Protein: PTTG1
Securin (Esp1-associated protein) (Pituitary tumor-transforming gene 1 protein) (Tumor-transforming protein 1) (hPTTG)

Gene: PTTG1
Organism: Homo sapiens
Interactions: 60
UniProt ID: O95997

Gene Ontology (top 5):
GO:0004869 - cysteine-type endopeptidase inhibitor activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006281 - DNA repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

330200

ESPL1
Separin

9

0

Small-scale

0.925

High

330196

CDC20
Cell division cycle protein 20 homolog

28

1

Small-scale

0.769

High

330216

FZR1
Fizzy-related protein homolog

23

1

Small-scale

0.767

High

330179

CDC27
Cell division cycle protein 27 homolog

5

0

Small-scale

0.680

High

330202

DECR
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial

4

0

High-throughput

0.667

High

330213

APC11
Anaphase-promoting complex subunit 11

3

0

Small-scale

0.627

High

330169

P53
Cellular tumor antigen p53

2

0

Small-scale

0.603

High

330215

ANC2
Anaphase-promoting complex subunit 2

2

1

Small-scale

0.602

High

330182

CRK
Adapter molecule crk

2

1

High-throughput

0.576

High

330175

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

2

0

High-throughput

0.569

High

330204

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

0

Small-scale

0.561

High

236864

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

2

Small-scale

0.561

High

330188

PTTG
Pituitary tumor-transforming gene 1 protein-interacting protein

1

0

Small-scale

0.549

High

330180

DNJA1
DnaJ homolog subfamily A member 1

1

0

Small-scale

0.537

High

330184

RS10
Small ribosomal subunit protein eS10

1

0

Small-scale

0.537

High

330197

CUL1
Cullin-1

1

0

Small-scale

0.537

High

330173

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

235646

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.513

High

317389

YETS4
YEATS domain-containing protein 4

1

0

High-throughput

0.513

High

330183

BAG6
Large proline-rich protein BAG6

1

0

High-throughput

0.513

High

330189

PMS1
PMS1 protein homolog 1

1

0

High-throughput

0.513

High

330203

ACTBL
Beta-actin-like protein 2

1

0

High-throughput

0.513

High

330205

TTLL5
Tubulin polyglutamylase TTLL5

1

0

High-throughput

0.513

High

330206

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

0

High-throughput

0.513

High

330207

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

0

High-throughput

0.513

High

330171

XRCC6
X-ray repair cross-complementing protein 6

1

0

Small-scale

0.504

High

330168

PTTG1
Securin

1

0

High-throughput

0.493

High

160310

AURKA
Aurora kinase A

1

0

Small-scale

0.480

High

226182

PRKN
E3 ubiquitin-protein ligase parkin

1

0

Small-scale

0.480

High

283128

ZFAN5
AN1-type zinc finger protein 5

1

0

Small-scale

0.480

High

330185

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

Small-scale

0.480

High

330191

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

Small-scale

0.480

High

330198

UBE4A
Ubiquitin conjugation factor E4 A

1

0

Small-scale

0.480

High

330201

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

0

Small-scale

0.480

High

330210

APC1
Anaphase-promoting complex subunit 1

1

0

Small-scale

0.480

High

330214

APC4
Anaphase-promoting complex subunit 4

1

0

Small-scale

0.480

High

330217

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

0

Small-scale

0.480

High

330177

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

1

Small-scale

0.479

High

330178

MK01
Mitogen-activated protein kinase 1

1

1

Small-scale

0.479

High

330181

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

1

Small-scale

0.479

High

330190

RD23A
UV excision repair protein RAD23 homolog A

1

1

Small-scale

0.479

High

162317

XPO1
Exportin-1

1

0

High-throughput

0.458

High

208234

DCX
Neuronal migration protein doublecortin

1

0

Small-scale

0.458

High

330174

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.458

High

330176

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.458

High

330186

CEBPD
CCAAT/enhancer-binding protein delta

1

0

Small-scale

0.458

High

330187

NUP98
Nuclear pore complex protein Nup98-Nup96

1

0

Small-scale

0.458

High

330192

RS14
Small ribosomal subunit protein uS11

1

0

Small-scale

0.458

High

330193

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

0

Small-scale

0.458

High

330194

RAE1L
mRNA export factor RAE1

1

0

Small-scale

0.458

High

330209

UBP44
Ubiquitin carboxyl-terminal hydrolase 44

1

0

Small-scale

0.458

High

330211

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

0

Small-scale

0.458

High

330218

FBW1A
F-box/WD repeat-containing protein 1A

1

0

Small-scale

0.458

High

330199

KEAP1
Kelch-like ECH-associated protein 1

1

0

High-throughput

0.391

High

330195

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

1

0

High-throughput

0.279

Low

330208

RM01
Large ribosomal subunit protein uL1m

1

0

High-throughput

0.279

Low

330212

ZCC17
Zinc finger CCHC domain-containing protein 17

1

0

High-throughput

0.279

Low

330170

CADH1
Cadherin-1

1

0

Small-scale

0.261

Low

330172

LYL1
Protein lyl-1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024