HitPredict

Interactor 1: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Interactor 2: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	28205554
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Pkinase~fn3, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0007165 - signal transduction GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1367 Hs			1 303
+	Hs
		435611 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		CDK3_HUMAN (3-302): 7.81e-139: 395: 44.74
+	Hs
		414687 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24
+	Hs
		411301 INSR_HUMAN (32-1365): 0: 1219: 56.54		CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22
+	Hs
		515342 EPHA2_HUMAN (653-1304): 6.11e-163: 516: 23.93		CDK4_HUMAN (1-303): 2.42e-128: 369: 100.00
+	Hs
		665211 EPHA2_HUMAN (653-1304): 6.11e-163: 516: 23.93		CDK6_HUMAN (5-300): 4.03e-127: 367: 70.03
+	Hs
		384287 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22
+	Hs
		507863 FGFR1_HUMAN (972-1266): 1.32e-64: 238: 39.54		CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22
+	Hs
		609180 FGFR3_HUMAN (972-1266): 2.05e-63: 234: 38.44		CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22
+	Hs
		384094 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24
+	Hs
		384174 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		CDK4_HUMAN (1-303): 2.42e-128: 369: 100.00
+	Hs
		384654 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		CDK6_HUMAN (5-300): 4.03e-127: 367: 70.03
+	Hs
		384655 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		CDK5_HUMAN (3-301): 5.52e-124: 357: 43.09
+	Hs
		414702 FGFR1_HUMAN (972-1266): 1.32e-64: 238: 39.54		CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24
+	Mm
		546285 NTRK2_MOUSE (977-1262): 3.02e-69: 252: 43.05		CDK5_MOUSE (3-301): 6.95e-124: 357: 43.09
+	Hs
		414934 NTRK3_HUMAN (977-1262): 5.74e-64: 236: 39.16		CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24
+	Rn
		728443 NTRK1_RAT (977-1262): 4.08e-69: 251: 41.92		CDK5_RAT (3-301): 2.58e-123: 356: 43.42
+	Rn
		974744 NTRK2_RAT (977-1262): 3.63e-69: 251: 43.05		CDK5_RAT (3-301): 2.58e-123: 356: 43.42
+	Hs
		414738 FGFR3_HUMAN (972-1266): 2.05e-63: 234: 38.44		CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24