Protein: P5CR3
Pyrroline-5-carboxylate reductase 3 (P5C reductase 3) (P5CR 3) (EC 1.5.1.2) (Pyrroline-5-carboxylate reductase-like protein)

Gene: P5CR3, PYCR3
Organism: Homo sapiens
Interactions: 102
UniProt ID: Q53H96

Gene Ontology (top 5):
GO:0004735 - pyrroline-5-carboxylate reductase activity
GO:0005829 - cytosol
GO:0045171 - intercellular bridge
GO:0055129 - L-proline biosynthetic process
GO:0072686 - mitotic spindle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

687224

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

3

14

High-throughput

0.861

High

1121421

P5CR2
Pyrroline-5-carboxylate reductase 2

3

14

High-throughput

0.861

High

1121399

P5CR3
Pyrroline-5-carboxylate reductase 3

1

14

High-throughput

0.698

High

132886

SDCB1
Syntenin-1

3

1

High-throughput

0.675

High

790937

CDN2B
Cyclin-dependent kinase 4 inhibitor B

3

1

Small-scale

0.653

High

603180

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

3

0

High-throughput

0.638

High

636349

DNJB1
DnaJ homolog subfamily B member 1

2

2

High-throughput

0.611

High

314061

BAG4
BAG family molecular chaperone regulator 4

2

1

High-throughput

0.606

High

594548

PSB1
Proteasome subunit beta type-1

2

0

High-throughput

0.580

High

1121424

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

1121414

MTMRE
Myotubularin-related protein 14

2

0

High-throughput

0.559

High

843712

FXR1
RNA-binding protein FXR1

1

4

High-throughput

0.541

High

844093

FXR2
RNA-binding protein FXR2

1

4

High-throughput

0.541

High

259945

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

1

1

High-throughput

0.536

High

868529

ATX1
Ataxin-1

1

2

High-throughput

0.536

High

1041717

CUL3
Cullin-3

1

2

High-throughput

0.536

High

1052074

MAP7
Ensconsin

1

3

High-throughput

0.536

High

1068141

PDK2
[Pyruvate dehydrogenase

1

4

High-throughput

0.536

High

1074104

CYH1
Cytohesin-1

1

1

High-throughput

0.536

High

1081059

CCDC6
Coiled-coil domain-containing protein 6

1

2

High-throughput

0.536

High

1121406

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.536

High

1121418

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

1

High-throughput

0.536

High

1121428

CYH2
Cytohesin-2

1

1

High-throughput

0.536

High

1121439

DNJB4
DnaJ homolog subfamily B member 4

1

2

High-throughput

0.536

High

346962

MYC
Myc proto-oncogene protein

2

3

Small-scale

0.533

High

919414

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.513

High

1121410

ZN687
Zinc finger protein 687

1

0

High-throughput

0.513

High

1121412

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

1

0

High-throughput

0.513

High

1121431

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

1

0

High-throughput

0.513

High

1121435

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.513

High

1067974

PDK1
[Pyruvate dehydrogenase

1

4

High-throughput

0.489

High

1121402

KLD10
Kelch domain-containing protein 10

1

1

High-throughput

0.489

High

1121422

KCD12
BTB/POZ domain-containing protein KCTD12

1

1

High-throughput

0.489

High

1121430

AASD1
Alanyl-tRNA editing protein Aarsd1

1

2

High-throughput

0.489

High

1121442

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

1

High-throughput

0.489

High

1121445

TRI33
E3 ubiquitin-protein ligase TRIM33

1

2

High-throughput

0.489

High

681884

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

Small-scale

0.480

High

227651

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

475864

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

Small-scale

0.479

High

882344

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

2

High-throughput

0.479

High

903278

WDR5
WD repeat-containing protein 5

1

5

High-throughput

0.479

High

1121417

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

1121419

FBXW7
F-box/WD repeat-containing protein 7

1

4

High-throughput

0.479

High

1121429

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

1121438

BABA1
BRISC and BRCA1-A complex member 1

1

1

High-throughput

0.479

High

1121444

FZR1
Fizzy-related protein homolog

1

6

High-throughput

0.479

High

1121440

KCNG1
Potassium voltage-gated channel subfamily G member 1

1

1

High-throughput

0.470

High

1121425

ANM6
Protein arginine N-methyltransferase 6

1

1

High-throughput

0.464

High

298564

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

737842

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

0

High-throughput

0.458

High

841220

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.458

High

908653

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

1038434

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.458

High

1121415

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.458

High

1121416

DGCR8
Microprocessor complex subunit DGCR8

1

0

High-throughput

0.458

High

1121436

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1121407

ULK2
Serine/threonine-protein kinase ULK2

1

1

High-throughput

0.445

High

165857

KDM6B
Lysine-specific demethylase 6B

1

3

Small-scale

0.437

High

294905

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.437

High

379473

MYCN
N-myc proto-oncogene protein

1

3

High-throughput

0.437

High

726869

FUS
RNA-binding protein FUS

1

1

High-throughput

0.437

High

824081

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

1043847

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

2

High-throughput

0.437

High

1049060

TRI14
Tripartite motif-containing protein 14

1

2

High-throughput

0.437

High

1121401

TENS2
Tensin-2

1

1

High-throughput

0.437

High

1121403

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

1121405

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

1121420

PF21A
PHD finger protein 21A

1

2

High-throughput

0.437

High

1121426

UIMC1
BRCA1-A complex subunit RAP80

1

1

High-throughput

0.437

High

1121434

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

386857

P53
Cellular tumor antigen p53

1

0

Small-scale

0.426

High

829877

HXA1
Homeobox protein Hox-A1

1

0

High-throughput

0.282

High

382601

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

0

High-throughput

0.279

Low

571147

EGLN
Endoglin

1

0

High-throughput

0.279

Low

722610

T2FA
General transcription factor IIF subunit 1

1

0

High-throughput

0.279

Low

819063

AL3B2
Aldehyde dehydrogenase family 3 member B2

1

0

High-throughput

0.279

Low

885689

NXPH1
Neurexophilin-1

1

0

High-throughput

0.279

Low

1028482

KLRD1
Natural killer cells antigen CD94

1

0

High-throughput

0.279

Low

1108755

INAVA
Innate immunity activator protein

1

0

High-throughput

0.279

Low

1121400

KLH26
Kelch-like protein 26

1

0

High-throughput

0.279

Low

1121404

SPT6H
Transcription elongation factor SPT6

1

0

High-throughput

0.279

Low

1121408

MICU2
Calcium uptake protein 2, mitochondrial

1

0

High-throughput

0.279

Low

1121409

PUSL1
tRNA pseudouridine synthase-like 1

1

0

High-throughput

0.279

Low

1121411

ZCHC9
Zinc finger CCHC domain-containing protein 9

1

0

High-throughput

0.279

Low

1121423

HVCN1
Voltage-gated hydrogen channel 1

1

0

High-throughput

0.279

Low

1121427

GPX7
Glutathione peroxidase 7

1

0

High-throughput

0.279

Low

1121432

LACRT
Extracellular glycoprotein lacritin

1

0

High-throughput

0.279

Low

1121443

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.279

Low

1121446

RT18C
Small ribosomal subunit protein bS18m

1

0

High-throughput

0.279

Low

576274

LBP
Lipopolysaccharide-binding protein

1

0

High-throughput

0.251

Low

232207

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.249

Low

303288

HEXI1
Protein HEXIM1

1

0

High-throughput

0.249

Low

352125

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

1108691

ANR55
Ankyrin repeat domain-containing protein 55

1

0

High-throughput

0.249

Low

1121413

RN149
E3 ubiquitin-protein ligase RNF149

1

0

High-throughput

0.249

Low

1121433

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

1121441

RCOR1
REST corepressor 1

1

0

High-throughput

0.249

Low

1121447

SNX11
Sorting nexin-11

1

0

High-throughput

0.249

Low

230629

KATIP
Katanin-interacting protein

1

0

High-throughput

0.232

Low

563786

ZNF3
Zinc finger protein 3

1

0

High-throughput

0.232

Low

1121437

TB22B
TBC1 domain family member 22B

1

0

Small-scale

0.232

Low


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Last updated: 15 Jul 2024