HitPredict

Interactor 1: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Interactor 2: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.895

Property	Details
Experiments	9581554, 17353931, 14651979, 15629149
Identification Methods	pull down, anti bait coimmunoprecipitation, coimmunoprecipitation, two hybrid
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0007165 - signal transduction GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1367 Hs			1 246
+	Hs
		435597 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		435604 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		435542 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		435594 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		435554 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62
+	Hs
		411315 INSR_HUMAN (32-1365): 0: 1219: 56.54		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Hs
		411316 INSR_HUMAN (32-1365): 0: 1219: 56.54		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62
+	Dm
		448232 INSR_DROME (12-1356): 0: 910: 32.97		1433Z_DROME (2-246): 4.79e-141: 396: 78.78
+	At
		965369 CLV1_ARATH (340-1268): 0: 585: 15.24		14332_ARATH (1-241): 4.75e-145: 407: 63.27
+	Hs
		384604 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		384357 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Hs
		169169 MUSK_HUMAN (993-1262): 8.25e-69: 251: 42.96		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		674348 UFO_HUMAN (790-1271): 9.27e-68: 249: 32.10		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Hs
		384623 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		674386 UFO_HUMAN (790-1271): 9.27e-68: 249: 32.10		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		384306 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		384598 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		384689 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Hs
		384358 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62
+	Hs
		169164 MUSK_HUMAN (993-1262): 8.25e-69: 251: 42.96		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62