HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	15485908, 12637586, 11536047
Identification Methods	affinity chromatography technology, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0010628 - positive regulation of gene expression GO:0030335 - positive regulation of cell migration GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 770
+	Hs
		601474 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		507894 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		609197 FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		338060 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		383662 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		729621 VGFR2_HUMAN (344-1105): 2.13e-137: 451: 23.91		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		384414 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Mm
		786519 ERBB2_MOUSE (426-1113): 1.04e-135: 444: 23.92		STAT3_MOUSE (1-770): 0: 1049: 99.87
+	Hs
		338072 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		383667 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		729622 VGFR2_HUMAN (344-1105): 2.13e-137: 451: 23.91		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		384428 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		338166 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		STAT2_HUMAN (1-728): 0: 786: 38.47
+	Hs
		601481 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		601477 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Hs
		849893 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		786612 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Hs
		338153 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		338073 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Hs
		384522 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		STA5B_HUMAN (1-734): 0: 752: 30.55