Protein: CO1A2
Collagen alpha-2(I) chain (Alpha-2 type I collagen)

Gene: CO1A2, COL1A2
Organism: Homo sapiens
Interactions: 79
UniProt ID: P08123

Gene Ontology (top 5):
GO:0001501 - skeletal system development
GO:0001568 - blood vessel development
GO:0002020 - protease binding
GO:0005201 - extracellular matrix structural constituent
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

384088

CO1A1
Collagen alpha-1(I) chain

3

17

Small-scale

0.839

High

226674

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

4

4

High-throughput

0.644

High

465985

UBQL1
Ubiquilin-1

4

3

High-throughput

0.644

High

384277

CO3A1

1

16

High-throughput

0.618

High

288888

ERAL1
GTPase Era, mitochondrial

3

2

High-throughput

0.609

High

465970

CMKMT
Calmodulin-lysine N-methyltransferase

3

1

High-throughput

0.609

High

465984

UBQL2
Ubiquilin-2

3

3

High-throughput

0.596

High

465937

CO5A1

1

13

Small-scale

0.590

High

221507

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

2

2

High-throughput

0.574

High

465962

MESD
LRP chaperone MESD

2

2

High-throughput

0.553

High

376369

PDGFB
Platelet-derived growth factor subunit B

1

11

Small-scale

0.536

High

465955

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.536

High

465956

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

High-throughput

0.536

High

465945

SPB5
Serpin B5

1

2

Small-scale

0.527

High

465936

RAB5A
Ras-related protein Rab-5A

1

0

High-throughput

0.513

High

465938

COMT
Catechol O-methyltransferase

1

0

High-throughput

0.513

High

399260

MMP1
Interstitial collagenase

1

20

Small-scale

0.501

High

403057

PDGFA
Platelet-derived growth factor subunit A

1

11

Small-scale

0.501

High

465926

MMP2
72 kDa type IV collagenase

1

20

Small-scale

0.501

High

465927

MMP3
Stromelysin-1

1

20

Small-scale

0.501

High

465931

MMP9
Matrix metalloproteinase-9

1

20

Small-scale

0.501

High

465935

ITA2
Integrin alpha-2

1

9

Small-scale

0.501

High

465939

MMP8
Neutrophil collagenase

1

20

Small-scale

0.501

High

465951

MMP14
Matrix metalloproteinase-14

1

20

Small-scale

0.501

High

465953

MMP15
Matrix metalloproteinase-15

1

20

Small-scale

0.501

High

465954

MMP16
Matrix metalloproteinase-16

1

20

Small-scale

0.501

High

465959

DDR1
Epithelial discoidin domain-containing receptor 1

1

7

Small-scale

0.501

High

465976

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

4

High-throughput

0.494

High

465940

PAX3
Paired box protein Pax-3

1

3

High-throughput

0.489

High

465952

R144A
E3 ubiquitin-protein ligase RNF144A

1

1

High-throughput

0.489

High

465957

FANCC
Fanconi anemia group C protein

1

1

High-throughput

0.489

High

465958

CDK18
Cyclin-dependent kinase 18

1

1

High-throughput

0.489

High

465964

TMM44
Transmembrane protein 44

1

1

High-throughput

0.489

High

465971

YAF2
YY1-associated factor 2

1

1

High-throughput

0.489

High

465973

CBLL2
E3 ubiquitin-protein ligase CBLL2

1

2

High-throughput

0.489

High

407779

SHBG
Sex hormone-binding globulin

1

3

Small-scale

0.481

High

465978

MYOC
Myocilin

1

1

Small-scale

0.481

High

465947

CATK
Cathepsin K

1

0

Small-scale

0.480

High

362620

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

465929

GLU2B
Glucosidase 2 subunit beta

1

1

High-throughput

0.479

High

465933

TIMP2
Metalloproteinase inhibitor 2

1

7

High-throughput

0.479

High

465944

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

1

High-throughput

0.479

High

465960

FOXO1
Forkhead box protein O1

1

1

High-throughput

0.479

High

465961

CUL3
Cullin-3

1

13

High-throughput

0.479

High

465980

CHM4B
Charged multivesicular body protein 4b

1

3

High-throughput

0.479

High

158397

RFXK
DNA-binding protein RFXANK

1

3

Small-scale

0.470

High

465932

HIS3
Histatin-3

1

0

Small-scale

0.458

High

465965

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

0

High-throughput

0.458

High

431495

AP2A
Transcription factor AP-2-alpha

1

4

High-throughput

0.457

High

465941

LYOX
Protein-lysine 6-oxidase

1

2

Small-scale

0.457

High

465966

KLH22
Kelch-like protein 22

1

19

High-throughput

0.445

High

465968

LAIR2
Leukocyte-associated immunoglobulin-like receptor 2

1

15

High-throughput

0.445

High

105150

APRIO
Alternative prion protein

1

7

High-throughput

0.437

High

370960

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

465928

IRF1
Interferon regulatory factor 1

1

1

Small-scale

0.437

High

465930

IRF2
Interferon regulatory factor 2

1

1

Small-scale

0.437

High

465972

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.437

High

465979

NTPCR
Cancer-related nucleoside-triphosphatase

1

1

High-throughput

0.437

High

465981

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.437

High

160796

TOR1B
Torsin-1B

1

0

High-throughput

0.426

High

465946

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.426

High

465963

EXT1
Exostosin-1

1

0

High-throughput

0.426

High

465934

ZNF16
Zinc finger protein 16

1

1

Small-scale

0.417

High

465974

AP2C
Transcription factor AP-2 gamma

1

4

High-throughput

0.417

High

465982

DISC1
Disrupted in schizophrenia 1 protein

1

3

High-throughput

0.417

High

465943

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.407

High

465969

KCIP4
Kv channel-interacting protein 4

3

0

High-throughput

0.348

High

331697

MTMR5
Myotubularin-related protein 5

2

0

High-throughput

0.318

High

131296

EIF3F
Eukaryotic translation initiation factor 3 subunit F

2

0

High-throughput

0.316

High

465977

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

2

0

High-throughput

0.316

High

329888

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

0

High-throughput

0.279

Low

465983

CARF
CDKN2A-interacting protein

1

0

High-throughput

0.279

Low

465949

RFX5
DNA-binding protein RFX5

1

0

Small-scale

0.269

Low

465975

HDAC2
Histone deacetylase 2

1

0

Small-scale

0.269

Low

465950

DNLI4
DNA ligase 4

1

0

High-throughput

0.251

Low

465948

GATA4
Transcription factor GATA-4

1

0

Small-scale

0.249

Low

465967

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.249

Low

465942

IL2RG
Cytokine receptor common subunit gamma

1

0

High-throughput

0.232

Low

465986

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025