HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.920

Property	Details
Experiments	32062451, 10995764, 8183561, 7665556, 15677445
Identification Methods	proximity labelling technology, pull down, affinity chromatography technology
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 217
+	Hs
		434130 RET_HUMAN (1-1114): 0: 1295: 100.00		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		434125 RET_HUMAN (1-1114): 0: 1295: 100.00		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Mm
		403421 RET_MOUSE (1-1114): 0: 1275: 83.24		SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		601492 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		507939 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Rn
		728442 NTRK1_RAT (376-1018): 1.45e-149: 468: 24.47		GRB2_RAT (1-217): 6.71e-76: 229: 100.00
+	Hs
		507989 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		PTK6_HUMAN (4-141): 7.14e-23: 97.1: 38.93
+	Hs
		507832 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		507897 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		337480 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		601605 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67
+	Hs
		412008 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433573 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		522773 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		508233 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67
+	Hs
		507829 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37
+	Hs
		433229 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		508022 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00
+	Hs
		507818 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		275197 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		GRAP2_HUMAN (3-55): 1.58e-10: 61.3: 39.62