HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: GBRL2 (P60520)
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (General protein transport factor p16) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) (MAP1 light chain 3-related protein)
Gene: GABARAPL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.641

Property	Details
Experiments	22120110, 29149599, 20562859
Identification Methods	pull down, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:1901799 - negative regulation of proteasomal protein catabolic process
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 117
+	Hs
		305908 HS90B_HUMAN (1-724): 0: 1086: 100.00		GBRAP_HUMAN (1-117): 7.55e-57: 173: 57.27
+	Rn
		709236 HS90B_RAT (1-724): 0: 1089: 99.59		GBRL1_RAT (1-116): 7.89e-56: 170: 61.21
+	Hs
		438517 HS90B_HUMAN (1-724): 0: 1086: 100.00		GBRL1_HUMAN (1-116): 7.89e-56: 170: 61.21
+	Hs
		431708 HS90A_HUMAN (1-724): 0: 1072: 85.25		GBRL2_HUMAN (1-117): 1.08e-58: 178: 100.00
+	Hs
		305906 HS90A_HUMAN (1-724): 0: 1072: 85.25		GBRAP_HUMAN (1-117): 7.55e-57: 173: 57.27
+	Hs
		432253 HS90A_HUMAN (1-724): 0: 1072: 85.25		GBRL1_HUMAN (1-116): 7.89e-56: 170: 61.21
+	Rn
		948935 HS90A_RAT (1-724): 0: 1070: 84.45		GBRL1_RAT (1-116): 7.89e-56: 170: 61.21
+	Hs
		438528 HS90B_HUMAN (1-724): 0: 1086: 100.00		MLP3A_HUMAN (5-117): 2.01e-45: 144: 41.74
+	Hs
		438507 HS90B_HUMAN (1-724): 0: 1086: 100.00		MLP3B_HUMAN (2-117): 6.34e-44: 141: 38.14
+	Hs
		432262 HS90A_HUMAN (1-724): 0: 1072: 85.25		MLP3A_HUMAN (5-117): 2.01e-45: 144: 41.74
+	Hs
		432242 HS90A_HUMAN (1-724): 0: 1072: 85.25		MLP3B_HUMAN (2-117): 6.34e-44: 141: 38.14
+	Hs
		538179 ENPL_HUMAN (3-693): 0: 917: 46.44		GBRL2_HUMAN (1-117): 1.08e-58: 178: 100.00
+	Hs
		305943 ENPL_HUMAN (3-693): 0: 917: 46.44		GBRAP_HUMAN (1-117): 7.55e-57: 173: 57.27
+	Hs
		538395 ENPL_HUMAN (3-693): 0: 917: 46.44		GBRL1_HUMAN (1-116): 7.89e-56: 170: 61.21