Protein: YPK1
Serine/threonine-protein kinase YPK1 (EC 2.7.11.1) (Sphingosine-like immunosuppressant resistant protein 2) (Yeast protein kinase 1)

Gene: YPK1
Organism: Saccharomyces cerevisiae S288C
Interactions: 107
UniProt ID: P12688

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005935 - cellular bud neck

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

554720

FPK1
Flippase kinase 1

4

16

Small-scale

0.899

High

554659

HSC82
ATP-dependent molecular chaperone HSC82

3

20

High-throughput

0.817

High

554730

PKH1
Serine/threonine-protein kinase PKH1

2

17

Small-scale

0.778

High

554679

TOR2
Serine/threonine-protein kinase TOR2

4

20

Small-scale

0.694

High

554664

DBF2
Cell cycle protein kinase DBF2

1

17

High-throughput

0.691

High

554676

DBF20
Serine/threonine-protein kinase DBF20

1

17

High-throughput

0.691

High

554661

YPK2
Serine/threonine-protein kinase YPK2/YKR2

1

16

High-throughput

0.665

High

554737

YSP2
Membrane-anchored lipid-binding protein YSP2

3

5

Small-scale

0.655

High

470092

SPS1
Sporulation-specific protein 1

1

18

High-throughput

0.647

High

554665

RAD53
Serine/threonine-protein kinase RAD53

1

15

High-throughput

0.647

High

554703

SLM1
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1

3

0

Small-scale

0.629

High

392116

HSP82
ATP-dependent molecular chaperone HSP82

1

20

High-throughput

0.618

High

522878

HSP71
Heat shock protein SSA1

3

13

High-throughput

0.611

High

554666

FPS1
Glycerol uptake/efflux facilitator protein

2

1

Small-scale

0.602

High

554718

ORM1
Protein ORM1

2

1

Small-scale

0.602

High

554735

ORM2
Protein ORM2

2

1

Small-scale

0.602

High

554675

HS104
Heat shock protein 104

2

2

High-throughput

0.584

High

517860

SSBP1
Single-stranded nucleic acid-binding protein

1

15

High-throughput

0.579

High

554711

JSN1
Protein JSN1

1

1

Small-scale

0.579

High

554744

PUF2
mRNA-binding protein PUF2

1

1

Small-scale

0.579

High

554723

GPD1
Glycerol-3-phosphate dehydrogenase [NAD(+)] 1

2

0

Small-scale

0.577

High

554726

ROD1
Protein ROD1

2

0

Small-scale

0.577

High

554727

MUK1
Protein MUK1

2

0

Small-scale

0.577

High

554670

MAS5
Mitochondrial protein import protein MAS5

1

6

High-throughput

0.575

High

554696

CAJ1
Protein CAJ1

1

9

High-throughput

0.575

High

510132

HSP77
Import motor subunit, mitochondrial

2

19

High-throughput

0.571

High

554671

RS5
Small ribosomal subunit protein uS7

1

3

Small-scale

0.561

High

543625

SSB1
Ribosome-associated molecular chaperone SSB1

2

13

High-throughput

0.552

High

554662

HSP60
Heat shock protein 60, mitochondrial

2

14

High-throughput

0.552

High

554701

SSB2
Ribosome-associated molecular chaperone SSB2

2

13

High-throughput

0.552

High

554691

IF5
Eukaryotic translation initiation factor 5

1

4

High-throughput

0.536

High

554700

TSC11
Target of rapamycin complex 2 subunit TSC11

1

8

High-throughput

0.536

High

554702

MOB1
DBF2 kinase activator protein MOB1

1

2

High-throughput

0.536

High

554738

AVO1
Target of rapamycin complex 2 subunit AVO1

1

2

High-throughput

0.536

High

554678

FIMB
Fimbrin

1

3

High-throughput

0.515

High

554715

INP52
Polyphosphatidylinositol phosphatase INP52

1

1

High-throughput

0.515

High

554708

JJJ2
J protein JJJ2

1

10

High-throughput

0.514

High

554732

GIS4
Protein GIS4

1

0

High-throughput

0.513

High

450508

FAS1
Fatty acid synthase subunit beta

1

2

High-throughput

0.501

High

554682

TOR1
Serine/threonine-protein kinase TOR1

1

20

Small-scale

0.501

High

554694

LAM4
Membrane-anchored lipid-binding protein LAM4

1

5

Small-scale

0.501

High

554713

CCH1
Calcium-channel protein CCH1

1

1

Small-scale

0.501

High

554699

RPN3
26S proteasome regulatory subunit RPN3

1

2

High-throughput

0.494

High

554674

XPO1
Exportin-1

1

7

High-throughput

0.489

High

554725

ACAC
Acetyl-CoA carboxylase

1

9

Small-scale

0.481

High

554728

ATG21
Autophagy-related protein 21

1

0

Small-scale

0.480

High

433401

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.479

High

434761

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

502800

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.479

High

503998

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.479

High

512213

RS6A
Small ribosomal subunit protein eS6A

1

6

High-throughput

0.479

High

518180

IF4A
ATP-dependent RNA helicase eIF4A

1

10

High-throughput

0.479

High

554663

DBP5
ATP-dependent RNA helicase DBP5

1

11

High-throughput

0.479

High

554669

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.479

High

554680

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

554681

RS3A1
Small ribosomal subunit protein eS1A

1

3

High-throughput

0.479

High

554687

GBLP
Small ribosomal subunit protein RACK1

1

14

Small-scale

0.479

High

554706

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

5

High-throughput

0.479

High

554714

UBC9
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.479

High

554721

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

1

High-throughput

0.479

High

554731

SIZ1
E3 SUMO-protein ligase SIZ1

1

4

High-throughput

0.479

High

554734

SYRC
Arginine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

554742

RIO1
Serine/threonine-protein kinase RIO1

1

2

High-throughput

0.479

High

554747

AHA1
Hsp90 co-chaperone AHA1

1

3

High-throughput

0.479

High

554660

TEC1
Ty transcription activator TEC1

1

1

High-throughput

0.470

High

554741

LEU9
2-isopropylmalate synthase 2, mitochondrial

1

2

High-throughput

0.470

High

554692

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

554697

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

554733

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.458

High

554740

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

554672

LAC1
Ceramide synthase LAC1

1

4

Small-scale

0.457

High

554688

SMP1
Transcription factor SMP1

1

3

Small-scale

0.457

High

554693

LAG1
Ceramide synthase LAG1

1

4

Small-scale

0.457

High

554695

YHP7
Uncharacterized protein YHR097C

1

1

Small-scale

0.457

High

554745

HER1
HMG2-induced ER-remodeling protein 1

1

1

Small-scale

0.457

High

554683

GCS1
ADP-ribosylation factor GTPase-activating protein GCS1

1

11

High-throughput

0.457

High

394167

EF1A
Elongation factor 1-alpha

1

5

High-throughput

0.445

High

453385

PYR1
Multifunctional protein URA2

1

4

High-throughput

0.445

High

525768

HSP72
Heat shock protein SSA2

1

13

High-throughput

0.445

High

554677

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

554690

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

7

High-throughput

0.445

High

554658

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

554673

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

554684

SPT10
Protein SPT10

1

1

High-throughput

0.437

High

554704

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.437

High

554710

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.437

High

554716

CDH1
APC/C activator protein CDH1

1

11

Small-scale

0.437

High

554722

H3
Histone H3

1

13

High-throughput

0.437

High

554724

NUM1
Nuclear migration protein NUM1

1

14

High-throughput

0.437

High

554729

ESP1
Separin

1

1

High-throughput

0.437

High

554743

SIZ2
E3 SUMO-protein ligase SIZ2

1

4

High-throughput

0.437

High

554748

CMR1
DNA damage-binding protein CMR1

1

5

High-throughput

0.437

High

554746

HSP42
Heat shock protein 42

1

2

High-throughput

0.407

High

554736

CORO
Coronin-like protein

1

0

High-throughput

0.269

Low

554668

GLRX1
Glutaredoxin-1

1

0

High-throughput

0.261

Low

554686

GPT2
Glycerol-3-phosphate O-acyltransferase 2

1

0

Small-scale

0.261

Low

554705

CDC1
Cell division control protein 1

1

0

Small-scale

0.261

Low

554709

DS1P1
Dihydrosphingosine 1-phosphate phosphatase LCB3

1

0

Small-scale

0.261

Low

554717

PEX31
Peroxisomal membrane protein PEX31

1

0

Small-scale

0.261

Low

554719

YN87
Uncharacterized protein YNR014W

1

0

Small-scale

0.261

Low

554685

SPT21
Protein SPT21

1

0

High-throughput

0.249

Low

554689

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

554698

ISC1
Inositol phosphosphingolipids phospholipase C

1

0

Small-scale

0.249

Low

554667

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.232

Low

554707

RRP41
Exosome complex component SKI6

1

0

High-throughput

0.232

Low

554712

MTR3
Exosome complex component MTR3

1

0

High-throughput

0.232

Low

554739

RRP40
Exosome complex component RRP40

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025