Protein: MK01
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)

Gene: MK01, Mapk1
Organism: Rattus norvegicus
Interactions: 168
UniProt ID: P63086

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001784 - phosphotyrosine residue binding
GO:0003690 - double-stranded DNA binding
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

989638

DCC
Netrin receptor DCC

1

2

Small-scale

0.786

High

639965

MK03
Mitogen-activated protein kinase 3

2

18

Small-scale

0.737

High

989644

DUS6
Dual specificity protein phosphatase 6

1

20

Small-scale

0.647

High

147597

DGKZ
Diacylglycerol kinase zeta

1

4

High-throughput

0.618

High

479896

KPCE
Protein kinase C epsilon type

1

9

High-throughput

0.618

High

482174

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit [Cleaved into: cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed]

1

5

High-throughput

0.618

High

553462

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

4

High-throughput

0.618

High

553465

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

4

High-throughput

0.618

High

561017

KCC4
Calcium/calmodulin-dependent protein kinase type IV

1

14

High-throughput

0.618

High

613669

GSK3B
Glycogen synthase kinase-3 beta

1

20

High-throughput

0.618

High

885018

DGKG
Diacylglycerol kinase gamma

1

11

High-throughput

0.618

High

885019

DGKB
Diacylglycerol kinase beta

1

10

High-throughput

0.618

High

989420

DNJA1
DnaJ homolog subfamily A member 1

1

7

High-throughput

0.618

High

989593

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

6

High-throughput

0.618

High

989594

KPCB
Protein kinase C beta type

1

9

High-throughput

0.618

High

989595

FAK2
Protein-tyrosine kinase 2-beta

1

5

High-throughput

0.618

High

989599

KALRN
Kalirin

1

5

High-throughput

0.618

High

989604

SRSF5
Serine/arginine-rich splicing factor 5

1

9

High-throughput

0.618

High

989608

Q3SWU5
Protein kinase, cAMP dependent regulatory, type I, beta

1

5

High-throughput

0.618

High

989623

DCLK2
Serine/threonine-protein kinase DCLK2

1

17

High-throughput

0.618

High

989628

RHEB
GTP-binding protein Rheb

1

1

High-throughput

0.618

High

989629

CAPS1
Calcium-dependent secretion activator 1

1

1

High-throughput

0.618

High

989631

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

6

High-throughput

0.618

High

989634

ROCK2
Rho-associated protein kinase 2

1

6

High-throughput

0.618

High

989637

CAMKV
CaM kinase-like vesicle-associated protein

1

15

High-throughput

0.618

High

989641

CDC37
Hsp90 co-chaperone Cdc37

1

8

High-throughput

0.618

High

989642

RAB3D
GTP-binding protein Rab-3D

1

1

High-throughput

0.618

High

989651

PHIPL
Phytanoyl-CoA hydroxylase-interacting protein-like

1

1

High-throughput

0.618

High

989664

PPM1E
Protein phosphatase 1E

1

14

High-throughput

0.618

High

989665

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

5

High-throughput

0.618

High

989666

CSKI1
Caskin-1

1

6

High-throughput

0.618

High

989676

GIT1
ARF GTPase-activating protein GIT1

1

7

High-throughput

0.618

High

989660

RAC1
Ras-related C3 botulinum toxin substrate 1

1

0

Small-scale

0.586

High

989613

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

7

High-throughput

0.553

High

989653

TANC1
Protein TANC1

1

5

High-throughput

0.553

High

98623

F1LSE6
PTPRF interacting protein alpha 3

1

0

High-throughput

0.517

High

790660

CNN3
Calponin-3

1

4

Small-scale

0.512

High

388098

MBP
Myelin basic protein

1

6

Small-scale

0.501

High

788564

SCNNB
Epithelial sodium channel subunit beta

1

1

Small-scale

0.501

High

788566

SCNNG
Epithelial sodium channel subunit gamma

1

1

Small-scale

0.501

High

989602

CNN1
Calponin-1

1

7

Small-scale

0.501

High

92848

H15
Histone H1.5

1

2

High-throughput

0.479

High

93004

TRIM2
Tripartite motif-containing protein 2

1

6

High-throughput

0.479

High

98597

F1LPP6
A-kinase anchoring protein 5

1

4

High-throughput

0.479

High

98730

F1LST4
Microtubule-associated protein

1

10

High-throughput

0.479

High

98857

RPGF2
Rap guanine nucleotide exchange factor 2

1

3

High-throughput

0.479

High

204940

RABE1
Rab GTPase-binding effector protein 1

1

2

High-throughput

0.479

High

205731

SH3G1
Endophilin-A2

1

2

High-throughput

0.479

High

266831

TRIM3
Tripartite motif-containing protein 3

1

6

High-throughput

0.479

High

504826

MAP1S
Microtubule-associated protein 1S

1

4

High-throughput

0.479

High

561714

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

3

High-throughput

0.479

High

633964

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

1

8

High-throughput

0.479

High

663837

RS27L
Small ribosomal subunit protein eS27-like

1

1

High-throughput

0.479

High

722680

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

11

High-throughput

0.479

High

723867

DLG4
Disks large homolog 4

1

9

High-throughput

0.479

High

770791

PGH2
Prostaglandin G/H synthase 2

1

2

Small-scale

0.479

High

835040

TOP2A
DNA topoisomerase 2-alpha

1

3

High-throughput

0.479

High

866424

RP3A
Rabphilin-3A

1

1

High-throughput

0.479

High

880439

RS3A
Small ribosomal subunit protein eS1

1

1

High-throughput

0.479

High

911718

AP1B1
AP-1 complex subunit beta-1

1

3

High-throughput

0.479

High

914921

PYC
Pyruvate carboxylase, mitochondrial

1

6

High-throughput

0.479

High

949117

RUVB1
RuvB-like 1

1

7

High-throughput

0.479

High

967636

RS7
Small ribosomal subunit protein eS7

1

1

High-throughput

0.479

High

968859

PRS4
26S proteasome regulatory subunit 4

1

2

High-throughput

0.479

High

969118

PRS8
26S proteasome regulatory subunit 8

1

3

High-throughput

0.479

High

978825

RL23A
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

986879

AP2B1
AP-2 complex subunit beta

1

3

High-throughput

0.479

High

989597

AP2M1
AP-2 complex subunit mu

1

2

High-throughput

0.479

High

989598

EFTU
Elongation factor Tu, mitochondrial

1

10

High-throughput

0.479

High

989600

MECP2
Methyl-CpG-binding protein 2

1

3

High-throughput

0.479

High

989601

H2B1
Histone H2B type 1

1

9

High-throughput

0.479

High

989603

PGTA
Geranylgeranyl transferase type-2 subunit alpha

1

4

High-throughput

0.479

High

989605

CRTC1
CREB-regulated transcription coactivator 1

1

3

High-throughput

0.479

High

989606

KINH
Kinesin-1 heavy chain

1

1

High-throughput

0.479

High

989607

IF4A3
Eukaryotic initiation factor 4A-III

1

6

High-throughput

0.479

High

989610

COPG1
Coatomer subunit gamma-1

1

4

High-throughput

0.479

High

989611

STML2
Stomatin-like protein 2, mitochondrial

1

1

High-throughput

0.479

High

989612

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

3

High-throughput

0.479

High

989615

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

1

High-throughput

0.479

High

989616

PHYIP
Phytanoyl-CoA hydroxylase-interacting protein

1

1

High-throughput

0.479

High

989617

Q56R20
Importin subunit alpha

1

1

High-throughput

0.479

High

989618

ARHG2
Rho guanine nucleotide exchange factor 2

1

5

High-throughput

0.479

High

989619

Q5FVT5
Protein-serine/threonine kinase

1

1

High-throughput

0.479

High

989622

MAP4
Microtubule-associated protein 4

1

11

High-throughput

0.479

High

989624

AKA12
A-kinase anchor protein 12

1

5

High-throughput

0.479

High

989627

MARE3
Microtubule-associated protein RP/EB family member 3

1

2

High-throughput

0.479

High

989632

RABE2
Rab GTPase-binding effector protein 2

1

1

High-throughput

0.479

High

989635

SYNJ1
Synaptojanin-1

1

2

High-throughput

0.479

High

989636

DLG3
Disks large homolog 3

1

7

High-throughput

0.479

High

989639

PRS7
26S proteasome regulatory subunit 7

1

2

High-throughput

0.479

High

989640

MAP6
Microtubule-associated protein 6

1

6

High-throughput

0.479

High

989646

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

3

High-throughput

0.479

High

989647

PDK2
[Pyruvate dehydrogenase

1

1

High-throughput

0.479

High

989649

SND1
Staphylococcal nuclease domain-containing protein 1

1

1

High-throughput

0.479

High

989652

RTCB
RNA-splicing ligase RtcB homolog

1

1

High-throughput

0.479

High

989658

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.479

High

989661

RS27
Small ribosomal subunit protein eS27

1

1

High-throughput

0.479

High

989662

SRR
Serine racemase

1

3

High-throughput

0.479

High

989663

FMR1
Fragile X messenger ribonucleoprotein 1

1

3

High-throughput

0.479

High

989667

ELP1
Elongator complex protein 1

1

1

High-throughput

0.479

High

989669

ACBG1
Long-chain-fatty-acid--CoA ligase ACSBG1

1

2

High-throughput

0.479

High

989670

LONM
Lon protease homolog, mitochondrial

1

5

High-throughput

0.479

High

989671

CLAP2
CLIP-associating protein 2

1

2

High-throughput

0.479

High

989672

WDR7
WD repeat-containing protein 7

1

7

High-throughput

0.479

High

989673

DBNL
Drebrin-like protein

1

4

High-throughput

0.479

High

989674

DCTN4
Dynactin subunit 4

1

1

High-throughput

0.479

High

989675

PDE10
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

1

1

High-throughput

0.479

High

72720

B0K031
Large ribosomal subunit protein uL30

1

0

High-throughput

0.458

High

108196

G3V8L9
Caveolae associated protein 1

1

0

High-throughput

0.458

High

148454

MADD
MAP kinase-activating death domain protein

1

0

High-throughput

0.458

High

266916

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.458

High

312648

PACS1
Phosphofurin acidic cluster sorting protein 1

1

0

High-throughput

0.458

High

383220

RLA2
Large ribosomal subunit protein P2

1

0

High-throughput

0.458

High

488035

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.458

High

550806

RL18
Large ribosomal subunit protein eL18

1

0

High-throughput

0.458

High

560147

SUCA
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

614757

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.458

High

627067

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.458

High

631852

FCERG
High affinity immunoglobulin epsilon receptor subunit gamma

1

0

Small-scale

0.458

High

638769

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

657338

RL12
Large ribosomal subunit protein uL11

1

0

High-throughput

0.458

High

663834

RL17
Large ribosomal subunit protein uL22

1

0

High-throughput

0.458

High

700322

DCTN1
Dynactin subunit 1

1

0

High-throughput

0.458

High

710071

RS9
Small ribosomal subunit protein uS4

1

0

High-throughput

0.458

High

790140

KLC1
Kinesin light chain 1

1

0

High-throughput

0.458

High

810493

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.458

High

832251

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.458

High

847048

H10
Histone H1.0

1

0

High-throughput

0.458

High

898267

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.458

High

960966

RL15
Large ribosomal subunit protein eL15

1

0

High-throughput

0.458

High

973364

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

976059

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.458

High

977449

RS4X
Small ribosomal subunit protein eS4

1

0

High-throughput

0.458

High

977662

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.458

High

979409

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

982608

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

984615

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.458

High

985398

RL10A
Large ribosomal subunit protein uL1

1

0

High-throughput

0.458

High

989596

RL24
Large ribosomal subunit protein eL24

1

0

High-throughput

0.458

High

989609

ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial

1

0

High-throughput

0.458

High

989614

ROGDI
Protein rogdi homolog

1

0

High-throughput

0.458

High

989620

IMPCT
Protein IMPACT

1

0

High-throughput

0.458

High

989621

PI51C
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

1

0

High-throughput

0.458

High

989625

Q5RK10
Large ribosomal subunit protein uL13

1

0

High-throughput

0.458

High

989626

PITM1
Membrane-associated phosphatidylinositol transfer protein 1

1

0

High-throughput

0.458

High

989630

EXOC4
Exocyst complex component 4

1

0

High-throughput

0.458

High

989633

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.458

High

989645

LXN
Latexin

1

0

High-throughput

0.458

High

989655

NDRG1
Protein NDRG1

1

0

High-throughput

0.458

High

989656

HP1B3
Heterochromatin protein 1-binding protein 3

1

0

High-throughput

0.458

High

989657

SYWC
Tryptophan--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

989659

ATLA1
Atlastin-1

1

0

High-throughput

0.458

High

989668

ASGL1
Isoaspartyl peptidase/L-asparaginase

1

0

High-throughput

0.458

High

620039

TAU
Microtubule-associated protein tau

1

9

High-throughput

0.445

High

620998

GLUT4
Solute carrier family 2, facilitated glucose transporter member 4

1

4

High-throughput

0.445

High

108129

G3V6I9
Large ribosomal subunit protein uL24

1

1

High-throughput

0.437

High

954348

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.437

High

973660

RS11
Small ribosomal subunit protein uS17

1

1

High-throughput

0.437

High

989648

Q66HM2
AP-2 complex subunit alpha

1

4

High-throughput

0.437

High

989650

RPAP3
RNA polymerase II-associated protein 3

1

2

High-throughput

0.437

High

989654

Q6GMM8
Arachidonate--CoA ligase

1

2

High-throughput

0.437

High

108190

G3V8J5
Pleckstrin and Sec7 domain containing

1

0

High-throughput

0.249

Low

108212

G3V8V3
Alpha-1,4 glucan phosphorylase

1

0

High-throughput

0.249

Low

969558

RS8
Small ribosomal subunit protein eS8

1

0

High-throughput

0.249

Low

970208

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.249

Low

972815

RS23
Small ribosomal subunit protein uS12

1

0

High-throughput

0.249

Low

982912

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.249

Low

989643

Q642E2
Large ribosomal subunit protein eL28

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025