HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 593
+	Hs
		434120 RET_HUMAN (1-1114): 0: 1295: 100.00		PTPRF_HUMAN (33-522): 2.6e-112: 371: 25.85
+	Hs
		434133 RET_HUMAN (1-1114): 0: 1295: 100.00		PTPRA_HUMAN (33-522): 7.08e-110: 349: 23.72
+	Hs
		434132 RET_HUMAN (1-1114): 0: 1295: 100.00		PTN1_HUMAN (232-541): 4.38e-110: 338: 31.63
+	Hs
		601501 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		507959 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		985960 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		609260 FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Mm
		719299 EGFR_MOUSE (426-1113): 8.96e-142: 459: 22.83		PTN11_MOUSE (1-593): 0: 580: 99.49
+	Hs
		601466 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		665895 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		507980 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		PTPRS_HUMAN (39-522): 8.52e-117: 384: 26.76
+	Hs
		508134 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		PTPR2_HUMAN (135-531): 5.92e-113: 362: 30.15
+	Hs
		337831 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		PTPRF_HUMAN (33-522): 2.6e-112: 371: 25.85
+	Hs
		507839 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		PTN1_HUMAN (232-541): 4.38e-110: 338: 31.63
+	Hs
		337909 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		PTPRA_HUMAN (33-522): 7.08e-110: 349: 23.72
+	Hs
		337903 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		PTN1_HUMAN (232-541): 4.38e-110: 338: 31.63
+	Hs
		337802 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		PTPRC_HUMAN (33-579): 2.25e-85: 291: 18.29
+	Hs
		146927 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		PTPRT_HUMAN (35-524): 6.59e-70: 247: 18.90
+	Hs
		146919 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		PTPRT_HUMAN (35-524): 6.59e-70: 247: 18.90
+	Hs
		337897 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		PTN2_HUMAN (263-518): 6.71e-51: 182: 39.00