Protein: TREA
Cytosolic neutral trehalase (EC 3.2.1.28) (Alpha,alpha-trehalase) (Alpha,alpha-trehalose glucohydrolase)

Gene: TREA, NTH1
Organism: Saccharomyces cerevisiae S288C
Interactions: 54
UniProt ID: P32356

Gene Ontology (top 5):
GO:0004555 - alpha,alpha-trehalase activity
GO:0005509 - calcium ion binding
GO:0005737 - cytoplasm
GO:0005993 - trehalose catabolic process
GO:0015927 - trehalase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

709618

BMH1
Protein BMH1

13

2

Small-scale

0.984

High

735420

BMH2
Protein BMH2

8

2

Small-scale

0.976

High

441066

KAPA
cAMP-dependent protein kinase type 1

6

2

Small-scale

0.733

High

735421

TREB
Probable trehalase

1

1

High-throughput

0.665

High

735441

DCPS
m7GpppX diphosphatase

3

1

High-throughput

0.647

High

364405

CDK1
Cyclin-dependent kinase 1

3

0

Small-scale

0.641

High

579027

HSC82
ATP-dependent molecular chaperone HSC82

3

2

High-throughput

0.633

High

544139

SSB1
Ribosome-associated molecular chaperone SSB1

2

3

High-throughput

0.601

High

392400

HSP82
ATP-dependent molecular chaperone HSP82

2

2

High-throughput

0.584

High

441340

KAPB
cAMP-dependent protein kinase type 2

2

2

Small-scale

0.565

High

526158

HSP72
Heat shock protein SSA2

2

3

High-throughput

0.552

High

735430

SSB2
Ribosome-associated molecular chaperone SSB2

2

3

High-throughput

0.552

High

437893

KAPC
cAMP-dependent protein kinase type 3

1

2

Small-scale

0.501

High

692304

KCC1
Calcium/calmodulin-dependent protein kinase I

1

1

High-throughput

0.501

High

509446

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

735434

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

0

High-throughput

0.480

High

735449

SKS1
Serine/threonine-protein kinase SKS1

1

0

High-throughput

0.480

High

735419

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

1

High-throughput

0.479

High

735422

KAE1
tRNA N6-adenosine threonylcarbamoyltransferase

1

1

High-throughput

0.479

High

735437

APJ1
J domain-containing protein APJ1

1

1

High-throughput

0.479

High

735446

YRA1
RNA annealing protein YRA1

1

1

High-throughput

0.470

High

732022

MLF3
Protein MLF3

1

0

High-throughput

0.458

High

735424

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

735427

PIK1
Phosphatidylinositol 4-kinase PIK1

1

0

High-throughput

0.458

High

735429

YEY6
MYG1 protein YER156C

1

0

Small-scale

0.458

High

735436

PSP1
Protein PSP1

1

0

High-throughput

0.458

High

735438

FRK1
Fatty acyl-CoA synthetase and RNA processing-associated kinase 1

1

0

High-throughput

0.458

High

735440

VPS60
Vacuolar protein-sorting-associated protein 60

1

0

Small-scale

0.458

High

735445

RCN2
Regulator of calcineurin 2

1

0

High-throughput

0.458

High

735447

PUF2
mRNA-binding protein PUF2

1

0

High-throughput

0.458

High

735448

KCS1
Inositol hexakisphosphate kinase 1

1

0

High-throughput

0.458

High

523336

HSP71
Heat shock protein SSA1

1

3

High-throughput

0.445

High

592086

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.445

High

735431

6P21
6-phosphofructo-2-kinase 1

1

1

High-throughput

0.445

High

394342

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

403403

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

High-throughput

0.426

High

427179

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.426

High

444456

DED1
ATP-dependent RNA helicase DED1

1

0

High-throughput

0.426

High

486084

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.426

High

597067

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.426

High

735426

TCPB
T-complex protein 1 subunit beta

1

0

High-throughput

0.426

High

735435

RL4B
Large ribosomal subunit protein uL4B

1

0

High-throughput

0.426

High

735432

DJP1
DnaJ-like protein 1

1

1

High-throughput

0.407

High

448936

TOP2
DNA topoisomerase 2

1

0

High-throughput

0.279

Low

735444

YP216
Putative ISWI chromatin-remodeling complex subunit YPL216W

1

0

High-throughput

0.269

Low

679475

CDC48
Cell division control protein 48

1

0

High-throughput

0.249

Low

706471

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

735423

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

735425

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.249

Low

735428

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

735433

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

0

High-throughput

0.249

Low

735439

DIG2
Down-regulator of invasive growth 2

1

0

High-throughput

0.249

Low

735442

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.249

Low

735443

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025