376: 33.55
+	Hs
		983487 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		PTN12_HUMAN (24-314): 1e-122: 376: 33.55
+	Mm
		728828 EGFR_MOUSE (426-1113): 8.96e-142: 459: 22.83		PTN12_MOUSE (24-314): 2.72e-120: 369: 32.68
+	Hs
		507980 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		PTPRS_HUMAN (1-278): 3.66e-109: 355: 30.74
+	Hs
		337831 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		PTPRF_HUMAN (19-278): 2.99e-105: 344: 30.94
+	Hs
		337802 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		PTPRC_HUMAN (16-337): 3.28e-77: 263: 22.95
+	Hs
		146927 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		PTPRT_HUMAN (6-278): 5.46e-63: 222: 26.57
+	Hs
		146919 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		PTPRT_HUMAN (6-278): 5.46e-63: 222: 26.57
+	Hs
		601501 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Hs
		507959 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Hs
		1071017 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		PTPRH_HUMAN (11-300): 1.33e-48: 180: 35.71
+	Hs
		985960 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Hs
		609260 FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Mm
		719299 EGFR_MOUSE (426-1113): 8.96e-142: 459: 22.83		PTN11_MOUSE (39-274): 4.54e-49: 177: 38.80
+	Hs
		601466 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		PTN6_HUMAN (342-432): 1.75e-12: 71.2: 10.48
+	Hs
		665895 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		PTN6_HUMAN (342-432): 1.75e-12: 71.2: 10.48