HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	24189400, 22939624
Identification Methods	affinity chromatography technology, luminescence based mammalian interactome mapping, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0031625 - ubiquitin protein ligase binding GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 1342
+	Hs
		438189 HS90B_HUMAN (1-724): 0: 1086: 100.00		ERBB4_HUMAN (1-1162): 0: 1152: 50.94
+	Hs
		383544 HS90B_HUMAN (1-724): 0: 1086: 100.00		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		383537 HS90A_HUMAN (1-724): 0: 1072: 85.25		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		337799 HS90B_HUMAN (1-724): 0: 1086: 100.00		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		337788 HS90A_HUMAN (1-724): 0: 1072: 85.25		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		337314 HS90B_HUMAN (1-724): 0: 1086: 100.00		ABL1_HUMAN (696-1307): 5.97e-133: 439: 22.51
+	Hs
		69196 HS90B_HUMAN (1-724): 0: 1086: 100.00		A9UEZ6_HUMAN (696-1307): 3.93e-128: 435: 22.51
+	Hs
		337312 HS90A_HUMAN (1-724): 0: 1072: 85.25		ABL1_HUMAN (696-1307): 5.97e-133: 439: 22.51
+	Hs
		438028 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHB1_HUMAN (644-993): 1.32e-118: 396: 27.87
+	Hs
		431435 HS90A_HUMAN (1-724): 0: 1072: 85.25		RET_HUMAN (518-1072): 1.47e-118: 399: 21.15
+	Hs
		435497 HS90B_HUMAN (1-724): 0: 1086: 100.00		IGF1R_HUMAN (577-1061): 4.71e-104: 363: 21.00
+	Hs
		437918 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHA2_HUMAN (665-996): 4.18e-104: 356: 29.40
+	Hs
		438167 HS90B_HUMAN (1-724): 0: 1086: 100.00		FAK2_HUMAN (673-1201): 9.77e-104: 355: 25.96
+	Hs
		438029 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHA4_HUMAN (656-996): 2.83e-103: 354: 27.79
+	Hs
		431438 HS90A_HUMAN (1-724): 0: 1072: 85.25		IGF1R_HUMAN (577-1061): 4.71e-104: 363: 21.00
+	Hs
		438103 HS90B_HUMAN (1-724): 0: 1086: 100.00		ACK1_HUMAN (683-961): 1.22e-46: 184: 38.73
+	Gg
		94460 HS90B_CHICK (1-724): 0: 1098: 93.66		KSYK_CHICK (715-958): 2e-43: 170: 36.80
+	Hs
		437966 HS90B_HUMAN (1-724): 0: 1086: 100.00		ABL2_HUMAN (705-971): 7.69e-43: 173: 36.06
+	Hs
		438096 HS90B_HUMAN (1-724): 0: 1086: 100.00		FAK1_HUMAN (713-992): 4.43e-41: 167: 32.19
+	Hs
		437855 HS90B_HUMAN (1-724): 0: 1086: 100.00		INSRR_HUMAN (329-644): 4.31e-16: 86.4: 14.51