Protein: DPYL1
Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Inactive dihydropyrimidinase) (Unc-33-like phosphoprotein 3) (ULIP-3)

Gene: DPYL1, CRMP1
Organism: Homo sapiens
Interactions: 133
UniProt ID: Q14194

Gene Ontology (top 5):
GO:0005813 - centrosome
GO:0005819 - spindle
GO:0005829 - cytosol
GO:0006139 - nucleobase-containing compound metabolic process
GO:0007399 - nervous system development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1123192

DPYL3
Dihydropyrimidinase-related protein 3

5

17

High-throughput

0.936

High

1123198

DPYL2
Dihydropyrimidinase-related protein 2

5

18

Small-scale

0.925

High

1123191

DPYL1
Dihydropyrimidinase-related protein 1

2

17

High-throughput

0.815

High

155850

DPYL4
Dihydropyrimidinase-related protein 4

2

18

High-throughput

0.776

High

124338

HAX1
HCLS1-associated protein X-1

3

5

High-throughput

0.667

High

1123199

DGUOK
Deoxyguanosine kinase, mitochondrial

3

4

High-throughput

0.667

High

1123200

BOREA
Borealin

3

2

High-throughput

0.667

High

1123233

KTU
Protein kintoun

3

5

High-throughput

0.667

High

1123234

ARMC1
Armadillo repeat-containing protein 1

3

3

High-throughput

0.667

High

1123245

RRP7A
Ribosomal RNA-processing protein 7 homolog A

3

2

High-throughput

0.667

High

843557

HD
Huntingtin

2

6

High-throughput

0.631

High

1123226

UBA5
Ubiquitin-like modifier-activating enzyme 5

2

2

High-throughput

0.628

High

474670

VIME
Vimentin

2

2

High-throughput

0.627

High

1123242

AP3M1
AP-3 complex subunit mu-1

3

2

High-throughput

0.616

High

1123239

NUFP1
FMR1-interacting protein NUFIP1

3

4

High-throughput

0.609

High

992744

RACK1
Small ribosomal subunit protein RACK1

2

5

High-throughput

0.606

High

1123206

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

2

0

High-throughput

0.602

High

934599

TERA
Transitional endoplasmic reticulum ATPase

2

10

High-throughput

0.594

High

405457

KITH
Thymidine kinase, cytosolic

2

0

High-throughput

0.594

High

181109

AXIN1
Axin-1

1

1

High-throughput

0.568

High

898462

PPT1
Palmitoyl-protein thioesterase 1

2

0

Small-scale

0.559

High

622163

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

1

High-throughput

0.541

High

675027

TNR6
Tumor necrosis factor receptor superfamily member 6

1

2

High-throughput

0.541

High

729267

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

1

High-throughput

0.541

High

899899

FXR1
RNA-binding protein FXR1

1

4

High-throughput

0.541

High

1123212

TFG
Protein TFG

1

8

High-throughput

0.541

High

1123214

EXOS8
Exosome complex component RRP43

1

3

High-throughput

0.541

High

1123217

CK5P2
CDK5 regulatory subunit-associated protein 2

1

4

High-throughput

0.541

High

1123218

TCPH
T-complex protein 1 subunit eta

1

2

High-throughput

0.541

High

1123223

BTBD2
BTB/POZ domain-containing protein 2

1

2

High-throughput

0.541

High

1123241

KLH20
Kelch-like protein 20

1

1

High-throughput

0.541

High

1123244

PHOCN
MOB-like protein phocein

1

1

High-throughput

0.541

High

256467

TOM1
Target of Myb1 membrane trafficking protein

1

2

High-throughput

0.536

High

1123207

TTLL6
Tubulin polyglutamylase TTLL6

1

1

High-throughput

0.536

High

1123209

ARI1B
AT-rich interactive domain-containing protein 1B

1

2

High-throughput

0.536

High

1123224

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

8

High-throughput

0.536

High

127956

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

0

High-throughput

0.518

High

182049

RGL2
Ral guanine nucleotide dissociation stimulator-like 2

1

0

High-throughput

0.518

High

391614

FRIH
Ferritin heavy chain

1

0

High-throughput

0.518

High

459589

PROF1
Profilin-1

1

0

High-throughput

0.518

High

627650

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

0

High-throughput

0.518

High

639605

SAT1
Diamine acetyltransferase 1

1

0

High-throughput

0.518

High

714854

EF1D
Elongation factor 1-delta

1

0

High-throughput

0.518

High

895486

SPB9
Serpin B9

1

0

High-throughput

0.518

High

974128

RUXG
Small nuclear ribonucleoprotein G

1

0

High-throughput

0.518

High

1123194

PA1B3
Platelet-activating factor acetylhydrolase IB subunit alpha1

1

0

High-throughput

0.518

High

1123203

PMF1
Polyamine-modulated factor 1

1

0

High-throughput

0.518

High

1123211

RSPH1
Radial spoke head 1 homolog

1

0

High-throughput

0.518

High

1123216

CK5P3
CDK5 regulatory subunit-associated protein 3

1

0

High-throughput

0.518

High

1123220

LRRC1
Leucine-rich repeat-containing protein 1

1

0

High-throughput

0.518

High

1123222

CC106
Coiled-coil domain-containing protein 106

1

0

High-throughput

0.518

High

1123229

RTN4
Reticulon-4

1

0

High-throughput

0.518

High

1123243

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

0

High-throughput

0.518

High

1123246

EPN1
Epsin-1

1

0

High-throughput

0.518

High

987354

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

1

High-throughput

0.515

High

1123195

CNN3
Calponin-3

1

1

High-throughput

0.515

High

384669

CRYAB
Alpha-crystallin B chain

1

1

High-throughput

0.515

High

461470

HS90A
Heat shock protein HSP 90-alpha

1

2

High-throughput

0.515

High

1109549

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

1

0

High-throughput

0.513

High

221126

SPY2
Protein sprouty homolog 2

1

1

High-throughput

0.508

High

557300

SRC
Proto-oncogene tyrosine-protein kinase Src

1

3

High-throughput

0.508

High

833412

RGS2
Regulator of G-protein signaling 2

1

1

High-throughput

0.508

High

884330

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

1

High-throughput

0.508

High

1123197

T22D1
TSC22 domain family protein 1

1

4

High-throughput

0.508

High

1123240

AMFR
E3 ubiquitin-protein ligase AMFR

1

5

High-throughput

0.508

High

169551

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

2

Small-scale

0.501

High

1123202

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

Small-scale

0.501

High

1123231

DISC1
Disrupted in schizophrenia 1 protein

1

2

Small-scale

0.501

High

188489

NVL
Nuclear valosin-containing protein-like

1

10

High-throughput

0.494

High

353324

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.494

High

423906

ALDH2
Aldehyde dehydrogenase, mitochondrial

1

3

High-throughput

0.494

High

481280

HMGB1
High mobility group protein B1

1

4

High-throughput

0.494

High

588677

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.494

High

600299

ZNF24
Zinc finger protein 24

1

1

High-throughput

0.494

High

729053

HNRH3
Heterogeneous nuclear ribonucleoprotein H3

1

1

High-throughput

0.494

High

990964

UBE2B
Ubiquitin-conjugating enzyme E2 B

1

1

High-throughput

0.494

High

1063243

GOGA2
Golgin subfamily A member 2

1

1

High-throughput

0.494

High

1091765

PP1R8
Nuclear inhibitor of protein phosphatase 1

1

1

High-throughput

0.494

High

1123196

PCH2
Pachytene checkpoint protein 2 homolog

1

11

High-throughput

0.494

High

1123213

FUBP1
Far upstream element-binding protein 1

1

1

High-throughput

0.494

High

1123221

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

1

High-throughput

0.494

High

1123235

ARL15
ADP-ribosylation factor-like protein 15

1

1

High-throughput

0.494

High

408867

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.493

High

660263

BDNF
Neurotrophic factor BDNF precursor form

1

0

High-throughput

0.493

High

667301

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

2

High-throughput

0.489

High

906883

GPM6A
Neuronal membrane glycoprotein M6-a

1

4

High-throughput

0.489

High

1123210

XAGE3
X antigen family member 3

1

2

High-throughput

0.489

High

939621

BID
BH3-interacting domain death agonist

1

0

High-throughput

0.486

High

1123237

M3K20
Mitogen-activated protein kinase kinase kinase 20

1

0

High-throughput

0.486

High

411917

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.479

High

457435

TBB5
Tubulin beta chain

1

7

High-throughput

0.479

High

541483

FGFR1
Fibroblast growth factor receptor 1

1

9

High-throughput

0.479

High

651323

CBL
E3 ubiquitin-protein ligase CBL

1

5

High-throughput

0.479

High

904702

MECP2
Methyl-CpG-binding protein 2

1

4

High-throughput

0.479

High

986420

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

1026374

HSF1
Heat shock factor protein 1

1

2

High-throughput

0.479

High

1047412

K1C17
Keratin, type I cytoskeletal 17

1

2

High-throughput

0.479

High

1123205

TBA1A
Tubulin alpha-1A chain

1

13

High-throughput

0.479

High

1123208

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

1123215

SPDLY
Protein Spindly

1

4

High-throughput

0.479

High

1123201

GGEE3
Putative G antigen family E member 3

1

1

High-throughput

0.470

High

287695

KS6A5
Ribosomal protein S6 kinase alpha-5

1

3

High-throughput

0.464

High

1095024

DUS4
Dual specificity protein phosphatase 4

1

2

High-throughput

0.464

High

1123238

DJB11
DnaJ homolog subfamily B member 11

1

1

High-throughput

0.464

High

613352

VINC
Vinculin

1

0

High-throughput

0.458

High

245698

GANP
Germinal-center associated nuclear protein

1

3

High-throughput

0.457

High

1056719

FMR1
Fragile X messenger ribonucleoprotein 1

1

4

High-throughput

0.457

High

255018

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

1

High-throughput

0.445

High

529784

TAU
Microtubule-associated protein tau

1

10

High-throughput

0.445

High

1123227

RGAP1
Rac GTPase-activating protein 1

1

3

High-throughput

0.445

High

139706

CAC1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A

1

3

High-throughput

0.439

High

105922

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

463961

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

9

High-throughput

0.437

High

1123193

RBM39
RNA-binding protein 39

1

1

High-throughput

0.437

High

1123204

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.437

High

1123228

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.437

High

213129

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.426

High

1123225

PITH1
PITH domain-containing protein 1

2

0

High-throughput

0.328

High

183644

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.282

High

892291

SPS1
Selenide, water dikinase 1

1

0

High-throughput

0.282

High

938531

CCL18
C-C motif chemokine 18

1

0

High-throughput

0.282

High

962951

CH10
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.282

High

1123219

NAT9
Alpha/beta-tubulin-N-acetyltransferase 9

1

0

High-throughput

0.282

High

627971

ANXA7
Annexin A7

1

0

High-throughput

0.265

Low

1103688

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

0

High-throughput

0.265

Low

1123230

YAE1
Protein YAE1 homolog

1

0

High-throughput

0.265

Low

377572

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

1031368

IFM3
Interferon-induced transmembrane protein 3

1

0

High-throughput

0.249

Low

344440

IL33
Interleukin-33

1

0

High-throughput

0.238

Low

572746

PA2GA
Phospholipase A2, membrane associated

1

0

High-throughput

0.238

Low

1123232

DDX18
ATP-dependent RNA helicase DDX18

1

0

High-throughput

0.238

Low

1123236

NSMA2
Sphingomyelin phosphodiesterase 3

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025