HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: STIP1 (P31948)
Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521)
Gene: STIP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.972

Property	Details
Experiments	18285346, 28514442, 35271311, 33239621, 25036637, 36114006, 34349018, 37071682, 21170051
Identification Methods	pull down, affinity chromatography technology, cross-linking study, surface plasmon resonance, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	HSP90~TPR_8
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0032991 - protein-containing complex GO:0120293 - dynein axonemal particle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 543
+	Hs
		111934 K9JA46_HUMAN (1-724): 0: 1072: 85.25		STIP1_HUMAN (1-543): 2.75e-98: 309: 100.00
+	Hs
		431574 HS90A_HUMAN (1-724): 0: 1072: 85.25		STIP1_HUMAN (1-543): 2.75e-98: 309: 100.00
+	Dm
		365481 HSP83_DROME (10-724): 0: 1057: 78.46		Q9VPN5_DROME (1-542): 1.4e-79: 259: 47.42
+	At
		878278 HS902_ARATH (10-724): 0: 1003: 66.85		HSOP2_ARATH (3-543): 4.73e-97: 307: 41.86
+	Hs
		438464 HS90B_HUMAN (1-724): 0: 1086: 100.00		DNJC7_HUMAN (209-487): 3.28e-26: 113: 18.28
+	Hs
		432195 HS90A_HUMAN (1-724): 0: 1072: 85.25		DNJC7_HUMAN (209-487): 3.28e-26: 113: 18.28
+	Hs
		438533 HS90B_HUMAN (1-724): 0: 1086: 100.00		RPAP3_HUMAN (2-141): 4.46e-20: 96.1: 27.14
+	Hs
		174561 HS90B_HUMAN (1-724): 0: 1086: 100.00		OGT1_HUMAN (5-261): 5.16e-18: 90: 13.57
+	Hs
		432268 HS90A_HUMAN (1-724): 0: 1072: 85.25		RPAP3_HUMAN (2-141): 4.46e-20: 96.1: 27.14
+	Hs
		174556 HS90A_HUMAN (1-724): 0: 1072: 85.25		OGT1_HUMAN (5-261): 5.16e-18: 90: 13.57
+	Hs
		297025 HS90B_HUMAN (1-724): 0: 1086: 100.00		TOM70_HUMAN (207-543): 4.08e-13: 73.8: 11.00
+	Hs
		213454 HS90B_HUMAN (1-724): 0: 1086: 100.00		SGTA_HUMAN (202-327): 3.98e-09: 60.1: 32.54
+	Hs
		297024 HS90A_HUMAN (1-724): 0: 1072: 85.25		TOM70_HUMAN (207-543): 4.08e-13: 73.8: 11.00
+	Hs
		431774 HS90A_HUMAN (1-724): 0: 1072: 85.25		SPAG1_HUMAN (405-527): 2.93e-11: 68.4: 14.63
+	Hs
		431797 HS90A_HUMAN (1-724): 0: 1072: 85.25		IFT88_HUMAN (4-150): 8.37e-09: 60.3: 12.93
+	Hs
		213451 HS90A_HUMAN (1-724): 0: 1072: 85.25		SGTA_HUMAN (202-327): 3.98e-09: 60.1: 32.54
+	Ce
		183711 HSP90_CAEEL (8-724): 0: 976: 74.34		STIP1_CAEEL (2-280): 5.87e-13: 71.9: 13.24
+	Sc
		365568 HSP82_YEAST (12-724): 0: 927: 61.26		TOM70_YEAST (353-515): 2.09e-14: 78: 22.09
+	Ca
		804535 HSP90_CANAL (8-724): 0: 929: 60.42		Q5ADP3_CANAL (1-178): 1.05e-12: 73: 8.12
+	Sp
		784798 HSP90_SCHPO (10-724): 0: 929: 62.48		STI1_SCHPO (2-278): 8.15e-10: 63.4: 9.86