HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: CDK6 (Q00534)
Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE)
Gene: CDK6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.802

Property	Details
Experiments	33961781, 22939624
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:0051726 - regulation of cell cycle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 326
+	Hs
		437908 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK2_HUMAN (10-311): 3.22e-146: 415: 47.39
+	Hs
		431549 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK2_HUMAN (10-311): 3.22e-146: 415: 47.39
+	Hs
		431742 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK6_HUMAN (1-326): 2.14e-145: 414: 100.00
+	Hs
		438075 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK3_HUMAN (10-314): 9.89e-138: 394: 45.63
+	Hs
		431741 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK3_HUMAN (10-314): 9.89e-138: 394: 45.63
+	Hs
		437843 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK4_HUMAN (9-304): 4e-126: 364: 70.23
+	Mm
		432408 HS90A_MOUSE (1-724): 0: 1068: 84.31		CDK4_MOUSE (9-305): 4.78e-132: 379: 68.67
+	Hs
		414683 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK1_HUMAN (10-305): 5.07e-129: 371: 45.18
+	Hs
		431476 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK4_HUMAN (9-304): 4e-126: 364: 70.23
+	Hs
		438077 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK5_HUMAN (11-303): 8.16e-115: 335: 45.64
+	Hs
		431743 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK5_HUMAN (11-303): 8.16e-115: 335: 45.64
+	At
		850796 HS903_ARATH (10-724): 0: 1002: 66.57		KSG7_ARATH (3-322): 1.62e-126: 368: 31.61
+	At
		850798 HS903_ARATH (10-724): 0: 1002: 66.57		MPK10_ARATH (7-326): 2.03e-125: 366: 34.15
+	At
		646589 HS901_ARATH (10-724): 0: 999: 67.97		KSG7_ARATH (3-322): 1.62e-126: 368: 31.61
+	Hs
		538107 ENPL_HUMAN (3-693): 0: 917: 46.44		CDK2_HUMAN (10-311): 3.22e-146: 415: 47.39
+	Ca
		793050 HSP90_CANAL (8-724): 0: 929: 60.42		CDK1_CANAL (10-300): 7.92e-127: 367: 46.28
+	Sc
		339312 HSP82_YEAST (12-724): 0: 927: 61.26		CDK1_YEAST (13-302): 1.33e-116: 340: 45.46
+	Sp
		383458 HSP90_SCHPO (10-724): 0: 929: 62.48		CDK1_SCHPO (11-304): 1.04e-115: 337: 44.37
+	Sc
		339406 HSC82_YEAST (13-724): 0: 922: 60.22		CDK1_YEAST (13-302): 1.33e-116: 340: 45.46
+	Hs
		515452 H90B3_HUMAN (1-724): 0: 815: 75.83		CDK4_HUMAN (9-304): 4e-126: 364: 70.23