HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	27684187, 31501420
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 504
+	Hs
		125101 HS90B_HUMAN (1-724): 0: 1086: 100.00		WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54
+	Hs
		125097 HS90A_HUMAN (1-724): 0: 1072: 85.25		WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54
+	Hs
		438516 HS90B_HUMAN (1-724): 0: 1086: 100.00		WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42
+	Hs
		432252 HS90A_HUMAN (1-724): 0: 1072: 85.25		WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42
+	Hs
		431639 HS90A_HUMAN (1-724): 0: 1072: 85.25		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Hs
		538147 ENPL_HUMAN (3-693): 0: 917: 46.44		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Sc
		366333 HSP82_YEAST (12-724): 0: 927: 61.26		RSP5_YEAST (3-504): 1.79e-105: 334: 15.25
+	Sc
		543785 HSC82_YEAST (13-724): 0: 922: 60.22		RSP5_YEAST (3-504): 1.79e-105: 334: 15.25
+	Hs
		538146 ENPL_HUMAN (3-693): 0: 917: 46.44		NEDD4_HUMAN (40-504): 2.15e-103: 338: 19.26
+	Sc
		366793 HSP82_YEAST (12-724): 0: 927: 61.26		TOM1_YEAST (261-504): 2.18e-46: 176: 11.34
+	Sc
		544310 HSC82_YEAST (13-724): 0: 922: 60.22		TOM1_YEAST (261-504): 2.18e-46: 176: 11.34